PEGylated Lipid bilayer coated mesoporous silica nanoparticles for co-delivery of paclitaxel and curcumin: Design, characterization and its cytotoxic effect

Lin, Jiahao; Cai, Qiang; Tang, Yinian; Xu, Yong; Wang, Qian; Li, Tingting; Xu, He; Wang, Shuaiyu; Fan, Kai; Liu, Zhongjie; Jin, Yipeng; Lin, Degui

doi:10.1016/j.ijpharm.2017.10.043

Cited by 64 publications

(36 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The cytotoxic activity of the nanoparticles against breast cancer cells in vitro using CCK8 assay was highest at each single time point (48, 60 and 72 h) when compared to free curcumin-paclitaxel mixture solution. Furthermore, in vitro drug release analysis revealed controlled and sustained drug release from the PEGylated lipid bilayer coated silica nanocarriers [71].…”

Section: Polymeric Nanoparticlesmentioning

confidence: 99%

See 1 more Smart Citation

Efficacy of Polymer-Based Nanocarriers for Co-Delivery of Curcumin and Selected Anticancer Drugs

Alven

Aderibigbe

2020

Nanomaterials

View full text Add to dashboard Cite

Cancer remains a heavy health burden resulting in a high rate of mortality around the world. The presently used anticancer drugs suffer from several shortcomings, such as drug toxicity, poor biodegradability and bioavailability, and poor water solubility and drug resistance. Cancer is treated effectively by combination therapy whereby two or more anticancer drugs are employed. Most of the combination chemotherapies result in a synergistic effect and overcome drug resistance. Furthermore, the design of polymer-based nanocarriers for combination therapy has been reported by several researchers to result in promising therapeutic outcomes in cancer treatment. Curcumin exhibits good anticancer activity but its poor bioavailability has resulted in its incorporation into several polymer-based nanocarriers resulting in good biological outcomes. Furthermore, the incorporation of curcumin together with other anticancer drugs have been reported to result in excellent therapeutic outcomes in vivo and in vitro. Due to the potential of polymer-based nanocarriers, this review article will be focused on the design of polymer-based nanocarriers loaded with curcumin together with other anticancer drugs.

show abstract

Section: Polymeric Nanoparticlesmentioning

confidence: 99%

“…Lin et al formulated and characterized poly (ethylene glycol) (PEG)-lipid bilayer coated mesoporous silica nanoparticles for the co-delivery of curcumin and paclitaxel [71]. The drug encapsulation efficiency of curcumin and paclitaxel in the nanoparticles was 77.48% and 30.70%, respectively.…”

Section: Polymeric Nanoparticlesmentioning

confidence: 99%

Efficacy of Polymer-Based Nanocarriers for Co-Delivery of Curcumin and Selected Anticancer Drugs

Alven

Aderibigbe

2020

Nanomaterials

View full text Add to dashboard Cite

show abstract

“…274 More examples on this nanoparticle are available in Table 1. [275][276][277][278][279] Magnetic Nanoparticle (MNP)…”

Section: Mesoporous Silica Nanoparticle (Msn)mentioning

confidence: 99%

<p>Novel Drug Delivery Systems for Loading of Natural Plant Extracts and Their Biomedical Applications</p>

Rahman

Othman

Hammadi

et al. 2020

IJN

145

View full text Add to dashboard Cite

Many types of research have distinctly addressed the efficacy of natural plant metabolites used for human consumption both in cell culture and preclinical animal model systems. However, these in vitro and in vivo effects have not been able to be translated for clinical use because of several factors such as inefficient systemic delivery and bioavailability of promising agents that significantly contribute to this disconnection. Over the past decades, extraordinary advances have been made successfully on the development of novel drug delivery systems for encapsulation of plant active metabolites including organic, inorganic and hybrid nanoparticles. The advanced formulas are confirmed to have extraordinary benefits over conventional and previously used systems in the manner of solubility, bioavailability, toxicity, pharmacological activity, stability, distribution, sustained delivery, and both physical and chemical degradation. The current review highlights the development of novel nanocarrier for plant active compounds, their method of preparation, type of active ingredients, and their biomedical applications.

show abstract

“…6,45 Increase of water solubility can be a contributing factor that decreases the dosage and toxicity of PTX. 46 Additionally, the drug loading in nanocarriers is inuenced by the relative distribution of the drug between the polymeric phase and the aqueous phase, which depends largely on the solid-state solubility of the drug in the nanocarrier matrix. A mixed solvent system of DCM: ethanol (7 : 3) was found to be extremely effective to dissolve both the drugs and polymer; it offered substantial stability to the drugs in the nanoemulsion system with a high EE.…”

Section: Preparation Of Nanoparticlesmentioning

confidence: 99%

A chemotherapeutic approach targeting the acidic tumor microenvironment: combination of a proton pump inhibitor and paclitaxel for statistically optimized nanotherapeutics

et al. 2019

View full text Add to dashboard Cite

show abstract

PEGylated Lipid bilayer coated mesoporous silica nanoparticles for co-delivery of paclitaxel and curcumin: Design, characterization and its cytotoxic effect

Cited by 64 publications

References 33 publications

Efficacy of Polymer-Based Nanocarriers for Co-Delivery of Curcumin and Selected Anticancer Drugs

Efficacy of Polymer-Based Nanocarriers for Co-Delivery of Curcumin and Selected Anticancer Drugs

<p>Novel Drug Delivery Systems for Loading of Natural Plant Extracts and Their Biomedical Applications</p>

A chemotherapeutic approach targeting the acidic tumor microenvironment: combination of a proton pump inhibitor and paclitaxel for statistically optimized nanotherapeutics

Contact Info

Product

Resources

About