Penetration of moxifloxacin into liver tissue

Justinger, Christoph; Schilling, Martin K.; Kees, Martin G.; Kauffels, Anne; Hirschmann, Katrin; Kopp, Berit; Kees, Frieder; Kollmar, Otto

doi:10.1016/j.ijantimicag.2012.01.022

Cited by 4 publications

(4 citation statements)

References 26 publications

(31 reference statements)

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“…However, the plasma level of a drug is often not predictive of the concentration achieved in the tissue where the drug is acting. There appear to be few clinical studies that examined the correlation between the drug plasma level and its concentrations in tissue (Wacke et al, 2006; Wagenlehner et al, 2006; Wirtz et al, 2004; Justinger et al, 2012). This is understandable since practical and ethical reasons explain why such important studies are so rare.…”

Section: Drug Distribution In Human Tissuesmentioning

confidence: 99%

The Space Dimension at the Micro Level: Mass Spectrometry Imaging of Drugs in Tissues

Davoli

Zucchetti

Matteo

et al. 2020

Mass Spectrometry Reviews

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Mass spectrometry imaging (MSI) has seen remarkable development in recent years. The possibility of getting quantitative or semiquantitative data, while maintaining the spatial component in the tissues has opened up unique study possibilities. Now with a spatial window of few tens of microns, we can characterize the events occurring in tissue subcompartments in physiological and pathological conditions. For example, in oncology—especially in preclinical models—we can quantitatively measure drug distribution within tumors, correlating it with pharmacological treatments intended to modify it. We can also study the local effects of the drug in the tissue, and their effects in relation to histology. This review focuses on the main results in the field of drug MSI in clinical pharmacology, looking at the literature on the distribution of drugs in human tissues, and also the first preclinical evidence of drug intratissue effects. The main instrumental techniques are discussed, looking at the different instrumentation, sample preparation protocols, and raw data management employed to obtain the sensitivity required for these studies. Finally, we review the applications that describe in situ metabolic events and pathways induced by the drug, in animal models, showing that MSI makes it possible to study effects that go beyond the simple concentration of the drug, maintaining the space dimension. © 2020 John Wiley & Sons Ltd. Mass Spec Rev

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Section: Drug Distribution In Human Tissuesmentioning

confidence: 99%

The Space Dimension at the Micro Level: Mass Spectrometry Imaging of Drugs in Tissues

Davoli

Zucchetti

Matteo

et al. 2020

Mass Spectrometry Reviews

View full text Add to dashboard Cite

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“…Moxifloxacin is a fluoroquinolone with excellent activity against a broad spectrum of microorganisms involved in soft tissue infections [ 1 ]. Total tissue concentrations of moxifloxacin reach or exceed the corresponding plasma concentrations [ 2 ]. However, concentrations determined in tissue homogenate should be interpreted with caution, most importantly because no distinction can be made between the intra- and extracellular concentrations [ 3 ], [ 4 ].…”

Section: Introductionmentioning

confidence: 99%

Decreased protein binding of moxifloxacin in patients with sepsis?

Dorn

Nowak

Weidemann

et al. 2017

GMS Infectious Diseases; 5:Doc03

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“…Almost the whole range of fluoroquinolones with similar structures and correspondingly close retention parameters in chro matographic columns were used as internal standards in determining moxifloxacin. Sarafloxacin [14,20], enrofloxacin [12], norfloxacin [1,15], lomefloxacin [16], gatifloxacin [6,7,17], and ofloxacin [4,10,11,19] were among them. A comparison of the methods of moxifloxacin determination in blood plasma is pre sented in Table 2.…”

mentioning

confidence: 99%

“…1). Various biological objects, such as urine [4][5][6], blood serum [2,7] and plasma [1,4,6,[8][9][10][11][12][13][14][15][16][17][18], saliva [4,19], and even lacrimal fluid [20] were studied. Monitoring of moxifloxacin concentration in blood plasma for attaining the optimum dosage conditions and the pre Square wave pulse voltammetry [5], capillary elec trophoresis [8], atomic adsorption spectrometry, con ductometry, and photometry [21] are among the described methods of moxifloxacin determination.…”

mentioning

confidence: 99%

A chromatographic-mass spectrometric method for the determination of moxifloxacin in blood plasma for pharmacokinetic studies

Yaroshenko

Khaimenov²,

Grigor’ev

et al. 2015

J Anal Chem

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A method for the determination of moxifloxacin in human blood plasma has been developed and validated by reversed phase HPLC on a YMC Triart C18 (150 × 2.0 mm, 3 µm) column with mass spectro metric detection. Sample preparation has been performed by solid phase extraction on Waters Sep Pak car tridges. The recovery of moxifloxacin was 90 ± 3%. A quadrupole mass analyzer with electrospray ionization has been used for detection at m/z 402.2 and 362.2 for moxifloxacin and ofloxacin (internal standard), respec tively. The lower limit of the analytical range was 1 ng/mL. The developed method has been used for the phar macokinetic study of moxifloxacin.

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Penetration of moxifloxacin into liver tissue

Cited by 4 publications

References 26 publications

The Space Dimension at the Micro Level: Mass Spectrometry Imaging of Drugs in Tissues

The Space Dimension at the Micro Level: Mass Spectrometry Imaging of Drugs in Tissues

Decreased protein binding of moxifloxacin in patients with sepsis?

A chromatographic-mass spectrometric method for the determination of moxifloxacin in blood plasma for pharmacokinetic studies

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