Pengaruh Pemberian Ekstrak Dandang Gendis (Clinacanthus nutans) Terhadap Kadar Glukosa Darah pada Tikus Wistar Model Diabetes Melitus

Dewinta, Nena Ristra; Mukono, Indri Safitri; Mustika, Arifa

doi:10.20473/jmv.vol3.iss1.2020.76-81

Cited by 11 publications

(12 citation statements)

References 16 publications

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“…Previous research by Dewinta et al in 2020 that the administration of ethanol extract of dandang gendis leaves (Clinacanthus nutans) has potential as an antidiabetic by lowering blood sugar levels in diabetic white Wistar rats. This is because the leaves of dandang gendis (Clinacanthus nutans) contain flavonoids and fatty acids as antioxidants that can lower blood sugar levels (Dewinta et al, 2020). Another research conducted by Panggabean et al in 2014 examined the "Activity Test of Increasing Insulin Sensitivity of Black Cumin Seed Extract (Nigella sativa) Through Measurement of Tyrosine Concentration Phosphorylated Insulin Receptor Substrate-1 (IRS-1)" that the administration of black cumin extract which has various contents, one of which is palmitic acid can increase insulin sensitivity and lower blood glucose levels.…”

Section: Ligand-receptor Molecular Docking Test Resultsmentioning

confidence: 99%

Analysis of Antidiabetic Potential of Palmitic Acid Compounds Through In Silico Activation

Salsabila

Susanti

Ulhaq

2022

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Diabetes Mellitus is a condition where the body's sugar level exceeds the blood's normal limit. Type 2 Diabetes Mellitus is the most common type of diabetes and is a chronic disease caused by insulin resistance and beta-cell dysfunction, resulting in decreased insulin sensitivity. The management of diabetes Mellitus is in the form of oral hypoglycemic drugs. Still, these drugs have side effects such as gastrointestinal disturbances, nausea, vomiting, hypoglycemia, macrovascular disorders, microvascular disorders, etc. So, it is necessary to seek alternative drugs to increase insulin sensitivity to lower blood sugar levels which are safer using herbal plants. One of the suspected plants that can be an alternative medicine to reduce excess blood sugar levels is the dandang gendis plant (Clinacanthus nutans). The dandang gendis plant (Clinacanthus nutans) contains palmitic acid, which can reduce excess blood sugar levels in the blood. This study aims to determine the potential of palmitic acid compounds from the Dandang gendis plant as an in silico AMPK protein activator. Methods: Qualitative descriptive method using molecular docking in silico method to determine the affinity and interaction with palmitic acid compounds in the dandang gendis plant in activating AMPK protein. Docking between palmitic acid and AMPK produces an energy value (∆Gbind) of -5.3 kcal/mol. docking of metformin resulted in the lowest energy value (∆Gbind) of 5.1 kcal/mol. The bond produced by palmitic acid docking has a fairly strong affinity for the AMPK protein of -5.3 kcal/mol. So palmitic acid, an ingredient in the dandang gendis plant (Clinacanthus nutans) has the potential as an antidiabetic.

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Section: Ligand-receptor Molecular Docking Test Resultsmentioning

confidence: 99%

Analysis of Antidiabetic Potential of Palmitic Acid Compounds Through In Silico Activation

Salsabila

Susanti

Ulhaq

2022

planar

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“…Groups V, VI, and VII were given belalai gajah plants extract at doses of 75 mg/kg body weight, 150 mg/kg body weight, and 300 mg/kg body weight. The dose of belalai gajah plants extract refers to Dewinta et al (2020) 42 and diuretic testing following the Cumming method. 49 Mice were fasted for ± 18 hours, then their body weight was weighed.…”

Section: Testing the Diuretic Activity Of Belalai Gajah Plantsmentioning

confidence: 99%

“…[33][34][35][36][37][38][39][40][41] Previous studies have shown that giving (belalai gajah plants) plants at a dose of 75 mg/kg body weight can significantly reduce blood glucose levels in diabetic rats. 42 Previously it was reported that administration of aqueous extract of belalai gajah plants at a dose of 150 mg/kg body weight resulted in a decrease in blood glucose levels in diabetic mice by alloxan induction. 43 In addition, it was also reported that administration of aqueous extract of belalai gajah plants at a dose of 75 mg/kg BW was effective in reducing blood glucose levels in diabetic rats.…”

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confidence: 99%

Diuretic Potency of Belalai Gajah Plants (Clinacanthus nutans (Burm.fil.) Lindau)

Panjaitan¹,

Afandi²,

Aprilia³

2023

Pharmacogn J.

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Hypertension is a major risk factor for cardiovascular disease and chronic kidney disease, the leading cause of death globally. 1 Hypertension or high blood pressure is a condition where after two separate measurements there is an increase in systolic blood pressure ≥140 mmHg and/or diastolic ≥90 mmHg. [2][3][4] If left unchecked, this disease can interfere with the function of other organs such as the heart and kidneys which are vital organs. 5 Symptoms that can be caused in people with hypertension are chest pain, vision problems, ringing in the ears, fatigue, confusion, headache, feeling of heaviness in the back of the neck, vertigo, nosebleeds, dyspnea/ shortness of breath, increased frequency of urine, nausea, sleep apnea, irregular heartbeat regular. 6,7 Factors that cause hypertension are age, family history, being overweight/obese, not being physically active, using tobacco, consuming too much salt (sodium) in the food consumed, too little potassium in the food consumed, consuming too much alcohol. 8 Hypertension often occurs in patients with chronic kidney disease. Hypertension management is needed to control blood pressure and prevent complications. Prevention of hypertension can be done with non-pharmacological efforts such as weight loss and limiting salt intake. As for pharmacological treatment such as therapy with antihypertensive drugs, one of which is diuretics. 7 Diuretics are drugs that can increase urine production due to the excretion of water and electrolytes by the kidneys. 10,11 The accumulation of fluid in the body's tissues is due to the inability of the kidneys to release sodium and water which are excreted together. Diuretics can be used to treat edema, heart failuure, and hypertension. 11 Diuretics can be categorized into three groups: loop diuretics, thiazide diuretics, and potassium-sparing diuretics. [12][13][14] Diuretics are used to improve the composition and volume of fluids in the body, which treats hypertension. 15,16 The mechanism of action of diuretic drugs in lowering blood pressure is by helping the kidneys function in filtering, removing salt and water, which in turn reduces the volume of fluids in the body so that blood pressure also decreases. 7,17 Hypertension is generally treated using synthetic drugs such as furosemide. [18][19][20][21] Furosemide is a loop diuretic that can reduce the reabsorption of sodium produced by the kidneys. Furosemide can inhibit the luminal Na-K-Cl co-transporter in the loop of Henle by binding to the chloride transport channel. In this case, elevated levels of Na, Cl, and K remain in the urine. 22 Long-term use of furosemide is known to cause electrolyte balance disturbances (excessive loss of sodium and potassium),

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“…Three days after induction, the rats were checked for blood glucose levels using a glucometer. The rats were declared to have diabetes if their blood glucose levels were ≥200 mg/dL and were called the diabetic rat model [18,[26][27][28].…”

Section: Animal Modelsmentioning

confidence: 99%

The self-nanoemulsifying drug delivery system of Petiveria alliacea extract reduced the homeostatic model assessment-insulin resistance value, interleukin-6, and tumor necrosis factor-α level in diabetic rat models

2021

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Background and Aim: Metaflammation plays a significant role in the pathogenesis, development, and complication of diabetes mellitus (DM). This inflammation is associated with insulin resistance. Therefore, the inflammatory pathways have been targeted for pharmacological treatment. Petiveria alliacea can decrease blood glucose levels and has anti-inflammatory and antioxidant activities; however, there are still insufficient data regarding its efficacy for the treatment of DM. This study aimed to investigate the effect of the self-nanoemulsifying drug delivery system (SNEDDS) of P. alliacea leaf extract on the homeostatic model assessment (HOMA)-insulin resistance (IR) value and interleukin (IL)-6 and tumor necrosis factor-α (TNF-α) levels in a streptozotocin (STZ)-induced diabetic rat model. Materials and Methods: Thirty-five diabetic rat models were randomly divided into five groups. The first group received the SNEDDS of P. alliacea leaf extract at a dose of 50 mg/kg body weight (BW), the second group received it at a dose of 100 mg/kg BW, the third group received it at a dose of 200 mg/kg BW, the fourth group received 18 mg of metformin, and the fifth group only received the SNEDDS formula. The treatment was administered once a day, orally, for 14 days. On the 15th day after treatment, the rats were sacrificed to obtain blood samples for cardiac examination. The IL-6, TNF-α, and insulin levels in the serum were measured using the enzyme-linked immunosorbent assay method. The HOMA-IR value was calculated using a formula. Results: The mean IL-6 and TNF-α levels were low in the group that received the SNEDDS of P. alliacea leaf extract. There was no significant difference in the insulin level in all treatment and control groups. However, a significant difference in the HOMA-IR value was noted between the group that received the SNEDDS of P. alliacea leaf extract and metformin and the group that did not receive treatment (p<0.05). Conclusion: The SNEDDS of P. alliacea leaf extract reduced the HOMA-IR value and suppressed the TNF-α and IL-6 levels in the STZ-induced diabetic rat model.

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Pengaruh Pemberian Ekstrak Dandang Gendis (Clinacanthus nutans) Terhadap Kadar Glukosa Darah pada Tikus Wistar Model Diabetes Melitus

Cited by 11 publications

References 16 publications

Analysis of Antidiabetic Potential of Palmitic Acid Compounds Through In Silico Activation

Analysis of Antidiabetic Potential of Palmitic Acid Compounds Through In Silico Activation

Diuretic Potency of Belalai Gajah Plants (Clinacanthus nutans (Burm.fil.) Lindau)

The self-nanoemulsifying drug delivery system of Petiveria alliacea extract reduced the homeostatic model assessment-insulin resistance value, interleukin-6, and tumor necrosis factor-α level in diabetic rat models

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