Penicillamine for treating rheumatoid arthritis

Suarez‐Almazor, María E.; Spooner, Carol; Belseck, Elaine

doi:10.1002/14651858.cd001460

Cited by 24 publications

(16 citation statements)

References 26 publications

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“…The most important benefit was for functional disability, with an effect size of −0.17. This compares with the following effect sizes for disease‐modifying drug treatments: −0.09 (95% CI −0.45, 0.27) for antimalarials (95); −0.19 (95% CI −0.39, 0.02) for auranofin (96); −0.29 (95% CI −0.77, 0.19) for penicillamine (97); −0.31 (95% CI −1.06, 0.44) for azathioprine (98); −0.78 (95% CI −1.10, −0.47) for cyclosporine (99); and −1.48 (95% CI −1.82, −1.14) for methotrexate (100). Glucocorticoids, when given in addition to disease‐modifying drugs, have an additional effect size of −0.57 (95% CI −0.92, −0.22) (101).…”

Section: Discussionmentioning

confidence: 92%

Systematic review of rheumatoid arthritis patient education

Riemsma¹,

Taal²,

Kirwan³

et al. 2004

Arthritis & Rheumatism

128

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Section: Discussionmentioning

confidence: 92%

Systematic review of rheumatoid arthritis patient education

Riemsma¹,

Taal²,

Kirwan³

et al. 2004

Arthritis & Rheumatism

128

View full text Add to dashboard Cite

“…QI‐1 (RA core data set) was formulated based on both scientific evidence and expert consensus (7, 18–21). QI‐2 (RA DMARD use) was based on scientific evidence from multiple studies demonstrating the efficacy of DMARD therapy in RA (7, 22–32). QI‐3 (intervention if RA worse) was also based on scientific evidence from numerous clinical trials (5, 33–48).…”

Section: Discussionmentioning

confidence: 99%

American college of rheumatology quality indicators for rheumatoid arthritis: Benchmarking, variability, and opportunities to improve quality of care using the electronic health record

Adhikesavan

Newman

Diehl

et al. 2008

Arthritis & Rheumatism

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Objective. To measure how rheumatologists across our health system performed with the American College of Rheumatology (ACR) quality indicators (QIs) for rheumatoid arthritis (RA) and methotrexate (MTX) drug safety, and to develop opportunities for improvement.Methods. An electronic health record (EHR) review of 1,062 unique RA patients seen by 15 rheumatologists in a 1-year period was performed. Percentage of each QI met, reasons why the metric was not met, and performance of rheumatologists based on years of experience were evaluated. Results. The percentage met was high for QI-2 (RA disease-modifying antirheumatic drug use; 94%), QI-3 (intervention if RA worse; 85%), and QI-4 (MTX risks discussion; 87%). Percentage met was lower for QI-1 (RA core data set; 69%), QI-5 (MTX baseline studies; 41%), and QI-6 (MTX followup studies; 46%). QI-1 and QI-5 were low due to most physicians missing a single test, and QI-6 was low because of few physicians driving the percentage down. Better QI performance was seen in rheumatologists with <10 years versus >10 years of experience for QI-1 (90% versus 64%; odds ratio [OR] 4.21, P ‫؍‬ 0.004) and QI-3 (96% versus 82%; OR 4.47, P ‫؍‬ 0.019). EHR chart review for this population required 179.3 hours. Conclusion. Measurement allows us to better understand the quality of care that we deliver. In this systematic benchmarking of the ACR QIs in a large RA cohort, performance was excellent in RA treatment-related QIs. Significant variability was noted in RA and MTX monitoring measures, which can be addressed using process redesign techniques.

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“…D -penicillamine is a penicillin derivative and the D -isomer of dimethylated cysteine that was originally used to treat rheumatoid arthritis, and is now used to treat Wilson Disease due to its ability to chelate accumulated copper, which is characteristic of this genetic disorder ( Suarez-Almazor et al., 2000 ; Litwin et al., 2019 ). D -penicillamine inhibits both CBS and CSE, but is approximately 30 times more selective against CSE (IC 50 of 270 μM) ( Brancaleone et al., 2016 ).…”

Section: H 2 S Research Tools: Inhibitors Of H mentioning

confidence: 99%

The Role of Host-Generated H2S in Microbial Pathogenesis: New Perspectives on Tuberculosis

Rahman

Glasgow

Nadeem

et al. 2020

Front. Cell. Infect. Microbiol.

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For centuries, hydrogen sulfide (H2S) was considered primarily as a poisonous gas and environmental hazard. However, with the discovery of prokaryotic and eukaryotic enzymes for H2S production, breakdown, and utilization, H2S has emerged as an important signaling molecule in a wide range of physiological and pathological processes. Hence, H2S is considered a gasotransmitter along with nitric oxide (•NO) and carbon monoxide (CO). Surprisingly, despite having overlapping functions with •NO and CO, the role of host H2S in microbial pathogenesis is understudied and represents a gap in our knowledge. Given the numerous reports that followed the discovery of •NO and CO and their respective roles in microbial pathogenesis, we anticipate a rapid increase in studies that further define the importance of H2S in microbial pathogenesis, which may lead to new virulence paradigms. Therefore, this review provides an overview of sulfide chemistry, enzymatic production of H2S, and the importance of H2S in metabolism and immunity in response to microbial pathogens. We then describe our current understanding of the role of host-derived H2S in tuberculosis (TB) disease, including its influences on host immunity and bioenergetics, and on Mycobacterium tuberculosis (Mtb) growth and survival. Finally, this review discusses the utility of H2S-donor compounds, inhibitors of H2S-producing enzymes, and their potential clinical significance.

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Penicillamine for treating rheumatoid arthritis

Cited by 24 publications

References 26 publications

Systematic review of rheumatoid arthritis patient education

Systematic review of rheumatoid arthritis patient education

American college of rheumatology quality indicators for rheumatoid arthritis: Benchmarking, variability, and opportunities to improve quality of care using the electronic health record

The Role of Host-Generated H2S in Microbial Pathogenesis: New Perspectives on Tuberculosis

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