Pemphigoid gestationis: A Moroccan study

Chakiri, Radia; Salim, Gallouj; Inani, K.; Zahra, Mernissi Fatima; Harmouch, Taoufiq

doi:10.7241/ourd.20172.36

Cited by 3 publications

(5 citation statements)

References 22 publications

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“…Gestational pemphigoid can recur in subsequent pregnancies with more severe lesions during menstruation and ovulation [ 9 ]. However, in this case, this was the first time this patient presented with this condition in her third pregnancy that was easily controlled by treatment and did not reoccur.…”

Section: Discussionmentioning

confidence: 99%

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Gestational Pemphigoid Presenting in the Second Trimester of Pregnancy: A Rare Finding

Ghafoor¹,

Hanif²,

Ullah³

et al. 2022

Cureus

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Gestational pemphigoid (GP) is a rare autoimmune blistering disorder, occurring in 1 in 60,000 pregnancies. It occurs in the second or third trimester of pregnancy and is characterized by autoantibodies against hemidesmosomal proteins. A variety of dermatological conditions are associated with pregnancy; among these skin diseases, gestational pemphigoid is very rare. The purpose of this report is to highlight the specific findings of this rare disease to enable clinicians to take prompt intervention in treating this condition. A 23-year-old multigravida, with no known comorbidities, presented to us at 18 weeks of gestation with complaints of intensely pruritic tense blisters all over the body, sparing the scalp, palms, and soles. The diagnosis was confirmed by skin biopsy for histopathology, after which the patient was started on prednisolone, which was then gradually tapered to an appropriate maintenance dose and then discontinued as the patient did not report any new lesions after delivery. Gestational pemphigoid can recur in subsequent pregnancies with more severe lesions. However, this was the first time the patient presented with this condition in her third pregnancy. Proper management of this disease requires close monitoring and appropriate drug therapy to reduce maternal and neonatal morbidity.

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Section: Discussionmentioning

confidence: 99%

“…In terms of pregnancy outcomes, there have been reports of preterm delivery and fetal growth restriction as associated risk factors for GP [ 9 , 10 ]. About 10% of infants have also developed mild skin lesions due to placental transfer of antibodies that heal after a few days, but overall the outcomes are good.…”

Section: Discussionmentioning

confidence: 99%

Gestational Pemphigoid Presenting in the Second Trimester of Pregnancy: A Rare Finding

Ghafoor¹,

Hanif²,

Ullah³

et al. 2022

Cureus

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“…PG, also known as herpes gestationis, is a rare self-limited pregnancy-associated bullous autoimmune disease. Although it usually occurs in the late third trimester, it may develop at any time during pregnancy or in the immediate postpartum [8,[35][36][37][38][39]. The first cases of PG complicating egg donation pregnancy have recently been reported [40,41].…”

Section: Definition and Epidemiologymentioning

confidence: 99%

Pruritus in Pregnancy

et al. 2022

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Pruritus in pregnancy is a common and burdensome symptom that may be a first sign of a pregnancy-specific pruritic disease (atopic eruption of pregnancy, polymorphic eruption of pregnancy, pemphigoid gestationis, and intrahepatic cholestasis in pregnancy) or a dermatosis coinciding with pregnancy by chance. Despite its high prevalence, pruritus is often underrated by physicians, and data regarding the safety profiles of drugs for pruritus are very limited. In this review, we illustrate the epidemiology, possible pathophysiology, clinical characteristics, and diagnostic workup of various pregnancy-related diseases and discuss antipruritic treatments. The prevalence of pruritus in pregnancy demonstrates the importance of symptom recognition and the need for an holistic approach, taking into account both the potential benefits for the patient and the potential risks to the fetus.

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“… 5 – 8 The incidence is estimated to be approximately 1 in 60,000 pregnancies. 9 , 10 The disease shows a worldwide distribution 2 , 5 , 6 , 8 , 11 , 12 and no differences in ethnicity. 13 The median age of affected women varies between 17 and 41 years, with a median age of onset around 26–32 years.…”

Section: Epidemiology and Risk Factorsmentioning

confidence: 99%

“…PG mainly affects multiparous women in their second or third trimester of pregnancy, but onset in the first trimester or postpartum period is also reported. 2 , 11 , 12 , 14 , 16 – 19 In a case series from the UK of women with PG including 117 pregnancies, the time of onset of PG ranged from 5 weeks of gestation to 35 days postpartum. Of the 117 pregnancies, 21 (17.9%) presented in the first trimester, 40 (34.2%) presented in the second trimester, and 40 (14.2%) presented in the third trimester, whereas in 16 (13.7%) the eruption began postpartum.…”

Section: Epidemiology and Risk Factorsmentioning

confidence: 99%

Pemphigoid gestationis: current perspectives

Sävervall

Sand

Thomsen

2017

CCID

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Many skin diseases can occur in pregnant women. However, a few pruritic dermatological conditions are unique to pregnancy, including pemphigoid gestationis (PG). As PG is associated with severe morbidity for pregnant women and carries fetal risks, it is important for the clinician to quickly recognize this disease and refer it for dermatological evaluation and treatment. Herein, we review the pathogenesis, clinical characteristics, and management of PG.

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Pemphigoid gestationis: A Moroccan study

Cited by 3 publications

References 22 publications

Gestational Pemphigoid Presenting in the Second Trimester of Pregnancy: A Rare Finding

Gestational Pemphigoid Presenting in the Second Trimester of Pregnancy: A Rare Finding

Pruritus in Pregnancy

Pemphigoid gestationis: current perspectives

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