A method for the determination of moxifloxacin in human blood plasma has been developed and validated by reversed phase HPLC on a YMC Triart C18 (150 × 2.0 mm, 3 µm) column with mass spectro metric detection. Sample preparation has been performed by solid phase extraction on Waters Sep Pak car tridges. The recovery of moxifloxacin was 90 ± 3%. A quadrupole mass analyzer with electrospray ionization has been used for detection at m/z 402.2 and 362.2 for moxifloxacin and ofloxacin (internal standard), respec tively. The lower limit of the analytical range was 1 ng/mL. The developed method has been used for the phar macokinetic study of moxifloxacin.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.