PEGylation of poly(hydroxybutyrate) into multicomponent nanostructures and loading thereon with bioactive molecules for potential biomedical applications

Lipolysis of Poly(Hydroxybutyrate)‐Based Films for the Tailored Release of Hydrophilic Proteins

“…The FTIR spectrum of pure BSA depicted a broad O‐H stretching band at 3285 cm ‐1 , and some sharp peaks of C=O and C‐N stretching of the amide group at 1648 and 1383 cm ‐1 , respectively [17] . The spectrum of BSA‐adsorbed PHB/PLA film represents a quite similar pattern with a minimal shift in C=O and C−N stretching vibrational peaks recorded at 1642 and 1376 cm −1 along with a slight change in their intensities, hence indicating the presence of BSA components (Figure 5b).…”

“…The proteins being amphipathic might establish tailor-based interactions (adsorption/desorption) with both hydrophobic and hydrophilic surfaces. [17] The purpose of the present study was to prepare PLAmediated PHB multicomponent films followed by lipase treatment to enhance their hydrophilicity through the insertion of certain polar moieties on them for the tailored impregnation of some test proteins. The extent of lipase treatment was observed by measuring the lipase and hydrolytic activities and water contact angle (WCA) analysis.…”

“…and the nature of the test protein may affect the impregnation and release phenomena. The proteins being amphipathic might establish tailor‐based interactions (adsorption/desorption) with both hydrophobic and hydrophilic surfaces [17] …”