Pemphigus Involving the Eyes

Bean, Samuel F.

doi:10.1001/archderm.1975.01630230086018

Cited by 38 publications

(15 citation statements)

References 7 publications

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“…[6][7][8][14][15] Typically, conjunctivitis and blepharitis are the main features of the disease, and blisters or erosions on the conjunctiva and the eyelid margin occur but are rare. 9,10,[16][17][18][19] Ocular involvement has been reported as a signal of severe disease and tends to occur several months after the onset of skin or other mucosal lesions. 6 However, there is evidence to suggest that ocular symptoms can precede the onset of skin and mucus membrane lesions, 11,[20][21][22] suggesting that ocular involvement may be underdiagnosed.…”

Section: Discussionmentioning

confidence: 99%

Cicatricial changes in ocular pemphigus

Chirinos-Saldaña

Zuñiga-Gonzalez

Hernández-Camarena

et al. 2014

Eye

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Section: Discussionmentioning

confidence: 99%

Cicatricial changes in ocular pemphigus

Chirinos-Saldaña

Zuñiga-Gonzalez

Hernández-Camarena

et al. 2014

Eye

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“…Nail and eye involvement in pemphigus vulgaris are unusual and there are only a few reports in the literature [1][2][3][4][5]. In most cases, nail lesions are secondary to the presence of bullae on the distal portion of the finger.…”

Section: Discussionmentioning

confidence: 99%

“…Direct immunofluorescence of a nail biopsy can be useful when nail lesions are not associated with skin or mucosal lesions [7]. The most eommon ophthalmological involvement in pemphigus vulgaris Is conjunctival inflammation with vesicles that rapidly rupture leading to erosions [4,5]. Differential diagnosis includes cicatricial pemphigoid of the eyes in which ocular involvement is frequent and severe.…”

Section: Discussionmentioning

confidence: 99%

Unusual presentation of pemphigus vulgaris

Bardazzi

Guerra

Peluso

et al. 1994

Acad Dermatol Venereol

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We report a case of a 50-year-old man who presented with a conjunetiva! erosion and lesions resembling acute paronychia of several fingers. The Tzanck preparation from the conjunctiva showed the presenee of acantholytic eells. Skin biopsy showed suprabasal cleft formation with acantholysis. Direct immunofluorescence revealed intercellular epidermal staining with IgG and C3. Diagnosis of pemphigus vulgaris was therefore confirmed. Nail abnormalities that can be observed in pemphigus vulgaris are discussed.

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“…Although the most frequent mucosal site of involvement has shown to be the oral cavity, ocular surface may also be involved. In 1975, the first report of ocular involvement in PV was released by Bean et al 1 Several case reports and small case series of PV patients with ocular disease have been published since. According to these studies, ocular involvement in PV is considered to be rare, but it is probably underdiagnosed and its frequency appears to be underestimated.…”

Section: Introductionmentioning

confidence: 99%

Ocular involvement in pemphigus vulgaris

Akhyani

Keshtkar-Jafari

Chams‐Davatchi

et al. 2014

The Journal of Dermatology

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Pemphigus vulgaris (PV) is an autoimmune disorder affecting the skin and mucous membranes. Ocular involvement in PV has been reported but its prevalence and clinical characteristics are not well defined. This prospective cross-sectional study of 103 PV patients was designed to determine the prevalence, clinical types and epidemiological trends of ocular involvement in a population of Iranian patients with PV. Ocular involvement was present in 17 (16.5%) patients. Conjunctivitis was the most prevalent type of ocular involvement (9/17, 52.9%), followed by erosion of the palpebral conjunctiva (7/17, 41.2%). Erosion of the bulbar conjunctiva was noted in only one patient (5.9%). The most commonly reported symptoms were eye irritation (76.5%) and redness (76.5%). No significant relation was found between ocular involvement and disease activity (partial remission or relapse). Mucoid discharge was significantly more common in patients with conjunctival erosions as compared to patients with conjunctivitis (P = 0.038). We conclude that ocular involvement is not rare in PV; 16.5% of PV patients develop ocular disease independent of the disease activity and extension. Conjunctivitis is the most common type of involvement, however, palpebral conjunctival erosion is more frequent than previously realized.

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Pemphigus Involving the Eyes

Cited by 38 publications

References 7 publications

Cicatricial changes in ocular pemphigus

Cicatricial changes in ocular pemphigus

Unusual presentation of pemphigus vulgaris

Ocular involvement in pemphigus vulgaris

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