Pellagra, Beriberi and Riboflavin Deficiency in Human Beings

Spies, Tom D.; Vilter, Richard W.; Ashe, William F.

doi:10.1001/jama.1939.72800350007012

Cited by 66 publications

(4 citation statements)

References 16 publications

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“…While lip fissuring alone has been described in cases of riboflavine deficiency (Spies, Vilter, and Ashe, 1939), it should be emphasized that the patients reported here were not only receiving adequate amounts of this vitamin but failed to respond to additional large supplements.…”

Section: Discussionmentioning

confidence: 60%

A Deficiency State Arising in Infants on Synthetic Foods

Tp¹,

Km²,

Be³

1965

Archives of Disease in Childhood

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Section: Discussionmentioning

confidence: 60%

A Deficiency State Arising in Infants on Synthetic Foods

Tp¹,

Km²,

Be³

1965

Archives of Disease in Childhood

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“…Corneal vascularization has been described in the riboflavin-deficient rat (33), in the galactoflavin-treated rat (34), and in endemic deficiencies in man (35)(36)(37)(38), which are usually complex deficiencies. It lias not been produced experimentally in man.…”

Section: Discussionmentioning

confidence: 99%

The Rapid Induction of Human Riboflavin Deficiency with Galactoflavin *

Lane¹,

Alfrey²,

Mengel³

et al. 1964

J. Clin. Invest.

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Signs of riboflavin deficiency require many months to develop in patients placed on riboflavinrestricted diets (1-6). The demonstrations that riboflavin deficiency induced by dietary restriction or riboflavin antagonists resulted in regression of rodent tumors (7-13) prompted several efforts in this laboratory to produce riboflavin deficiency in patients with neoplastic disease (14, 15). Riboflavin antagonists were used in these studies with the objective of producing the deficiency state rapidly, since a regimen requiring many months of dietary restriction would not lend itself to therapeutic evaluation in patients with metastatic cancer. These earlier investigations did not result in the production of clinical evidences of riboflavin deficiency or in objective demonstrations of tumor regression. The administered riboflavin antagonists, selected on the basis of their effectiveness in rats, were shown to be metabolized differently in man. The most active of these agents against rat tumors, 6,7-dimethyl-9-(2'-acetoxyethyl) -isoalloxazine, was rapidly and almost completely hydrolyzed in man, although a significant amount of the absorbed drug was excreted unchanged by rats. With the objective of producing human riboflavin deficiency, an analog was sought that would be an effective riboflavin antagonist in rodents and would be metabolized similarly in rodents and in man.The present paper describes studies with 1O-Ddulcityl -7,8-dimethyl-isoalloxazine, galactoflavin,

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“…Prolonged severe deficiency of either vitamin A or riboflavin are reported to result, in both man and animals, in corneal opacities (Pillat, 1929a, b ;Lowenthal, 1933;Day, Darby & Langston, 1937;Bessey & Wolbach, 1939;Spies, 1939;Spies, Vilter & Ashe, '949 1939;Sydenstricker, Sebrell, Cleckley & Kruse, 1940;MCtivier, 1941). These opacities due to nutritional causes are always anteriorly situated and usually superficial, in contrast to syphilitic keratitis, and are reported to respond to therapy with whichever vitamin is deficient.…”

Section: Corneal Opacitiesmentioning

confidence: 99%

Nutrition of Nigerian Peasant Farmers, with Special Reference to the Effects of Vitamin A and Riboflavin Deficiency

Nicol

1949

Br J Nutr

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Pellagra, Beriberi and Riboflavin Deficiency in Human Beings

Cited by 66 publications

References 16 publications

A Deficiency State Arising in Infants on Synthetic Foods

A Deficiency State Arising in Infants on Synthetic Foods

The Rapid Induction of Human Riboflavin Deficiency with Galactoflavin *

Nutrition of Nigerian Peasant Farmers, with Special Reference to the Effects of Vitamin A and Riboflavin Deficiency

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