Penetrating-peptide-mediated non-invasive Axitinib delivery for anti-neovascularisation

Huang, Yanlei; Zhu, Yutuo; Cai, Danyang; Guo, Qi; Wang, Jiaqing; Lei, Lei; Li, Xingyi; Shi, Shuai

doi:10.1016/j.jconrel.2022.05.009

Cited by 11 publications

(5 citation statements)

References 26 publications

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“…Tube formation of endothelial cells is one of the critical steps in the formation of new blood vessels . Here, the antiangiogenic effect of compounds was preliminarily evaluated by tube formation assay.…”

Section: Resultsmentioning

confidence: 99%

“…Tube formation of endothelial cells is one of the critical steps in the formation of new blood vessels. 38 Here, the antiangiogenic effect of compounds was preliminarily evaluated by tube formation assay. As displayed in Figure 5A, GP, GPG, GFB, and Combo groups all showed different degrees of antiangiogenesis effect at a nonlethal concentration (5 μM), while the vascular structure in the CP-treatment group even increased slightly compared with control.…”

Section: Antiangiogenic Effect On Huvec and A2780 Cellsmentioning

confidence: 99%

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Gemfibrozil-Platinum(IV) Precursors for New Enhanced-Starvation and Chemotherapy In Vitro and In Vivo

Song,

Guo,

Ding

et al. 2024

J. Med. Chem.

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A brand-new enhanced starvation is put forward to trigger sensitized chemotherapy: blocking tumor-relation blood vessel formation and accelerating nutrient degradation and efflux. Following this concept, two cisplatin-like gemfibrozil-derived Pt(IV) prodrugs, GP and GPG, are synthesized. GP and GPG had nanomolar IC 50 against A2780 cells and higher selectivity against normal cells than cisplatin. Bioactivity results confirmed that GP and GPG highly accumulated in cells and induced DNA damage, G2-phase arrest, and p53 expression. Besides, they could increase ROS and MDA levels and reduce mitochondrial membrane potential and Bcl-2 expression to promote cell apoptosis. In vivo, GP showed superior antitumor activity in A2780 tumor-bearing mice with no observable tissue damage. Mechanistic studies suggested that highly selective chemotherapy could be due to the new enhanced starvation effect: blocking vasculature formation via inhibiting the CYP2C8/EETs pathway and VEGFR2, NF-κB, and COX-2 expression and cholesterol efflux and degradation acceleration via increasing ABCA1 and PPARα.

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Section: Resultsmentioning

confidence: 99%

Section: Antiangiogenic Effect On Huvec and A2780 Cellsmentioning

confidence: 99%

Gemfibrozil-Platinum(IV) Precursors for New Enhanced-Starvation and Chemotherapy In Vitro and In Vivo

Song,

Guo,

Ding

et al. 2024

J. Med. Chem.

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“…In this study, we screened for prognosis-related biomarkers closely related to immune function, and we also screened for OC-targeting molecular agents based on PI-lncRNAs. Ponatinib is a third-generation tyrosine kinase inhibitor (TKI), which is commonly used clinically in the treatment of adult chronic myelogenous leukemia, Philadelphia chromosome-positive, and acute lymphoblastic leukemia [13] .Axitinib is a VEGFR-TKI that precisely and e ciently inhibits the VEGFR-1, 2 and 3 signalling pathways, which are associated with tumour angiogenesis [14] . Blocking the VEGFR receptor pathway inhibits angiogenesis and thus tumour cell proliferation [15] .…”

Section: Discussionmentioning

confidence: 99%

Mining immune-related LncRNAs in ovarian cancer for prognostic risk modelling and screening of potential target drugs

Dong

Deng

Zhao

et al. 2022

Preprint

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Objective: To screen out ovarian cancer (OC) immune-related LncRNAs, construct a prognostic model for OC and screen out target molecular drugs for OC based on comprehensive bioinformatics analysis. METHODS: Gene expression matrices of 586 OC samples and clinical information of patients were downloaded from the TCGA database, and gene expression matrices of 122 normal OC samples and clinical information of patients were downloaded from the GTEx database, and comprehensive bioinformatics analysis methods were performed, including identification of prognosis-related immune genes (PI-genes), construction of OC prognostic models and their differential gene analysis, survival analysis, risk analysis, independent prognostic analysis and ROC curve mapping, immune correlation analysis and screening of potential target drugs for OC. Results: 540 immune-related lncRNAs (I-lncRNAs) and various clinical traits were analysed for differential gene expression, followed by the identification of 49 PI-genes and the construction of the prognostic model based on 27 candidate PI-genes (CPI-genes) (COLCA1, MINCR, AC068792.1, AL391807.1, AC027020.2, MINCR, AC068792.1, AL391807.1, AL391807.1, AL391807.1, AL391807.1). AC027020.2, MIRLET7BHG, DLGAP1-AS1, DICER1-AS1, AJ011932.1, AC091806.1, FAM27E3, ALDH1L1-AS2, AC008522.1, AC112491.1, AC134312.1, AC010733.1, FRMD6-AS2, DLGAP1-AS2, PSMB8-AS1, AC012645.4, SLX1A-SULT1A3, AC027348.1, FAM157C, AL121845.4, CHRM3-AS2, PKP4-AS1, U62631.1) . The subsequent analysis showed that the prognostic model could predict the survival and risk prognosis of patients in the high and low-risk groups and validated the independent predictive ability and predictive accuracy of the prognostic model, as well as clarified its relationship with immune function. Finally, three potential target drugs for OC (Ponatinib, Luminespib and Axitinib) were identified. CONCLUSION: A prognostic model for OC based on 27 CPI-genes was constructed, and three potential target molecular drugs were screened, which is expected to provide new ideas for prognostic prediction and precise treatment of OC.

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“…Another study using NPs carrying disulfiram was found to attenuate the deterioration of electroretinograms (ERGs) in rats and to restore the decline in retinal function [52]. Additionally, a number of NPs, including poly(lactic-co-glycolic acid) (PLGA) NPs [53,54] and peptide (PENE) NPs [55], can transport medications to the retina through topical application. Some of these NPs may even simultaneously cure anterior and posterior segment eye diseases [56].…”

Section: Nps For Treatment Of Retinal Diseasesmentioning

confidence: 99%

Exploration: Nanoparticles in the Diagnosis and Treatment of Retinal Diseases

Wang

Xie

Chen

et al. 2023

Journal of Nanomaterials

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In recent years, research on nanoparticles (NPs) has brought a new phase in the development of medicine. The term “NPs” refers to nanoscale particles, typically between 10 and 1,000 nm in size, that are within the range of cellular and molecular structures. Compared with traditional ophthalmic drugs, NPs can carry drugs to overcome obstacles, target drug delivery, prolong drug release, reduce drug toxicity, and can be used in gene therapy. After a brief introduction to the classification of NPs, we will focus on the potential applications of different NPs in the diagnosis and treatment of different retinal diseases and introduce innovative methods derived from NPs.

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Penetrating-peptide-mediated non-invasive Axitinib delivery for anti-neovascularisation

Cited by 11 publications

References 26 publications

Gemfibrozil-Platinum(IV) Precursors for New Enhanced-Starvation and Chemotherapy In Vitro and In Vivo

Gemfibrozil-Platinum(IV) Precursors for New Enhanced-Starvation and Chemotherapy In Vitro and In Vivo

Mining immune-related LncRNAs in ovarian cancer for prognostic risk modelling and screening of potential target drugs

Exploration: Nanoparticles in the Diagnosis and Treatment of Retinal Diseases

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