Cicatricial changes in ocular pemphigus

Chirinos-Saldaña, Patricia; Zuñiga-Gonzalez, Isaac; Hernández-Camarena, Julio C.; Navas, Alejandro; Ramirez-Luquín, Tito; Robles-Contreras, Atzín; Jiménez-Martínez, María del Carmen; Ramírez-Miranda, Arturo; Lucio, Víctor Manuel Bautista-de; Graue-Hernandez, E O

doi:10.1038/eye.2014.3

Cited by 20 publications

(14 citation statements)

References 41 publications

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“…K Pemphigus vulgaris may rarely present in the conjunctiva as conjunctivitis in addition to conjunctival scarring, and conjunctival DIF has shown the characteristic epithelial intercellular fluorescence to IgG and/or complement 14 shown in Figure 5, that is typically found in the skin at the dermoepidermal junction (basement membrane zone) in PV. 19…”

Section: Interpretation Of Dif Resultsmentioning

confidence: 99%

“…Pemphigus diseases in which conjunctival disease is unreported: pemphigus gestationis, pemphigus foliaceous (may involve lid skin but not the conjunctiva) 135 and IgA pemphigus Pemphigus vulgaris 14,136 Conjunctivitis occurs but scarring is rare. However, several cases have presented in the eye accompanied by severe scarring and corneal perforation 14 Paraneoplastic pemphigus 13,136 Conjunctivitis occurs.…”

Section: Pemphigus Diseases (Intra-epithelial Immunobullous Diseases)mentioning

confidence: 99%

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The 2016 Bowman Lecture Conjunctival curses: scarring conjunctivitis 30 years on

Dart

2017

Eye

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This review is in two sections. The first section summarises 35 conditions, both common and infrequent, causing cicatrising conjunctivitis. Guidelines for making a diagnosis are given together with the use of diagnostic tests, including direct and indirect immunofluorescence, and their interpretation. The second section evaluates our knowledge of ocular mucous membrane pemphigoid, which is the commonest cause of cicatrizing conjunctivitis in most developed countries. The clinical characteristics, demographics, and clinical signs of the disease are described. This is followed by a review and re-evaluation of the pathogenesis of conjunctival inflammation in mucous membrane pemphigoid (MMP), resulting in a revised hypothesis of the autoimmune mechanisms causing inflammation in ocular MMP. The relationship between inflammation and scarring in MMP conjunctiva is described. Recent research, describing the role of aldehyde dehydrogenase (ALDH) and retinoic acid (RA) in both the initiation and perpetuation of profibrotic activity in MMP conjunctival fibroblasts is summarised and the potential for antifibrotic therapy, using ALDH inhibition, is discussed. The importance of the management of the ocular surface in MMP is briefly summarised. This is followed with the rationale for the use of systemic immunomodulatory therapy, currently the standard of care for patients with active ocular MMP. The evidence for the use of these drugs is summarised and guidelines given for their use. Finally, the areas for research and innovation in the next decade are reviewed including the need for better diagnostics, markers of disease activity, and the potential for biological and topical therapies for both inflammation and scarring.

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Section: Interpretation Of Dif Resultsmentioning

confidence: 99%

Section: Pemphigus Diseases (Intra-epithelial Immunobullous Diseases)mentioning

confidence: 99%

The 2016 Bowman Lecture Conjunctival curses: scarring conjunctivitis 30 years on

Dart

2017

Eye

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“…2B). 1,25,28,[30][31][32] Histological findings on conjunctival tissues are not specific. The typical acantholysis described for skin lesions has been rarely observed and is confined to the suprabasal epithelium of the conjunctiva.…”

Section: Ocular Involvementmentioning

confidence: 90%

Pemphigus

Chirinos-Saldaña

Navas

Ramírez-Miranda

et al. 2016

Eye &Amp; Contact Lens: Science &Amp; Clinical Practice

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“…Persistent inflammation and erosion of the eyelids may affect the anatomy of the lid margin and the quality of the tear film and cause severe dryness, leading to poor vision quality [6,7]. Atypical features are also reported, including cicatricial changes on both bulbar and tarsal conjunctivae, cobblestone-like conjunctival papillae, and trichiasis resembling mucous membrane pemphigoid [8,9]. No case of scleromalacia perforans associated with pemphigus has been reported.…”

Section: Discussionmentioning

confidence: 99%

Scleromalacia Perforans Secondary to a Pemphigus

Ha¹

2019

MJCCS

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Scleromalacia perforans is a rare form of anterior scleritis represented by progressive thinning of the sclera. It is most often associated with rheumatoid arthritis,and sometimes seen in inflammatory systemic disease. Rarely scleromalacia has been described in porphyria and herpes zoster. We are reporting the case of 62 year old man who was followed for pemphigus vulgaris and who developed scleromalacia perforans of the eye. The association between pemphigus and SP has never been described before so this report suggests adding SP to rare but possible complications of pemphigus and hilights the importance of multidisciplinary care.

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Cicatricial changes in ocular pemphigus

Cited by 20 publications

References 41 publications

The 2016 Bowman Lecture Conjunctival curses: scarring conjunctivitis 30 years on

The 2016 Bowman Lecture Conjunctival curses: scarring conjunctivitis 30 years on

Pemphigus

Scleromalacia Perforans Secondary to a Pemphigus

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