Pengaruh Antosianin Ubi Ungu terhadap TNF-Î±, Apoptosis dan Memori Spasial Hipokampus Tikus Model Diabetes Melitus

Darwatik, Darwatik; Ratnawati, Retty; Rianawati, Sri Budhi; Sarwono, Imam

doi:10.21776/ub.jkb.2018.030.01.3

Cited by 2 publications

(2 citation statements)

References 1 publication

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“…38 Studies conducted by Darwatik et al and Prabawati et al showed that diabetic rats had significantly different mean travel time with healthy controls after the diabetic group rats were given hyperglycemia exposure for 6 weeks, 2 weeks longer than the current study. 27,28 There is currently no ideal time reference for exposure to hyperglycemia in diabetic rats that can significantly influence the cognitive function of these experimental animals.…”

Section: Discussionmentioning

confidence: 99%

“…26 However, these technical difficulties can be overcome by replacing this parameter with another one, called travel time, which measure the time taken by the rat when starting to swim until it reach the platform. 27,28 This study aims to investigate the effect of GLUT4 expression on hippocampal neurons on the spatial memory of Rattus novergicus rats induced diabetes by injection of streptozotocin and nicotinamide. This was our effort to prove the role of GLUT4 in the pathomechanism of diabetes-associated cognitive decline.…”

Section: Research Article Open Accessmentioning

confidence: 99%

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The Effect of Glut4 Expression in Hippocampal Neurons to Spatial Memory of Diabetes-Induced Rattus Novergicus

Harahap

Padauleng

Lestari

et al. 2021

MNJ

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Background: Identification of appropriate biomarker involved in the pathophysiology of diabetes-associated cognitive decline in animal model is necessary. Glucose transporter 4 (GLUT4) is the component of insulin-dependent neuronal signaling pathway needed for maintaining cognitive function. It is highly expressed in hippocampal neurons. Objective: To investigate the effect of GLUT4 expression in hippocampal neurons on the spatial memory of diabetes-induced Rattus novergicus. Methods: This experimental study used 24 male Rattus novergicus divided into control groups terminated on day-0 (C0), 14 (C1) and 28 (C2) and diabetic groups terminated on day-0 (D0), 14 (D1) and 28 (D2). Diabetes was induced using streptozotocin injections intraperitoneally. Spatial memory (travel time) of rats was assessed on day-14 and 28. Brain tissue sampling was performed for assessment of GLUT4 expression using immunohistochemical methods. Significant differences in means of GLUT4 expression and travel time between groups on day-0, 14 and 28 as well as correlation between means of GLUT4 expression and travel time in D1 and D2 were analyzed statistically. Results: The mean of GLUT4 expression in diabetic group was significantly higher compared to control on day-14, but not on day-0 and 28. The immunohistochemical examination confirmed this results. There were no significant differences in mean of travel time between control and diabetic groups on day-14 and 28. There were no significant correlation between means of GLUT4 expression and travel time in diabetic groups on day-14 and 28. Conclusion: The GLUT4 expression of hippocampal neurons did not significantly affect spatial memory of diabetes-induced Rattus novergicus.

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Section: Discussionmentioning

confidence: 99%

Section: Research Article Open Accessmentioning

confidence: 99%

The Effect of Glut4 Expression in Hippocampal Neurons to Spatial Memory of Diabetes-Induced Rattus Novergicus

Harahap

Padauleng

Lestari

et al. 2021

MNJ

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Consumption of Purple Sweet Potato Snack Bar and Self Help Group for Blood Glucose Levels in Patients Diabetes Mellitus Type 2

Herikzah,

Pudiastuti,

Widiyanto

2024

International Journal of Innovative Science and Research Techno

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Background: Diabetes Mellitus is one of the most common chronic diseases in the world, occurs when insulin production in the pancreas is insufficient or when insulin cannot be used effectively by the body, so that blood sugar levels exceed the normal range. The increase in the prevalence of diabetes mellitus from year to year has increased significantly. Currently, diet management, exercise and the use of pharmacological therapy are options in the management of diabetes mellitus. In addition to this therapy, there is therapy by giving purple sweet potato snack bars and self help groups. Purpose: to prove the effectiveness of the intervention of a combination of purple sweet potato snack bar and self help group on fasting blood glucose levels of respondents with diabetes mellitus.Methods: This research is a true experimental study with a pretest-posttest design. This study had 60 respondents who were divided into 2 groups and were taken using non-probability sampling techniques with the stratified random sampling method. The study was conducted on March 12, 2022 – June 3, 2022. In this study, statistical analysis was carried out computerized. The pre-test post-test difference test uses the Wilcoxon test. Difference test between groups using Mann-Whitney. Results: This study showed that a significant difference before being given treatment with purple sweet potato snack bars 2x32 grams/3 days a week for 21 days and self-help group therapy for 3 meetings in 21 days showed a significant decrease from 173.30 mg/dl. to 130.03 mg/dl with a delta difference of - 43.267 mg/dl in the intervention group, while the control group also decreased after giving self help group therapy for 3 meetings in 21 days showing a decrease from 189.53 mg/dl to 163.83 mg/dl with a delta difference of -25,700 mg/dl (p = 0.033). Conclusion: Treatment in the form of purple sweet potato snack bar intervention and self help group had an effect on reducing fasting blood sugar levels of respondents with type II diabetes mellitus. type II diabetes mellitus patient.

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Pengaruh Antosianin Ubi Ungu terhadap TNF-Î±, Apoptosis dan Memori Spasial Hipokampus Tikus Model Diabetes Melitus

Cited by 2 publications

References 1 publication

The Effect of Glut4 Expression in Hippocampal Neurons to Spatial Memory of Diabetes-Induced Rattus Novergicus

The Effect of Glut4 Expression in Hippocampal Neurons to Spatial Memory of Diabetes-Induced Rattus Novergicus

Consumption of Purple Sweet Potato Snack Bar and Self Help Group for Blood Glucose Levels in Patients Diabetes Mellitus Type 2

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