Mining immune-related LncRNAs in ovarian cancer for prognostic risk modelling and screening of potential target drugs

Abstract

Objective: To screen out ovarian cancer (OC) immune-related LncRNAs, construct a prognostic model for OC and screen out target molecular drugs for OC based on comprehensive bioinformatics analysis. METHODS: Gene expression matrices of 586 OC samples and clinical information of patients were downloaded from the TCGA database, and gene expression matrices of 122 normal OC samples and clinical information of patients were downloaded from the GTEx database, and comprehensive bioinformatics analysis methods were performed, including identification of prognosis-related immune genes (PI-genes), construction of OC prognostic models and their differential gene analysis, survival analysis, risk analysis, independent prognostic analysis and ROC curve mapping, immune correlation analysis and screening of potential target drugs for OC. Results: 540 immune-related lncRNAs (I-lncRNAs) and various clinical traits were analysed for differential gene expression, followed by the identification of 49 PI-genes and the construction of the prognostic model based on 27 candidate PI-genes (CPI-genes) (COLCA1, MINCR, AC068792.1, AL391807.1, AC027020.2, MINCR, AC068792.1, AL391807.1, AL391807.1, AL391807.1, AL391807.1). AC027020.2, MIRLET7BHG, DLGAP1-AS1, DICER1-AS1, AJ011932.1, AC091806.1, FAM27E3, ALDH1L1-AS2, AC008522.1, AC112491.1, AC134312.1, AC010733.1, FRMD6-AS2, DLGAP1-AS2, PSMB8-AS1, AC012645.4, SLX1A-SULT1A3, AC027348.1, FAM157C, AL121845.4, CHRM3-AS2, PKP4-AS1, U62631.1) . The subsequent analysis showed that the prognostic model could predict the survival and risk prognosis of patients in the high and low-risk groups and validated the independent predictive ability and predictive accuracy of the prognostic model, as well as clarified its relationship with immune function. Finally, three potential target drugs for OC (Ponatinib, Luminespib and Axitinib) were identified. CONCLUSION: A prognostic model for OC based on 27 CPI-genes was constructed, and three potential target molecular drugs were screened, which is expected to provide new ideas for prognostic prediction and precise treatment of OC.