Pengendalian Suhu Ultrasonikasi Pada Pelapisan Nanopartikel Magnet (Fe3O4) Dengan Kitosan

Sulungbudi, Grace Tj.; Wildan, Z L; Salam, Rohmad; Mujamilah, Mujamilah

doi:10.24817/jkk.v39i2.2838

Cited by 3 publications

(4 citation statements)

References 6 publications

(9 reference statements)

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“…Selanjutnya gelembung tersebut akan pecah ketika telah mencapai ukuran maksimal. Pada proses ini dapat memutus ikatan kimia bahan-bahan nanopartikel di sekitar gelembung sehingga diperoleh nanosfer berukuran kecil (Dua et al, 2012;Sulungbudi et al, 2017).…”

Section: Metode Pembuatan Sediaan Liposom Pada Ekstrak Yang Memiliki ...unclassified

Kajian Pengembangan Sediaan Liposom pada Ekstrak yang Memiliki Aktivitas sebagai Antioksidan

Astuti

Aryani

Rahma

2022

BCSP

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Abstract. Liposomes are drug delivery systems that can increase the stability of compounds, so that liposomes can be developed to protect antioxidant compounds. This study aims to determine the formulation and manufacturing method of liposomes in extracts that have antioxidant activity and the effect of liposomes on antioxidant activity of extracts. This study was conducted using the SLR (Systematic Literature Review) method. The results of the study showed that the development of liposome preparations on extracts that had antioxidant activity can be made with the main components of soy lecithin, egg yolk lecithin, and 1,2-Dipalmitoyl-sn-glysero-3-phosphocholine (DPPC). In addition, cholesterol can be added as membrane stabilization, Tween 80 and PEG 2000 as surfactants. Liposomes can be prepared by thin layer hydration method, the heating method, microfluiditation and ultrasonication, the SCCO2 GAS method, and ethanol injection. Liposome preparations can protect extracts that have antioxidant activity by increasing the percentage value of free radical inhibition by up to 8% when compared to extracts without modification of the liposome system. Abstrak. Liposom merupakan sistem penghantaran obat yang mampu meningkatkan stabilitas senyawa, sehingga liposom dapat dikembangkan untuk melindungi senyawa antioksidan. Kajian ini bertujuan untuk mengetahui formulasi dan metode pembuatan sediaan liposom pada ekstrak yang memiliki aktivitas antioksidan serta mengetahui pengaruh sediaan liposom terhadap aktivitas antioksidan pada ekstrak. Kajian ini dilakukan dengan metode SLR (Systematic Literature Review). Hasil kajian menunjukkan bahwa pengembangan sediaan liposom pada ekstrak yang memiliki aktivitas antioksidan dapat dibuat dengan komponen utama lesitin kedelai, lesitin kuning telur, dan 1,2-Dipalmitoyl-sn-glysero-3-fosfokolin (DPPC). Selain itu dapat ditambahkan kolesterol sebagai stabilisasi membran, Tween 80 dan PEG 2000 sebagai surfaktan. Liposom dapat dibuat dengan metode hidrasi lapis tipis, pemanasan, mikrofluiditasi dan ultrasonikasi, gas antisolvent SCCO2, dan injeksi etanol. Sediaan liposom dapat melindungi ekstrak yang memiliki aktivitas sebagai antioksidan dengan pengingkatan nilai persen inhibisi radikal bebas hingga 8% jika dibandingkan dengan ekstrak tanpa modifikasi sistem liposom.

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Section: Metode Pembuatan Sediaan Liposom Pada Ekstrak Yang Memiliki ...unclassified

Kajian Pengembangan Sediaan Liposom pada Ekstrak yang Memiliki Aktivitas sebagai Antioksidan

Astuti

Aryani

Rahma

2022

BCSP

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“…Ultrasonication was performed with time and temperature variation. In this study, variation of time used was 1-3 hours [9], while temperature was 40°C, 50°C, and 60°C [10]. After the ultrasonication process was completed, the next process was to separate the solvent and the solute from the material overnight to separate the impurity, where the impurities would float above and the graphite powder settled below.…”

Section: Ultrasonication Processmentioning

confidence: 99%

Analysis of the Effect of Temperature and Time for Ultrasonication on Graphite Structure

Kusumawati¹,

Nurhuda²

2019

Proceedings of the Mathematics, Informatics, Science, and Education International Conference (MISEIC 2019)

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Graphite is a carbon allotrope with special bonding characteristics. These bonds can be altered given ultrasonic waves to be another form of bond or loosened. Changes in bonds will cause changes in bond characteristics to other forms of carbon allotropes. By varying ultrasonication process (time and temperature), the change in bonding or functional groups could be analyzed by changes in the structure of carbon. The ultrasonication process resulted in the bonding of oxygen atoms, produced bonding of C atoms with O, either as single or double bond. The new bond formed was linearly proportional to change in ultrasonication time and temperature. C bond with O caused carbon to change into allotrope of graphite oxide carbon, this was supported by the results of Raman spectroscopy characterization, where the defect of carbon was increased compared to carbon without ultrasonication. The intensity of the defect increased from 60 a.u to 265 a.u.

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“…The magnetic colloid used was provided from the Advanced Materials and Technology Center Laboratory (PSTBM)-BATAN with 5 mg/mL magnetic nanoparticle concentration with water as a medium and chitosan as a coating [9]. The 8 rats (Wistar rats age 6 months; ± 275 grams weight; male sex) used were sterile mice from PT.…”

Section: Materials and Equipmentmentioning

confidence: 99%

“…Magnetic nanoparticle of Fe 3 O 4 , especially in bulk particle size, has ferromagnetic magnetic properties with saturated magnetization values reaching 92 emu / gram. In this study, we used ~ 20 nm Fe 3 O 4 particles coated with chitosan, which has superparamagetic properties with saturated magnetization, Ms = 74 emu / gram and 68 emu / gram for samples before and after chitosan coating respectively [9]. Chitosan coated nanoparticles were dispersed in water medium and formed stable magnetic colloid with magnetic nanoparticle concentration of 5 mg/ml.…”

Section: Blood Magnetism Analysismentioning

confidence: 99%

RAT BLOOD PROFILE EVALUATION AFTER Fe3O4/CHITOSAN COLLOID INJECTION

Karo

Azis

Wildan

et al. 2019

jsmi

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RAT BLOOD PROFILE EVALUATION AFTER Fe3O4/CHITOSAN COLLOID INJECTION. The application of iron oxide (Fe3O4) magnetic nanoparticles in the biomedical field is still being explored, mainly related to its toxicity and side effects. This article reported results of the study aimed at analyzing the effect of chitosan-coated magnetic nanoparticles (NPM-C) on rat blood profiles. Magnetic colloid as much as 1 ml (concentration of 5 mg NPM-C / mL aquabidest) for 1 kG rat body weight was injected through intra-venous to the treated rat group (4 Wistar rats aged 6 months; weight ± 275 grams; male sex) while another four rats injected with sterile aquabidest used as a control group. The blood taking from each group of rats was carried out on 1 day before injection and several days after injection (days 1, 7, 14, 21, 28) through veins in the tail. To these blood samples, a series of blood profile analyzes is carried out including basic hematology, blood chemistry, and fragility of the erythrocyte membrane. The results of the analysis showed no significant differences between blood profiles after treatment and control, which indicated that chitosan-coated magnetic nanoparticles did not trigger cellular stress responses in the blood. The stability of blood magnetism analyzed by VSM (Vibrating Sample Magnetometer) also shows that magnetic nanoparticles are detected in the blood and tend to decrease in number with increasing time, so it is thought that these nanoparticles can be degraded or have been distributed into organs. These stable properties are analyzed due to an existence of chitosan coating around magnetic nanoparticles. Based on this study it can be concluded that up to the given concentration limit, iron oxide nanoparticles coated by chitosan are not toxic and have the potential to be used as drug carriers, MRI contrast agents, and other biomedical applications.

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Pengendalian Suhu Ultrasonikasi Pada Pelapisan Nanopartikel Magnet (Fe3O4) Dengan Kitosan

Cited by 3 publications

References 6 publications

Kajian Pengembangan Sediaan Liposom pada Ekstrak yang Memiliki Aktivitas sebagai Antioksidan

Kajian Pengembangan Sediaan Liposom pada Ekstrak yang Memiliki Aktivitas sebagai Antioksidan

Analysis of the Effect of Temperature and Time for Ultrasonication on Graphite Structure

RAT BLOOD PROFILE EVALUATION AFTER Fe3O4/CHITOSAN COLLOID INJECTION

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