Pentacyclic triterpenes modulate liposome membrane fluidity and permeability depending on membrane cholesterol content

Kaddah, Samar; Khreich, Nathalie; Kaddah, Fouad; Charcosset, Catherine; Greige‐Gerges, Hélène

doi:10.1016/j.ijpharm.2021.121232

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Effect Of Formulation Parameters On the Size Of Liposomes1

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2024

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Cited by 4 publications

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References 67 publications

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“…43 The phospholipid bilayer showed a high degree of stability, and the drug showed a small amount of leakage under the regulation of cholesterol. 44 Then the fixed concentration was controlled (AP-3 = 30 μM, ICG = 9.5 μM) and the cytotoxicity of control, Blank TSL, Blank TSL (+), AP-3 solution, AP-3/ICG solution, AP-3/ICG solution (+), ICG-TSL, ICG-TSL (+), AI-TSL and AI-TSL (+) was investigated (Fig. 3B).…”

Section: Resultsmentioning

confidence: 99%

“…The addition of cholesterol can regulate the fluidity of the phospholipid bilayer and reduce drug leakage. 35 The study on the effect of the ratio of phospholipid to cholesterol under fixed processing conditions (TFR = 40 mL min −1 , FRR = 3 : 1, TLC = 4 mg mL −1 ) showed that the increase in cholesterol concentration reduces the liposome size, but the PDI was not affected (Fig. 1A).…”

Section: Effect Of Formulation Parameters On the Size Of Liposomesmentioning

confidence: 95%

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