Pentraxin-3 Predicts Functional Recovery and 1-Year Major Adverse Cardiovascular Events After Rehabilitation of Cardiac Surgery Patients

Ferratini, Maurizio; Ripamonti, Vittorino; Masson, Serge; Grati, Paola; Racca, Vittorio; Cuccovillo, Ivan; Raimondi, Elena; Capomolla, Soccorso; Macchi, Claudio; Coruzzi, Paolo; Vago, Tarcisio; Calvo, Maria Gaetana; Mantovani, Alberto; Latini, Roberto

doi:10.1097/hcr.0b013e31823be0f4

Cited by 15 publications

(10 citation statements)

References 37 publications

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“…Also, the statistical power for detecting associations with decreasing biomarker levels was modest due to the smaller number of participants who have a decrease compared with an increase in their cTnT level. Our findings are in contrast to the beneficial effects of physical exercise that have been documented to lead to a marked decrease in NT-proBNP and hs cTnT levels after acute myocardial infarction or cardiac surgery hospitalization, respectively (33,34). However, in these patients, the baseline biomarkers were generally 9- to 10-fold higher at baseline than in our community-dwelling subjects and represent a more acute change in pathophysiology likely involving favorable left ventricular remodeling.…”

Section: Discussioncontrasting

confidence: 99%

Physical Activity, Change in Biomarkers of Myocardial Stress and Injury, and Subsequent Heart Failure Risk in Older Adults

deFilippi

Lemos

Tkaczuk

et al. 2012

Journal of the American College of Cardiology

110

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Objectives The aim of this study was to evaluate the association between physical activity and changes in levels of highly sensitive troponin T (cTnT) and N-terminal pro–B-type natriuretic peptide (NT-proBNP), and the subsequent risk of the development of heart failure (HF) in community-dwelling older adults. Background Higher baseline levels of cTnT and NT-proBNP and increases over time correlate with the risk of HF in older adults. Factors modifying these levels have not been identified. Methods NT-proBNP and cTnT were measured at baseline and 2 to 3 years later in adults 65 years of age and older free of HF participating in the Cardiovascular Health Study. Self-reported physical activity and walking pace were combined into a composite score. An increase was prespecified for NT-proBNP as a >25% increment from baseline to ≥190 pg/ml and for cTnT as a >50% increment from baseline in participants with detectable levels (≥3 pg/ml). Results A total of 2,933 participants free of HF had NT-proBNP and cTnT measured at both time points. The probability of an increase in biomarker concentrations between baseline and follow-up visits was inversely related to the physical activity score. Compared with participants with the lowest score, those with the highest score had an odds ratio of 0.50 (95% confidence interval: 0.33 to 0.77) for an increase in NT-proBNP and an odds ratio of 0.30 (95% confidence interval: 0.16 to 0.55) for an increase in cTnT, after adjusting for comorbidities and baseline levels. A higher activity score associated with a lower long-term incidence of HF. Moreover, at each level of activity, an increase in either biomarker still identified those at higher risk. Conclusions These findings suggest that moderate physical activity has protective effects on early heart failure phenotypes, preventing cardiac injury and neurohormonal activation.

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Section: Discussioncontrasting

confidence: 99%

Physical Activity, Change in Biomarkers of Myocardial Stress and Injury, and Subsequent Heart Failure Risk in Older Adults

deFilippi

Lemos

Tkaczuk

et al. 2012

Journal of the American College of Cardiology

110

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“…On the other hand, PTX3 specifically indicates the inflammation in the vascular bed displaying vascular injury in human body. Recent studies have highlighted the role of PTX3 in vascular inflammation and proved that PTX3 is a fundamental vascular inflammatory marker predicting the outcome of cardiovascular diseases and heart failure [28,29]. PTX3 is present in atherosclerotic lesions and in small-vessel vasculitis in humans [22,30].…”

Section: Discussionmentioning

confidence: 99%

Is There Any Relationship between Plasma Pentraxin 3 Levels and Gestational Diabetes Mellitus?

Yıldırım¹,

Simavlı²,

Derbent³

et al. 2015

Gynecol Obstet Invest

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Background: Pentraxin 3 (PTX3) is a novel vascular inflammatory marker which increases in vascular events such as diabetes mellitus. The aim of this study was to investigate the relationship between serum PTX3 levels and gestational diabetes mellitus (GDM). Methods: This prospective observational study was comprised of 88 pregnant women with singleton pregnancies. The subjects were classified into 3 groups according to their response to a 50-gram glucose challenge test (GCT) and a 100-gram oral glucose tolerance test: control group (n = 28), impaired glucose tolerance group (n = 30), and GDM group (n = 30). Serum PTX3 levels were measured to examine the relationship between GDM and GCT values. Results: Significant differences in PTX3 levels were observed among the 3 groups in the sample (F = 7.598; p = 0.001). The mean PTX3 value was found to be significantly higher in the GDM group (3.17 ± 1.16 ng/ml) than in the control group (2.20 ± 0.83 ng/ml; p = 0.001). A significant positive correlation between PTX3 and GCT values was detected (r = 0.289; p = 0.008). Conclusion: Maternal serum PTX3 levels were found to be significantly related to high blood glucose levels. This may be an indicator of vascular pathology in GDM around the time of an oral glucose tolerance test.

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“…Similar to S100A, previous reports have shown the clinical significance of pentraxin 3 in cardiovascular disease. [28][29][30] Furthermore, procalcitonin, a bacterial infection marker, has been reported to be a marker to predict cardiovascular events. 31 These novel and specific biomarkers are needed for the risk stratification of patients with cardiovascular disease.…”

Section: Discussionmentioning

confidence: 99%

S100A12 as a Marker to Predict Cardiovascular Events in Patients With Chronic Coronary Artery Disease

Saito

Hojo

Ogoyama

et al. 2012

Circ J

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Pentraxin-3 Predicts Functional Recovery and 1-Year Major Adverse Cardiovascular Events After Rehabilitation of Cardiac Surgery Patients

Cited by 15 publications

References 37 publications

Physical Activity, Change in Biomarkers of Myocardial Stress and Injury, and Subsequent Heart Failure Risk in Older Adults

Physical Activity, Change in Biomarkers of Myocardial Stress and Injury, and Subsequent Heart Failure Risk in Older Adults

Is There Any Relationship between Plasma Pentraxin 3 Levels and Gestational Diabetes Mellitus?

S100A12 as a Marker to Predict Cardiovascular Events in Patients With Chronic Coronary Artery Disease

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