Pentraxin 3 in unstable angina and non-ST-segment elevation myocardial infarction

Matsui, Shigeru; Ishii, Junnichi; Kitagawa, Fumihiko; Kuno, Atsuhiro; Hattori, Kousuke; Ishikawa, Makoto; Okumura, Masanori; Kan, Shino; Nakano, Tadashi; Naruse, Hiroyuki; Tanaka, Ikuko; Nomura, Masatoshi; Hishida, Hitoshi; Ozaki, Yukio

doi:10.1016/j.atherosclerosis.2009.10.033

Cited by 86 publications

(79 citation statements)

References 22 publications

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“…[11] Hyperuricemia is recognized a good predictor of heart failure and death in patients after AMI. [12][13][14] Compared with such markers as brain natriuretic peptide and high-sensitivity C-reactive protein, which have been widely used in assessing the prognosis of AMI, [15,16] whether SUA could be an independent predictor of heart failure and death after myocardial infarction remains to be confi rmed by further studies.…”

Section: Discussionmentioning

confidence: 99%

Serum uric acid in patients with acute ST-elevation myocardial infarction

Chen

Qiao

et al. 2012

World Journal of Emergency Medicine

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Section: Discussionmentioning

confidence: 99%

Serum uric acid in patients with acute ST-elevation myocardial infarction

Chen

Qiao

et al. 2012

World Journal of Emergency Medicine

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“…20 In addition, neutrophils contain a store of mature protein in their specific granules and can promptly release the molecule in response to proinflammatory signals. 21 Pentraxin is also expressed in cardiac tissue after MI, [17][18][19][20][21][22] and its plasma concentration predicts cardiovascular morbidity and mortality in patients with unstable angina, 23 MI, 24 or heart failure. 25 As expected, we found that patients admitted to a rehabilitation program after cardiac surgery presented with high concentrations of the biomarkers related to cardiac stress or injury (brain natriuretic peptide, cardiac troponin-T, creatine kinase, and myoglobin), generalized inflammation and vascular injury (C-reactive protein and pentraxin-3), and early renal glomerular dysfunction (albumin urinary excretion), but the marked decrease in biomarker levels during rehabilitation supports the global effectiveness of even short-term programs.…”

Section: Discussionmentioning

confidence: 99%

Pentraxin-3 Predicts Functional Recovery and 1-Year Major Adverse Cardiovascular Events After Rehabilitation of Cardiac Surgery Patients

Ferratini

Ripamonti

Masson

et al. 2012

Journal of Cardiopulmonary Rehabilitation and Prevention

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■ BACKGROUND: Inflammatory and vascular markers have proved to be predictors of outcome in myocardial infarction and heart failure. We evaluated several circulating markers of cardiac stress, inflammation, and endothelial function to investigate their ability to predict short-term functional recovery and long-term clinical outcome in heart surgery patients undergoing inpatient rehabilitation.■ METHODS: This prospective, multicenter study enrolled 223 patients after heart surgery, included in a 3-week program of standardized and supervised physical training. The association between biomarkers (pentraxin-3 [PTX3], brain natriuretic peptide, high-sensitivity cardiac troponin-T [hs-cTnT] and C-reactive protein [hsCRP], creatine kinase, myoglobin, and urinary albumin excretion [UACR]) and exercise capacity (6-minute walk test, 6MWT) or 1-year incidence of major adverse cardiovascular events (MACE) was tested in models that included biohumoral markers, and clinical and instrumental variables.■ RESULTS: The patients (69.5% men, mean age of 67 Ϯ 11 years) were enrolled after valvular surgery (52.7%) and 58.6% after coronary artery bypass grafting (CABG

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“…It was determined that endothelial cells and macrophages are involved in the basic formation of atherosclerosis and that PTX-3 is secreted from atherosclerotic lesions (28). In the study by Matsui et al (29), elevated serum PTX-3 levels were related to USAP, STEMI, NSTEMI, cardiac failure, and negative cardiovascular events. Ustundag et al (30) determined the sensitivity and specificity of PTX-3 levels analyzed within the first 6 h to be 98.5% and 92.3%, respectively, in patients with ACS.…”

Section: Discussionmentioning

confidence: 99%