PEMPHIGUS: An Acronym for a Disease With Multiple Etiologies

Brenner, Sarah; Mashiah, Jacob; Tamir, Einat; Goldberg, Ilan; Wohl, Yonit

doi:10.1111/j.1540-9740.2003.02040.x

Cited by 31 publications

(28 citation statements)

References 52 publications

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“…17 Felliciani ve arkadaşları tannik asitin invitro akantolizi indüklediğini göste-rerek, tannik asit içeren gıdaların pemfigusu tetikleyebileceğini öne sürm-üştür. 18 Çay, kahve, acı ve baharatlı gıdalar, tiyol, izotiosiyanat, tannik asit ve sülfür içermektedir. ancak hastalarımızda bu gıdaların kontrol grubuna göre daha fazla tüketildiğine ait bir veri elde edilmemiştir.…”

Section: Discussionunclassified

Pemfigusta Risk Faktörleri

Demirci¹,

Mansur²,

Aydıngöz³

2011

TURKDERM

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ÖzetAmaç: Pemfigusun ortaya çıkmasında ve hastalığın seyrinde bazı dış faktörlerin etkili olduğu üzerinde durulmaktadır. Bu araştırma-da pemfigus tanısı ile takip ettiğimiz hastalarda hastalığın etyolojisinde rol oynayabilecek faktörlerin araştırılması amaçlanmıştır. Gereç ve yöntem: Kliniğimizde 1998-2004 yılları arasında histopatolojik ve direkt immunofloresan incelemeler ile pemfigus tanı-sı konan 15'i erkek, 27'si kadın toplam 42 hasta, demografik özellikler, meslek grubu, eğitim düzeyi, hastalığın ortaya çıkmadan önceki süreçte geçirilmiş stresli yaşam olayları, gebelik sayısı, diyet, sigara ve alkol alışkanlığı gibi etkenler açısından sorgulanarak benzer sosyoekonomik düzeye sahip, aynı yaş ve cinsiyetteki bir kontrol grubuyla karşılaştırıldı. Bulgular: Hayvancılık ve tarım ile uğraşmanın, gebelik sayısının fazla oluşunun, sigara içmemenin ve psikolojik stresin pemfiguslu hastalarda kontrol grubuna göre istatistiksel olarak anlamlı oranda yüksek bulunduğu saptandı. Sum maryBackground and Design: There have been reports suggesting the involvement of environmental factors in the disease process of pemphigus. In this study, we aimed to find out the risk factors which could play role in the etiopathogenesis in our pemphigus patients. Material and method: A total of 42 patients (15 male and 27 female) who were diagnosed as pemphigus with histopathological and direct immunoflurosence examinations in our clinic between the years 1998-2004, were interviewed for assessment of regarding with the subjects of the demographic properties, occupational groups, educational level, the number of pregnancies, stressfull life events, diet habits, smoking and alcohol consumption before the onset of the disease and the results were compared to 42 age and gender-matched controls with similar socioeconomic circumstances. Results: Working in agriculture and livestock, multi-parity, absence of smoking and stressfull life events were found to be statistically significant in pemphigus patients than in controls. Conclusion: Working in agriculture and livestock, multi-parity, absence of smoking and stressfull life events were assumed to play role in the etiopathogenesis and course of pemphigus. (Turk derm 2011; 45: 140-5)

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Section: Discussionunclassified

Pemfigusta Risk Faktörleri

Demirci¹,

Mansur²,

Aydıngöz³

2011

TURKDERM

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“…Çalışmamızda yaş ortalaması, Türkiye'nin Batı bölgesi ve Güney Afrika'daki çalışmalarla benzer şekilde 47,6 yıldı. Son çalışmalarda, hastalığın genç yaşta (<40 yaş) başlaması pemfigus için kötü prognoz işareti olarak değerlendirmektedir 16 . Çalışmamızda en genç hasta 7 yaşında ve en yaşlı hasta 95 yaşındaydı.…”

Section: Bulgularunclassified

A retrospective study of 102 patients with pemphigus

Metin¹,

Kızılyel²,

Elmas³

et al. 2015

TURKDERM

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Background and Design:Pemphigus is a severe and life-threatening chronic autoimmune mucocutaneous blistering disease. The aim of this study was to evaluate and analyze the course, prognostic factors and epidemiological, clinical and therapeutic features of pemphigus in patients followed between 2004 and 2013. Materials and Methods: We performed a 10-year retrospective study of patients diagnosed with pemphigus in Erzurum. The parameters that were evaluated include age, sex, diagnostic methods, duration of hospitalizations, distribution of lesions, duration of treatment and therapeutic doses. Results:The results showed that the estimated annual incidence rate was 1.31 cases per 100.000 person-years. The male to female ratio was 1: 0.81. The mean age at onset of the disease was 48 years (range: 7-95 years). Thirty-six patients had only skin lesions and sixty-six cases had both skin and oral mucosal lesions. The majority of the patients (58.8%) with pemphigus were treated with middle or high-dose corticosteroids (40-160 mg/day). Conclusions: Pemphigus vulgaris is the most common clinical subtype in Erzurum and the mean age of the disease onset in the present study was found to be a decade earlier than in other parts of the world. The patients with both oral mucosa and skin involvement required higher corticosteroid doses and longer hospitalization time when compared to the patients with oral mucosa involvement alone. (Turkderm 2015; 49: 125-8)

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“…Pemeriksaan klinis dilakukan dengan teliti dan cermat untuk membedakan dengan penyakit vesikobulosa lain seperti MMP. 5,7,11 Pada MMP, 90% kasus memiliki manifestasi oral berupa deskuamasi gingiva. Hal ini berbeda dengan PV yang manifestasi oralnya terutama bula dan riwayat penyakit yang kronis, sehingga membutuhkan perawatan yang lebih intensif.…”

Section: Pembahasanunclassified

Management of Suspected Pemphigus Vulgaris in Elderly Patient with Chronic Diseases

Prihanti

Jusri²

2013

J Dent Indones

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Pemphigus vulgaris (PV) is a group of vesicobullous disease that affects skin and mucous membranes. PV is associated with autoimmune diseases, characterized by binding of IgG autoantibodies to desmoglein 3 on desmosome. The lesion of PV is a thin-walled bulla arising on the normal skin or mucosa. The bulla of oral mucous are more fragile and rapidly break down, forming irreguler ulcers. There are several factors that can trigger PV including genetic factors, age, drugs and food. The purpose of this paper was to report the treatment of suspected pemphigus vulgaris in elderly patient with history of chronic diseases. A 75- year-old woman with 2 months history of bulla formation on skin and about a month history of persistent oral ulceration. Ulcers were covered hypertension, diabetes mellitus and hepatitis. On routine complete blood count was found thrombocytopenia.distinguished from other vesicobullous disease. Systemic corticosteroid therapy was given concurrently with hepato-protector, mouthwash, supportive therapy and topical lip cream. Bulla on skin and persistent erosive ulcers of PV and thus require more intensive and comprehensive treatment. ABSTRAK(PV) adalah kelompok penyakit vesikulobulosa yang dapat mengenai kulit dan membran mukosa. PV merupakan penyakit autoimun dengan karakteristik adanya ikatan antara autoantibodi IgG dengan desmoglein 3 pada desmosom. Lesi PV merupakan bula berdinding tipis yang timbul pada kulit dan mukosa yang terlihat normal. Bula pada mukosa oral sangat mudah pecah dan membentuk ulser. Terdapat beberapa faktor yang dapat mencetuskan PV meliputi faktor genetik, usia, pemakaian obat-obatan dan makanan. Tulisan ini melaporkan penatalaksanaan kasus yang diduga adalah PV yang terjadi pada lansia dengan riwayat penyakit kronis. Kasus adalah wanita berusia 75 tahun dengan riwayat adanya lesi bula di kulit sejak eritema pada mukosa labial, bukal, dan gingiva. Terdapat riwayat hipertensi, diabetes mellitus, hepatitis, dan trombositopenia. Diagnosis PV ditegakkan berdasarkan keluhan subjekif dan klinis yang dapat dibedakan dengan penyakit vesikobulosa yang lain. Kortikosteroid sistemik diberikan bersama hepato protektor, obat kumur, terapi suportif, dan krim bibir. Bula pada kulit dan ulserasi yang menetap pada mukosa oral adalah manifestasi PV. Pada pasien lansia ini keadaan sistemiknya membutuhkan penatalaksanaan yang lebih intensif dan komprehensif.Key words: autoimmune disease, chronic disease, elderly patient, pemphigus vulgaris PENDAHULUAN Pemphigus vulgaris (PV) yang merupakan kelompok penyakit vesikobulosa, menyerang kulit dan membran mukosa. Lesi pada mukosa rongga mulut ditemukan pada sekitar 80-90% pasien PV dan 60% kasus mempunyai tanda awal PV pada mukosa rongga mulut. [1][2][3][4] Etiologi PV berkaitan dengan reaksi autoimun yaitu terjadinya ikatan antara imunoglobulin G (IgG) autoantibodi dengan protein desmosom sel keratinosit di bawah permukaan stratum spinosum yaitu desmoglein (Dsg) 1 dan 3 glikoprotein transmembran.5 Antibodi PV bereaksi hanya pada antigen per...

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PEMPHIGUS: An Acronym for a Disease With Multiple Etiologies

Cited by 31 publications

References 52 publications

Pemfigusta Risk Faktörleri

Pemfigusta Risk Faktörleri

A retrospective study of 102 patients with pemphigus

Management of Suspected Pemphigus Vulgaris in Elderly Patient with Chronic Diseases

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