Pemphigoid Gestationis in a Third Trimester Pregnancy

Şentürk, Senem; Dilek, Nursel; Tekın, Yeşim Bayoğlu; Çolak, Sabri; Gündoğdu, Betül; Güven, Emine Seda Güvendağ

doi:10.1155/2014/127628

Cited by 5 publications

(7 citation statements)

References 15 publications

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“…PG usually begins with intense itchy erythematous urticarial papules and plaques surrounding the umbilicus. The lesions quickly spread to the abdomen, back, chest and extremities, mucosal surfaces, palms, and soles of the feet with habitual respect of the face [11,12]. In our series we noticed the involvement of the face in two cases.…”

Section: Discussionmentioning

confidence: 46%

Pemphigoid gestationis: A Moroccan study

Chakiri¹,

Salim²,

Inani³

et al. 2017

Our Dermatol Online

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Section: Discussionmentioning

confidence: 46%

Pemphigoid gestationis: A Moroccan study

Chakiri¹,

Salim²,

Inani³

et al. 2017

Our Dermatol Online

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“…Then the classical complement pathway activates, attracting eosinophils and lymphocytes. An inflammatory infiltrate develops in the basement membrane zone and cellular mediators are released resulting in the dermal-epidermal junction damage and blisters formation (8,11,12) . Antibodies against BP 180 have also been identified in other diseases such as bullous pemphigoid and linear IgA disease (11) .…”

Section: Pathogenesismentioning

confidence: 99%

“…Circulating autoantibodies may be found by indirect immunofluorescence, in 20-60% of cases. By using complement fixation technique IgG antibodies are detected in 90% of cases (5,8) .…”

Section: Diagnosismentioning

confidence: 99%

“…These antibodies are not found in PUPPP, thus NC16A ELISA may be useful in the differential diagnosis. NC16A ELISA has a high sensitivity and specificity (8,11,12) . Furthermore, ELISA is faster and less costly than immunoblotting (28)(29)(30) .…”

Section: Diagnosismentioning

confidence: 99%

“…PG is more common in caucasian people. This could be explained by the fact that HLA DR3 and HLA DR4 are found in a greater proportion in these individuals (6,8) . Furthermore, PG was originally termed herpes gestationis by John Laws Milton, in 1872, given the herpetiform appearance of the lesions.…”

Section: Introductionmentioning

confidence: 99%

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Pemphigoid gestationis – a rare disease encountered in pregnancy

Tampa¹

2015

Gineco.eu

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Pemphigoid gestationis is a specific autoimmune disease of pregnancy. The onset occurs most commonly in the second or third trimester of pregnancy. Initially, the clinical picture is difficult to distinguish from polymorphic urticarial papules and plaques of pregnancy, urticarial plaques being present in both. Afterwards, the lesions form tense vesicles and bullae on an erythematous base. Direct immunofluorescence reveals C3 linear deposits, with or without IgG deposits along the basement membrane zone. Circulating antibodies are directed primarily against type XVII collagen (BP 180). The main fetal risks are preterm birth and fetal growth restriction. The treatment may be harmful for the fetus. Mild and moderate topical corticosteroids should be used. Systemic corticotherapy, azathioprine or dapsone should be administered in severe cases. Disease activity and treatment efficacy may be evaluated by measuring antibodies titer.

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Diagnosis, fetal risk and treatment of pemphigoid gestationis in pregnancy: A case report

Jiao¹,

Ruan²,

Liu³

et al. 2021

WJCC

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BACKGROUND Pemphigoid gestationis (PG) is a rare autoimmune blistering disease that usually presents in the second or third trimester, with an incidence of 1 per 50000 pregnancies. PG tends to recur with an earlier onset and a more severe course in subsequent pregnancies. Skin biopsy markers can be confirmed by direct immunofluorescence staining. CASE SUMMARY Our patient was diagnosed with PG at 8 mo of gestation with fresh bullous lesion marks on the abdomen and limbs. Termination of the pregnancy was performed by cesarean section at 37 + 4 wk of gestation. The patient delivered an infant weighing 3620 gm. The infant had urticaria-like and vesicular skin lesions and was diagnosed with PG. The patient was discharged on prednisolone and in a satisfactory condition. The infant was discharged after anti-inflammatory therapy for one week. CONCLUSION PG is a rarely reported disease, and 10% of newborns develop mild clinical symptoms consisting of urticaria-like or vesicular skin lesions. We intend to remind clinicians to consider this condition when a patient presents with such lesions so that treatment can be started early and neonatal morbidity can be taken into account.

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Pemphigoid Gestationis in a Third Trimester Pregnancy

Cited by 5 publications

References 15 publications

Pemphigoid gestationis: A Moroccan study

Pemphigoid gestationis: A Moroccan study

Pemphigoid gestationis – a rare disease encountered in pregnancy

Diagnosis, fetal risk and treatment of pemphigoid gestationis in pregnancy: A case report

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