Pentylenetetrazole kindling impairs long-term memory in rats

Genkova-Papazova, M.; Lazarova-Bakarova, M.

doi:10.1016/0924-977x(94)00134-w

Cited by 39 publications

(6 citation statements)

References 15 publications

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“…Besides using for inducing animal seizure models, PTZ, as a GABAa antagonist (Shimada & Yamagata, 2018), is routinely used for assessing learning and memory impairments following seizure events (Genkova-Papazova & Lazarova-Bakarova, 1995;Shaw & Webster, 1979).…”

Section: Discussionmentioning

confidence: 99%

Pentylenetetrazol and Morphine Interaction in a State-dependent Memory Model: Role of CREB Signaling

Tavassoli

Ardjmand

2020

Basic Clin. Neurosci. J.

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Introduction: State-dependent (STD) memory is a process, in which the learned information can be optimally retrieved only when the subject is in the state similar to the encoding phase. This phenomenon has been widely studied with morphine. Several studies have reported that Pentylenetetrazole (PTZ) impairs memory in experimental animal models. Due to certain mechanistic interactions between morphine and PTZ, it is hypothesized that PTZ may interfere with the morphine-STD. The cyclic adenosine monophosphate Response Element-Binding (CREB) is considered as the main downstream marker for long-term memory. This study was designed to determine the possible interaction between PTZ and morphine STD and the presumable changes in CREB mRNA. Methods: In an Inhibitory Avoidance (IA) model, posttraining morphine (2.5, 5, and 7.5 mg/ kg-i.p.) was used. The pre-test morphine was evaluated for morphine-induced STD memory. Moreover, the effect of a pre-test PTZ (60 mg/kg-i.p.) was studied along with morphine STD. Locomotion testing was carried out using open-field. Eventually, using real-time-PCR, the CREB mRNA changes in the hippocampus were evaluated. Results: Posttraining MOR (7.5 mg/kg-i.p.) impaired IA memory (P<0.001). The pre-test injection of similar doses of morphine recovered the morphine-induced memory impairment (P<0.001). The pre-test PTZ impaired the IA memory recall (P<0.001); however, the pre-test PTZ along with morphine STD potentiated the morphine-induced STD (P<0.001). Alterations in CREB mRNA were observed in all groups. No difference was seen in the locomotor activity. Conclusion: Presumably, the certain interactive effect of PTZ on morphine-induced STD is mediated through gamma-aminobutyric acid and opioid systems via CREB signaling.

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Section: Discussionmentioning

confidence: 99%

Pentylenetetrazol and Morphine Interaction in a State-dependent Memory Model: Role of CREB Signaling

Tavassoli

Ardjmand

2020

Basic Clin. Neurosci. J.

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“…In all of these cases, studies are presented showing either retrograde amnesia, anterograde amnesia, or both following periods of seizure activity. Studies in rats have assessed the relation between seizure activity and memory processes by manipulating the induction of seizure activity to affect the ability of a region such as the HPC or amygdala to consolidate or retrieve information, and this can be done pharmacologically [33], [34] or using electrical stimulation [24].…”

Section: Discussionmentioning

confidence: 99%

Suppression of Neurotoxic Lesion-Induced Seizure Activity: Evidence for a Permanent Role for the Hippocampus in Contextual Memory

et al. 2011

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Damage to the hippocampus (HPC) using the excitotoxin N-methyl-D-aspartate (NMDA) can cause retrograde amnesia for contextual fear memory. This amnesia is typically attributed to loss of cells in the HPC. However, NMDA is also known to cause intense neuronal discharge (seizure activity) during the hours that follow its injection. These seizures may have detrimental effects on retrieval of memories. Here we evaluate the possibility that retrograde amnesia is due to NMDA-induced seizure activity or cell damage per se. To assess the effects of NMDA induced activity on contextual memory, we developed a lesion technique that utilizes the neurotoxic effects of NMDA while at the same time suppressing possible associated seizure activity. NMDA and tetrodotoxin (TTX), a sodium channel blocker, are simultaneously infused into the rat HPC, resulting in extensive bilateral damage to the HPC. TTX, co-infused with NMDA, suppresses propagation of seizure activity. Rats received pairings of a novel context with foot shock, after which they received NMDA-induced, TTX+NMDA-induced, or no damage to the HPC at a recent (24 hours) or remote (5 weeks) time point. After recovery, the rats were placed into the shock context and freezing was scored as an index of fear memory. Rats with an intact HPC exhibited robust memory for the aversive context at both time points, whereas rats that received NMDA or NMDA+TTX lesions showed a significant reduction in learned fear of equal magnitude at both the recent and remote time points. Therefore, it is unlikely that observed retrograde amnesia in contextual fear conditioning are due to disruption of non-HPC networks by propagated seizure activity. Moreover, the memory deficit observed at both time points offers additional evidence supporting the proposition that the HPC has a continuing role in maintaining contextual memories.

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“…These impairments are prevalent in epileptic patient ( Holmes 1991 ; Mula & Trimble, 2009 ). Numerous studies in animal models have shown that kindling can increase hippocampal-dependent memory impairments, such as spatial memory in Morris Water Maze (MWM) ( Beldhuis, Everts, Van der Zee, Luiten, & Bohus, 1992 ; Gilbert, McNamaira, Corcoran, 1996 ; Cammisuli et al, 1997 ; Sutherland, Leung, Weisend, Schlife, & McDonald, 1997 ), working memory in Radial maze ( Leung, Boon, Kaibara, & Innis, 1990 ), and emotional memory in shuttle box ( Grecksch, Becker Gadau, & Matthies, 1991 ; Genkova-Papazova, 1995 ; Pohle, Becker, Grecksch, Juhre, & Willenberg, 1997 ; Hannesson, Howland, Pollock, Wallace, & Corcoran, 2001 ; Szyndler et al, 2002 ). As a new emerging approach, deep brain stimulation is used for the treatment of pharmacoresistant epilepsy ( Durand & Bikson, 2001 ; Li & Mogul, 2007 ; Fisher et al, 2010 ; Cukiert, Cukiert, Burattini, & Lima, 2014 ).…”

Section: Introductionmentioning

confidence: 99%

“…According to the literature, seizure can impair emotional learning and memory in passive and active avoidance paradigms in animal ( Grecksch et al, 1991 ; Genkova-Papazova, 1995 ; Pohle et al, 1997 ; Hannesson et al, 2001 ; Szyndler et al, 2002 ) and also emotional experience and behavior in human ( Cendes et al, 1994 ; Lanteaume et al, 2006 ). While previous studies have supported the improving effect of LFS on spatial learning and memory impairment (induced by kindling), a question is raised owning to the connections between hippocampus and amygdale.…”

Section: Introductionmentioning

confidence: 99%

Low Frequency Stimulation Reverses the Kindling-Induced Impairment of Learning and Memory in the Rat Passive-avoidance Test

Esmaeilpour

Sheibani

Shabani

et al. 2018

BCN

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Introduction:The life quality of patients with epileptic seizures is highly affected by cognitive deficits. Low Frequency Stimulation (LFS) is a novel approach for the treatment of pharmacoresistant epilepsy. The main goal of this research is investigating the possible effect of LFS on seizure-induced cognitive dysfunction.Methods:To this end, the kindled animal were prepared via CA1 electrical stimulation in a semi-rapid way (12 stimulations/day). A group of animals were stimulated with LFS, 4 times at 30 s, 6 h, 24 h, and 30 h after the last kindling stimulation. Applied LFS was administered in 4 packages every 5 minutes. The packages were designed with 200 monophasic 200 monophasic square wave pulses of 0.1 ms duration at 1 Hz. The passive-avoidance test was conducted on all animals in order to measure the learning and memory behavior.Results:Hippocampal kindled rats showed deficits in learning and memory when passive avoidance test was performed. Application of LFS reversed the impairment in learning and memory behavior in kindled rats. At the same time, LFS markedly diminished kindling-induced neuronal loss and atrophy in the hippocampus.Conclusion:LFS may have some protection against seizure-induced cognitive damage in kindled rats.

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Pentylenetetrazole kindling impairs long-term memory in rats

Cited by 39 publications

References 15 publications

Pentylenetetrazol and Morphine Interaction in a State-dependent Memory Model: Role of CREB Signaling

Pentylenetetrazol and Morphine Interaction in a State-dependent Memory Model: Role of CREB Signaling

Suppression of Neurotoxic Lesion-Induced Seizure Activity: Evidence for a Permanent Role for the Hippocampus in Contextual Memory

Low Frequency Stimulation Reverses the Kindling-Induced Impairment of Learning and Memory in the Rat Passive-avoidance Test

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