Pemfigusta Risk Faktörleri

Demirci, Gülşen Tükenmez; Mansur, Ayşe Tülin; Aydıngöz, İkbal Esen

doi:10.4274/turkderm.27676

Cited by 3 publications

(1 citation statement)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…They reported that IVIG stopped the formation of bullous and epidermal detachment [7]. In addition, Tukenmez et al [8] reported IVIG therapy with positive results in two cases with TEN. In a multicenter study, Prins et al found that in the early period high-dose IVIG infusion was safe, well-tolerated and an effective treatment modality in cases with TEN [9].…”

Section: Discussionmentioning

confidence: 99%

Successful management of a patient with toxic epidermal necrolysis by high dose intravenous immunoglobulin

Güneş¹,

Yolbaş

Kelekçi³

et al. 2013

J Clin Exp Invest

View full text Add to dashboard Cite

Toksik epidermal nekrolizis (TEN) sıklıkla ilaç kullanımı sonucu gelişen, akut başlangıçlı, çok hızlı ilerleyen, epidermis nekrozu ile karakterize bir hastalıktır. Şiddetli seyreden olgularda mortalite oranı %20-60 arasında değişir. Kesin tedavisi olmamasına rağmen intravenöz immünglobulin (İVİG) tedavisinin etkili olduğunu belirten yayınlar mevcuttur. Bu çalışmada; ibuprofen, metronidazol, klaritromisin ve prokain penisilin kullandıktan üç gün sonra deri döküntüleri başlayan ve %50 oranında ikinci derecede yanık düzeyinde lezyonlar ile TEN tablosu gelişen 9 yaşında erkek hasta sunulmuştur. Hastaya verilen yüksek doz İVİG tedavisi ile düzelme sağlandı. Bu olgu TEN tedavisinde etkinliği tartışmalı olan İVİG tedavisine olumlu yanıt alınabileceğine bir örnektir.

show abstract

Section: Discussionmentioning

confidence: 99%

Successful management of a patient with toxic epidermal necrolysis by high dose intravenous immunoglobulin

Güneş¹,

Yolbaş

Kelekçi³

et al. 2013

J Clin Exp Invest

View full text Add to dashboard Cite

show abstract

Epidemiology of pemphigus in the western region of Turkey: retrospective analysis of 87 patients

Bozdağ

Bilgin²

2012

Cutaneous and Ocular Toxicology

View full text Add to dashboard Cite

Pemphigus vulgaris (PV) is the most common clinical subtype in the western part of Turkey. The disease is more frequent in the fifth decade of life and has a female predominance in our region. The patients with both oral mucosa and skin involvement need higher corticosteroid dose, more time to control the disease activity and longer hospitalization time when compared with the patients with oral mucosa involvement alone.

show abstract

Possible triggering factors and comorbidities in newlydiagnosed autoimmune bullous diseases

Akarsu¹,

Özbağçıvan²,

Dolaş³

et al. 2017

Turk J Med Sci

View full text Add to dashboard Cite

IntroductionAutoimmune bullous diseases (ABDs) are a group of rarely seen organ-specific diseases caused by pathogenic autoantibodies against target antigens that function in the intercellular or the mesenchymal/dermal junction of the epidermis. Clinically, ABDs display quite a wide spectrum of vesicle or bulla formations on the skin and/or the mucous membranes. ABDs are classified mainly as intraepidermal bullous disease (pemphigus) and subepidermal bullous diseases (pemphigoid, dermatitis herpetiformis, and acquired epidermolysis bullosa), according to the depth of blister formation on the skin and types of autoantibodies against structural proteins (1). Generally, pemphigus vulgaris (PV) and bullous pemphigoid (BP) form the greater portion of ABDs, and therefore they are the most frequently known ABDs (1,2).The demographic, clinical, and etiological characteristics of ABDs and the incidence of subgroups vary according to geographic regions (1,2). In Turkey, despite the absence of national data, the first annual incidence estimations in the Mediterranean and Aegean regions of the country were reported as 2.4 and 1.8 per million by Uzun et al. and Bozdag and Bilgin, respectively (3,4). However, it was observed that these limited numbers of published data were of retrospective nature and focused on pemphigus only (3-5). Nevertheless, one of the two recently published retrospective studies from Turkey covered pemphigus with other ABDs, and the other included patients with hereditary bullous diseases and other ABDs (6,7). In this study we aimed to evaluate demographic data, clinical characteristics, related triggering factors, and comorbidities of newly diagnosed patients with ABDs at our clinic.Background/aim: The distribution and the demographic, etiological, and clinical features of autoimmune bullous diseases (ABDs) vary according to geographic regions of the world. The limited number of reported studies in Turkey are mostly retrospective and generally include only pemphigus. The aim of our study was to evaluate the demographic data, clinical features, associated triggering factors, and comorbidities in patients newly diagnosed with ABDs. Materials and methods:In this descriptive and prospective study, the demographic data, inhabited regions, smoking and drinking habits, presence of comorbidities, and specific and general potential triggering factors of ABDs considered by the patients were examined. Furthermore, the distribution of lesions and autoimmune bullous skin disorder intensity scores were recorded.Results: Of the total 59 ABD patients, 26 (44.1%) were diagnosed with pemphigus, 25 (42.4%) were diagnosed with pemphigoid, and 8 (13.5%) were diagnosed with dermatitis herpetiformis. Although there were some differences between the subgroups of ABDs, the onset of the disease was associated with a triggering factor (stress, foods, physical trauma, chemical agents, ultraviolet rays, medications, infections, malignancies, and pregnancy, in a decreasing frequency) in 96.6% of the patients. Autoimmune diseases, ...

show abstract

Pemfigusta Risk Faktörleri

Cited by 3 publications

References 20 publications

Successful management of a patient with toxic epidermal necrolysis by high dose intravenous immunoglobulin

Successful management of a patient with toxic epidermal necrolysis by high dose intravenous immunoglobulin

Epidemiology of pemphigus in the western region of Turkey: retrospective analysis of 87 patients

Possible triggering factors and comorbidities in newlydiagnosed autoimmune bullous diseases

Contact Info

Product

Resources

About