Pengaruh Pemberian Sabun Cair Pembersih Kewanitaan Ekstrak Daun Iler (Coleus scutellariodes L.) Terhadap Pertumbuhan Candida albicans

Abstract

Leucorrhoea is one of the many disorders of the reproductive organs in women caused by a fungus which is characterized by excessive discharge of fluid in the female organs, causing an unpleasant odor. The fungus Candida albicans is a normal flora found in the female genitalia that causes vaginal discharge. Iler leaves (Coleus scutellariodes L) contain active components, including: flavonoids, tannins, triterpenoids, steroids and volatile oils that have antimicrobial properties. The purpose of this study was to determine the effect of giving female cleansing liquid soap containing slobber leaf extract on the growth of the fungus Candida albicans and to determine the optimal concentration that can inhibit / kill the growth of the fungus Candida albicans. The type of research carried out was a laboratory experiment. , the material used as the active substance is slobber leaves then extracted by maceration using a liquid extract, namely 96% v/v alcohol, the liquid extract obtained was stiffened by evaporation to obtain a thick extract. The active substance of slobber leaf extract is used in the manufacture of liquid soap for feminine hygiene with varying levels of 1%, 2%, and 4%. The feminine cleansing soap that has been made is then tested for the quality of the preparations, including pH and organoleptic testing, while testing its antifungal power against the growth of the fungus Candida albicans using the disk diffusion method (Test Kirby and Bauer). Based on the results of the study, it was shown that female cleansing liquid soap containing the active substance of Iler leaf extract at a concentration of 4% could inhibit/kill the growth of the Candida albicans fungus optimally when compared to concentrations of 1% and 2%, but the effect was still lower than of positive control ( p<0.05).

FORMULASI SEDIAAN SABUN PEMBERSIH KEWANITAAN EKSTRAK DAUN MANGGA ARUM MANIS (Mangifera indica L.) TERHADAP PERTUMBUHAN Candida albicans

“…Selanjutnya, pada pengamatan warna sediaan pada F0 tidak berwarna dan jernih. Pada F0, F2, F3 dapat dilihat bahwa semakin tinggi konsentrasi ekstrak maka semakin pekat warna coklat yang dihasilkan (Jumain & Asmawati, 2021). Berdasarkan hasil pengujian organoleptik sebelum dan sesudah cycling test tidak ditemukan perubahan bentuk, warna, dan bau sehingga dapat dinyatakan bahwa sediaan yang dihasilkan secara organoleptik relatif stabil karena tidak terpengaruh oleh perubahan suhu pada saat penyimpanan.…”

“…Nilai pH sediaan yang dibuat mendekati nilai pH dari kontrol positif (Lactacyd®) yaitu 4,1. Nilai pH mengalami penurunan sesudah penyimpanan, tetapi masih memenuhi persyaratan nilai pH organ kewanitaan yaitu 3,5-4,5 (Jumain & Asmawati, 2021). Perubahan tersebut bisa dipengaruhi oleh lama penyimpanan yang menyebabkan basis sediaan mengalami penguraian, terjadinya autooksidasi pada saat penyimpanan, serta berbagai faktor lainnya seperti suhu, kelembaban, dan cahaya (Asjur et al, 2022) Homogen Homogen…”