Pengaruh Pemberian Ekstrak Buah Naga Merah (Hylocereus polyrhizus) Terhadap Gambaran Spermatogenesis Tikus Putih (Rattus norvegicus) Galur Wistar yang Diinduksi Pakan Tinggi Lemak

Abstract

Spermatogenesis can be affected by oxidative stress produced by the increasing of pro-inflammatory adipokines because of high fat diet.The spermatogenesis cells damaged can be prevented with natural substance such as red pitaya (Hylocereus polyrhizus). This study aims to analyze effect of Hylocereus polyrhizus extract on rat’s spermatogenesis cells number that induced by high fat diet. This study had used true-experiment design. 30 rats were divided into 5 groups. Groups 1 to 4 had done treatment for 52 days and group 5 treatment for 104 days. Group 1 Negative control (K1) administered with standard diet, group 2 Positive control (K2) had administered quail egg 10ml/KgBW, group 3 Experiment 1 (P1) had administered quail egg polyrhyzus 10ml/Kg BW and with simvastatin 0,72mg/day, group 4 Experiment 2 (P2) had administered quail egg 10ml/KgBW and wth Hylocereus polyrhizus extract 60mg/day in 52 days, and group 5 Experiment 3 (P3) had administered quail egg 10ml/KgBW and with Hylocereus polyrhizus extract 60mg/day in 104 days. Data were analyzed by One Way ANOVA and continued with Post Hoc Tukey’s HSD (P-Value=0,05) for 52 day groups. Group P1 and P2 showed repairing effect and increasing spermatocytes and spermatids (p.000<0,05) compared to group K2. Group P2 had more spermatids and spermatocytes than group P1 (p.000<0,05). Group P2 52 days’ spermatid cells equalled to group P3 104 days (p.469>0,05). Hylocereus polyrhizus extract not only had mechanism like simvastatin but also contained antioxidant, and a long-term treatment had not proven bad effect to spermatogenesis cells. Conclusion. Hylocereus polyrhizus extract 60mg/day can repair and increase spermatogenesis cells induced with high fat diet.

Red dragon (Hylocereus polyrhizus) fruit peel extract increased the motility and viability of spermatozoa of hypercholesterolemic rats (Rattus norvegicus)

“…The RDFPE of 1000 mg/kg BW was proved to be the optimum dose to restore spermatozoa viability and motility in hypercholesterolemia rats, similar to spermatozoa viability and motility after treatment with Simvastatin at a dose of 10 mg/kg BW. These results were similar to those of ethanolic extract of Hylocereus polyrhizus peel orally, which showed an increase in spermatozoa count, spermatozoa viability (Aziz and Noor, 2010), and spermatogenesis cells in rats induced by a high-fat diet (Cantika et al, 2019).…”

Sensory Evaluation of Gulu Naga Ijo as a Complementary Finger Food Product

“…Green bean flour is added to complete the protein content alongside corn flour (12). Dragon fruit flour in making finger food as a natural coloring agent not only enhances visual appeal but also contributes to the elevated levels of antioxidants (13). Eggs, which have a delicious taste and high nutritional value, are included in the finger food recipe as a source of animal protein (14).…”