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A method for the determination of moxifloxacin in human blood plasma has been developed and validated by reversed phase HPLC on a YMC Triart C18 (150 × 2.0 mm, 3 µm) column with mass spectro metric detection. Sample preparation has been performed by solid phase extraction on Waters Sep Pak car tridges. The recovery of moxifloxacin was 90 ± 3%. A quadrupole mass analyzer with electrospray ionization has been used for detection at m/z 402.2 and 362.2 for moxifloxacin and ofloxacin (internal standard), respec tively. The lower limit of the analytical range was 1 ng/mL. The developed method has been used for the phar macokinetic study of moxifloxacin.