PEO-grafting on PU/PS IPNs for enhanced blood compatibility—effect of pendant length and grafting density

Kim, J.H.; Kim, Sung Chul

doi:10.1016/s0142-9612(01)00330-1

Cited by 79 publications

(41 citation statements)

References 25 publications

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“…Many kinds of surfaces with excellent biocompatibility, including poly(ethylene glycol)-grafted surfaces, [2][3][4] phase-separated microdomain surfaces, [5,6] bioactive molecule-incorporated surfaces, [7,8] and surfaces of zwitterionic compounds, [9][10][11][12][13][14] have been reported.…”

Section: Introductionmentioning

confidence: 99%

Anti‐Biofouling Properties of Polymers with a Carboxybetaine Moiety

Tada¹,

Inaba²,

Mizukami³

et al. 2008

Macromolecular Bioscience

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The resistance of random copolymers of BMA and CMB against biofouling was evaluated. The amount of proteins adsorbed onto the CMB copolymers was smaller than that onto other polymers (non-ionic polymers and copolymers of ordinary ionic monomers and BMA) and decreased with an increase in the content of CMB residues. Furthermore, there was a dramatic decrease in the number of cells (platelets and fibroblasts) that adhered to the CMB copolymers compared with that to other polymers. In contrast with this, CMB copolymers were slightly perturbative to both complement and coagulation systems. However, the overall results suggest that zwitterionic moieties are effective for making polymer materials biocompatible due to their excellent anti-biofouling property.

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Section: Introductionmentioning

confidence: 99%

Anti‐Biofouling Properties of Polymers with a Carboxybetaine Moiety

Tada¹,

Inaba²,

Mizukami³

et al. 2008

Macromolecular Bioscience

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“…Platelets also have a very important role in hemostasis and thrombogenesis. Platelet is a catalyzing coagulation reaction agent, which leads to the formation of fibrin, but does not react negatively with other blood cells [8]. Therefore, one of the requirements of polymeric materials for ABVs application is antithrombus property, including antiplatelet adhesion, and reduces blood protein (fibrinogen) attraction.…”

Section: Introductionmentioning

confidence: 99%

Fabrication of Polycaprolactone/Polyurethane Loading Conjugated Linoleic Acid and Its Antiplatelet Adhesion

Minh

Hiệp

Hai

et al. 2017

International Journal of Biomaterials

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Polycaprolactone/polyurethane (PCL/PU) fibrous scaffold was loaded with conjugated linoleic acid (CLA) by electrospinning method to improve the hemocompatibility of the polymeric surface. Fourier Transform Infrared Spectroscopy (FT-IR) analysis and Scanning Electron Microscopy (SEM) observation were employed to characterize the chemical structure and the changing morphology of electrospun PCL/PU and PCL/PU loaded with CLA (PCL/PU-CLA) scaffolds. Platelet adhesion and whole blood clot formation tests were used to evaluate the effect of CLA on antithrombotic property of PCL/PU-CLA scaffold. Endothelial cells (EC) were also seeded on the scaffold to examine the difference in the morphology of EC layer and platelet attachment with and without the presence of CLA. SEM results showed that CLA supported the spreading and proliferation of EC and PCL/PU-CLA surface induced lower platelet adhesion as well as attachment of other blood cells compared to the PCL/PU one. These results suggest that electrospinning method can successfully combine the antiplatelet effects of CLA to improve hemocompatibility of PCL/PU scaffolds for applications in artificial blood vessels.

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“…The cell attachment to the implant follows two main strategies for the cell-material interactions: one is by creating an inert surface that inhibits the cell attachment and proliferation, and the other is by creating a surface that promotes them. The implants constructed to fulfill the former criterion are used in the joint prostheses (as heads and cups) [1], blood-contacting devices (heart valves), smooth bioinert vascular prostheses, vesicles for drug delivery or catheters for hemodialysis [1][2][3][4][5] or intraocular lenses [6,7]. Those in the latter case are used in bone implants for the formation of osseous tissue [8][9][10] or skin substitutes made up of polymeric sheet with a feeder layer of fibroblasts that is covered by keratinocytes [11].…”

Section: Introductionmentioning

confidence: 99%