Peptide Mediated Chiral Inorganic Nanomaterials for Combating Gram‐Negative Bacteria

Wang, Weiwei; Hao, Changlong; Sun, Maozhong; Xu, Liguang; Wu, Xiaoling; Xu, Chuanlai

doi:10.1002/adfm.201805112

Cited by 32 publications

(25 citation statements)

References 38 publications

(16 reference statements)

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“…PtCo@G@CPB on the H. pylori could catalyze ROS generation, leading to high local ROS concentration around the bacterial membrane. The ROS on the surface of H. pylori cell wall could directly disrupt the bacterial membranes and cause cytoplasmic leakage, eventually resulting in bacterial death 43 , 44 . The functionalization of CPB molecule on the surface of PtCo@G was characterized by fluorescence and Raman spectroscopy (Fig.…”

Section: Resultsmentioning

confidence: 99%

In vivo activation of pH-responsive oxidase-like graphitic nanozymes for selective killing of Helicobacter pylori

et al. 2021

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Helicobacter pylori infection is a major etiological factor in gastric diseases. However, clinical antibiotic therapy for H. pylori is limited by continuously decreased therapeutic efficacy and side effects to symbiotic bacteria. Herein, we develop an in vivo activatable pH-responsive graphitic nanozyme, PtCo@Graphene (PtCo@G), for selective treatment of H. pylori. Such nanozymes can resist gastric acid corrosion, exhibit oxidase-like activity to stably generate reactive oxygen species only in acidic gastric milieu and demonstrate superior selective bactericidal property. C18-PEGn-Benzeneboronic acid molecules are modified on PtCo@G, improving its targeting capability. Under acidic gastric pH, graphitic nanozymes show notable bactericidal activity toward H. pylori, while no bacterial killing is observed under intestinal conditions. In mouse model, high antibacterial capability toward H. pylori and negligible side effects toward normal tissues and symbiotic bacteria are achieved. Graphitic nanozyme displays the desired enzyme-like activities at corresponding physiological sites and may address critical issues in clinical treatment of H. pylori infections.

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Section: Resultsmentioning

confidence: 99%

In vivo activation of pH-responsive oxidase-like graphitic nanozymes for selective killing of Helicobacter pylori

et al. 2021

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“…PtCo@G@CPB on the H. pylori could catalyze ROS generation, leading to high local ROS concentration around the bacterial membrane. The ROS on the surface of H. pylori cell wall could directly disrupt the bacterial membranes and cause cytoplasmic leakage, eventually resulting in bacterial death 41,42 . The functionalization of CPB molecule on the surface of PtCo@G was characterized by uorescence and Raman spectroscopy ( Fig.…”

Section: Resultsmentioning

confidence: 99%

In vivo activation of pH-responsive oxidase-like graphitic-nanozymes for selective killing of Helicobacter pylori

Zhang

Deng

et al. 2020

Preprint

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Helicobacter pylori infection is a major etiological factor in various gastric diseases. However, clinical antibiotic triple therapy for H. pylori often encounters such critical problems as continuously decreased therapeutic efficacy and symbiotic bacteria experiencing severe side effects. Herein, we developed an in vivo activatable pH-responsive graphitic nanozyme, PtCo@Graphene (PtCo@G), for the selective treatment of H. pylori infections. Such nanozymes can resist gastric acid corrosion and activate oxidase-like activity to stably generate reactive oxygen species only in the acidic gastric milieu which endows them with superior selective bactericidal property. C18-PEGn-Benzeneboronic acid molecules were further modified on the PtCo@G, improving its targeting capability to H. pylori. Under acidic gastric pH, graphitic nanozymes showed notable bactericidal activity toward H. pylori, while no bacterial killing was observed under the intestinal condition. In the H. pylori-infected mouse model, high antibacterial capability toward H. pylori and negligible side effects toward normal tissues and symbiotic bacteria were also achieved. This graphitic nanozyme performs the desired enzyme-like activity at corresponding physiological sites and may address critical issues in the clinical treatment of H. pylori infections.

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“…Up to date, both inorganic and organic nanomaterials have been exploited for PDT. The inorganic nanomaterials display superior colloidal stability in the physiological milieu [ [65] , [66] , [67] , [68] , [69] , [70] ]. The organic PSs harbor the special merits of good biocompatibility and biodegradability.…”

Section: Reactive Oxygen Species-based Antitumor Therapymentioning

confidence: 99%

Photoactivatable nanogenerators of reactive species for cancer therapy

Zheng

Jin

Liu

et al. 2021

Bioactive Materials

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In recent years, reactive species-based cancer therapies have attracted tremendous attention due to their simplicity, controllability, and effectiveness. Herein, we overviewed the state-of-art advance for photo-controlled generation of highly reactive radical species with nanomaterials for cancer therapy. First, we summarized the most widely explored reactive species, such as singlet oxygen, superoxide radical anion (O 2 ●- ), nitric oxide ( ● NO), carbon monoxide, alkyl radicals, and their corresponding secondary reactive species generated by interaction with other biological molecules. Then, we discussed the generating mechanisms of these highly reactive species stimulated by light irradiation, followed by their anticancer effect, and the synergetic principles with other therapeutic modalities. This review might unveil the advantages of reactive species-based therapeutic methodology and encourage the pre-clinical exploration of reactive species-mediated cancer treatments.

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Peptide Mediated Chiral Inorganic Nanomaterials for Combating Gram‐Negative Bacteria

Cited by 32 publications

References 38 publications

In vivo activation of pH-responsive oxidase-like graphitic nanozymes for selective killing of Helicobacter pylori

In vivo activation of pH-responsive oxidase-like graphitic nanozymes for selective killing of Helicobacter pylori

In vivo activation of pH-responsive oxidase-like graphitic-nanozymes for selective killing of Helicobacter pylori

Photoactivatable nanogenerators of reactive species for cancer therapy

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