Anti‐Biofouling Properties of Polymers with a Carboxybetaine Moiety

Abstract

The resistance of random copolymers of BMA and CMB against biofouling was evaluated. The amount of proteins adsorbed onto the CMB copolymers was smaller than that onto other polymers (non-ionic polymers and copolymers of ordinary ionic monomers and BMA) and decreased with an increase in the content of CMB residues. Furthermore, there was a dramatic decrease in the number of cells (platelets and fibroblasts) that adhered to the CMB copolymers compared with that to other polymers. In contrast with this, CMB copolymers were slightly perturbative to both complement and coagulation systems. However, the overall results suggest that zwitterionic moieties are effective for making polymer materials biocompatible due to their excellent anti-biofouling property.

Bioprinting with pre-cultured cellular constructs towards tissue engineering of hierarchical tissues

“…Zwitterionic polymers, which have both anion and cation in a single molecule, are known as excellent bio-functional materials that prevent both cell adhesion and protein adsorption [17,18] , and are also useful for bio-patterning [19,20] . In this work, zwitterionic polymers were prepared using 1-carboxy-N,Ndimethyl-N-(2'-methacryloyloxyethyl)methanaminium inner salt also known as carboxymethyl betaine (CMB) was kindly donated from Osaka Organic Chemical Industry, Kashiwara, Japan, and n-butylmethacrylate (BMA) obtained from Wako, Osaka, Japan, at the rate of (CMB/BMA = 29/71; MW = 193 kDa and MW/Mn =1.92; 1 wt% ethanol solution), and utilized as a surface patterning material.…”

Self-association of zwitterionic polymer–lipid conjugates in water as examined by scattering measurements

“…Furthermore, 2-methacryloyloxyethylphosphorylcholine (MPC), a zwitterionic vinyl monomer analogous to a phosphorylcholine head group of a natural lipid, has been copolymerized with apolar monomers such as n-butyl methacrylate to afford excellent biocompatible properties such as resistance against non-specific protein adsorption, cell adhesion, and thrombus formation [13][14][15]. Similar properties have also been confirmed for other zwitterionic polymers such as poly(sulfobetaine)s and poly(carboxybetaine)s [16,17].…”

“…Since zwitterionic polymers are well known to have excellent biocompatibility (anti-biofouling and anti-thrombogenicity) [13][14][15][16][17], the present results will be useful for designing polymer-lipid conjugates that can be practically used in biomedical fields (e.g., DDS [71,72] and anti-fouling coating on biosensors with a large S/N ratio). At the modification of biosensors with zwitterionic polymer-lipid conjugates, furthermore, the ATR-IR technique would be quite helpful for analyzing the physi-sorption processes [43].…”

Image Printing on the Surface of Anti‐Biofouling Zwitterionic Polymer Brushes by Ion Beam Irradiation

“…The absorbance at 560 nm was measured using a microplate reader (see Figure 1 and S1, Supporting Information). [57,58] …”

“…[56,57] The usability of CMB/BMA copolymer as dressings for wound healing was also reported. [58] In addition, the solution behavior of zwitterionic polymers has received much attention due to the unique properties of typical polyelectrolytes.…”