A Deficiency State Arising in Infants on Synthetic Foods

Tp, Mann; Km, Wilson; Be, Clayton

doi:10.1136/adc.40.212.364

“…Deficiencies of riboflavine and pantothenic acid are known to cause skin rashes; but since even the smaller amount of riboflavine which was given would have been adequate for the patient (Jackson, Hanna, and Flynn, 1962), the lack of pantothenic acid must have been responsible for the rash. This is supported by the experimental studies on rats of Mann et al (1965) which strongly suggested that pantothenic acid was necessary to clear the skin manifestations. Furthermore, in a patient with a similar deficiency rash (Lorber, 1965), this improved with the addition of Ketovite tablets (containing Ca pantothenate) without choline.…”

supporting

confidence: 66%

Glucose-Galactose Malabsorption

2009

Nutrition Reviews

0

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Primary disaccharidase deficiency is a well-known cause of diarrhoea in infancy. The offending disaccharide appears in the stool after ingestion due to the absence in the intestinal mucosa of the appropriate splitting enzyme. A much rarer cause of diarrhoea in this period is a failure of absorption of the monosaccharides, glucose and galactose, in the presence of histologically normal mucosa and full disaccharidase activity. The clinical and biochemical picture of this newly-described entity is characteristic. Watery diarrhoea, with glucose and/or galactose in the stools, develops within three days of milk feeding and continues as long as the feeds contain these monosaccharides or any carbohydrate composed ofthem. Carbohydrate tolerance studies show that the patient can absorb fructose well, and diarrhoea stops with subsequent thriving when this monosaccharide is substituted for other carbohydrates in the feeds.A total of 13 cases has so far been reported from various parts of the world (Laplane, Polonovski,

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“…Deficiencies of riboflavine and pantothenic acid are known to cause skin rashes; but since even the smaller amount of riboflavine which was given would have been adequate for the patient (Jackson, Hanna, and Flynn, 1962), the lack of pantothenic acid must have been responsible for the rash. This is supported by the experimental studies on rats of Mann et al (1965) which strongly suggested that pantothenic acid was necessary to clear the skin manifestations. Furthermore, in a patient with a similar deficiency rash (Lorber, 1965) …”

supporting

confidence: 66%

Glucose-Galactose Malabsorption

1966

N Engl J Med

1

0

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Primary disaccharidase deficiency is a well-known cause of diarrhoea in infancy. The offending disaccharide appears in the stool after ingestion due to the absence in the intestinal mucosa of the appropriate splitting enzyme. A much rarer cause of diarrhoea in this period is a failure of absorption of the monosaccharides, glucose and galactose, in the presence of histologically normal mucosa and full disaccharidase activity. The clinical and biochemical picture of this newly-described entity is characteristic. Watery diarrhoea, with glucose and/or galactose in the stools, develops within three days of milk feeding and continues as long as the feeds contain these monosaccharides or any carbohydrate composed ofthem. Carbohydrate tolerance studies show that the patient can absorb fructose well, and diarrhoea stops with subsequent thriving when this monosaccharide is substituted for other carbohydrates in the feeds.A total of 13 cases has so far been reported from various parts of the world (Laplane, Polonovski,

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“…These considerations are still being overlooked in other clinical situations calling for artificial diets. 32 33 The pocket book by Wood34 contains valuable practical information on this and other aspects of infant nutrition. Other artificial supplements that may also find a place in treating certain diseases include low molecular weight glucose polymers and medium-chain triglycerides (see Table III).…”

Section: Sources Of Informationmentioning

confidence: 99%