Efficacy of Polymer-Based Nanocarriers for Co-Delivery of Curcumin and Selected Anticancer Drugs

Alven, Sibusiso; Aderibigbe, Blessing Atim

doi:10.3390/nano10081556

Cited by 26 publications

(19 citation statements)

References 115 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Turmeric possesses three components including curcumin, bisdemethoxycurcumin and demethoxycurcumin. The most abundant component of turmeric is curcumin [ 21 ]. This yellow pigmented powder is derived from rhizome of turmeric via grinding [ 22 ].…”

Section: Curcumin: Structure and Pharmacokineticsmentioning

confidence: 99%

Polychemotherapy with Curcumin and Doxorubicin via Biological Nanoplatforms: Enhancing Antitumor Activity

et al. 2020

View full text Add to dashboard Cite

Doxorubicin (DOX) is a well-known chemotherapeutic agent extensively applied in the field of cancer therapy. However, similar to other chemotherapeutic agents such as cisplatin, paclitaxel, docetaxel, etoposide and oxaliplatin, cancer cells are able to obtain chemoresistance that limits DOX efficacy. In respect to dose-dependent side effect of DOX, enhancing its dosage is not recommended for effective cancer chemotherapy. Therefore, different strategies have been considered for reversing DOX resistance and diminishing its side effects. Phytochemical are potential candidates in this case due to their great pharmacological activities. Curcumin is a potential antitumor phytochemical isolated from Curcuma longa with capacity of suppressing cancer metastasis and proliferation and affecting molecular pathways. Experiments have demonstrated the potential of curcumin for inhibiting chemoresistance by downregulating oncogene pathways such as MMP-2, TGF-β, EMT, PI3K/Akt, NF-κB and AP-1. Furthermore, coadministration of curcumin and DOX potentiates apoptosis induction in cancer cells. In light of this, nanoplatforms have been employed for codelivery of curcumin and DOX. This results in promoting the bioavailability and internalization of the aforementioned active compounds in cancer cells and, consequently, enhancing their antitumor activity. Noteworthy, curcumin has been applied for reducing adverse effects of DOX on normal cells and tissues via reducing inflammation, oxidative stress and apoptosis. The current review highlights the anticancer mechanism, side effects and codelivery of curcumin and DOX via nanovehicles.

show abstract

Section: Curcumin: Structure and Pharmacokineticsmentioning

confidence: 99%

Polychemotherapy with Curcumin and Doxorubicin via Biological Nanoplatforms: Enhancing Antitumor Activity

et al. 2020

View full text Add to dashboard Cite

show abstract

“…To overcome these problems, the idea of enzyme encapsulation into tailored nanoparticles (NPs) represents one of the most attractive strategies. Among current advances in developed NPs, polymer-based NPs have gained increasing attention as biocompatible, biodegradable, targeted, and versatile platforms [14][15][16][17][18][19][20] for the delivery of a wide array of therapeutic molecules ranging from small molecules [21][22][23][24], peptides [25][26][27][28], proteins and enzymes [2,4,[29][30][31], and genetic material [32][33][34]. The encapsulation of enzymes into polymeric NPs offer several advantages compared to conventional enzyme-based therapy, including: (i) stabilizing and protecting the enzyme; (ii) improving biological activity; (iii) possibility of targeted delivery; (iv) controlling the enzyme release kinetics; (v) improving therapeutic efficacy and safety [10,35,36].…”

Section: Introductionmentioning

confidence: 99%

Tween® Preserves Enzyme Activity and Stability in PLGA Nanoparticles

et al. 2021

View full text Add to dashboard Cite

Enzymes, as natural and potentially long-term treatment options, have become one of the most sought-after pharmaceutical molecules to be delivered with nanoparticles (NPs); however, their instability during formulation often leads to underwhelming results. Various molecules, including the Tween® polysorbate series, have demonstrated enzyme activity protection but are often used uncontrolled without optimization. Here, poly(lactic-co-glycolic) acid (PLGA) NPs loaded with β-glucosidase (β-Glu) solutions containing Tween® 20, 60, or 80 were compared. Mixing the enzyme with Tween® pre-formulation had no effect on particle size or physical characteristics, but increased the amount of enzyme loaded. More importantly, NPs made with Tween® 20:enzyme solutions maintained significantly higher enzyme activity. Therefore, Tween® 20:enzyme solutions ranging from 60:1 to 2419:1 mol:mol were further analyzed. Isothermal titration calorimetry analysis demonstrated low affinity and unquantifiable binding between Tween® 20 and β-Glu. Incorporating these solutions in NPs showed no effect on size, zeta potential, or morphology. The amount of enzyme and Tween® 20 in the NPs was constant for all samples, but a trend towards higher activity with higher molar rapports of Tween® 20:β-Glu was observed. Finally, a burst release from NPs in the first hour with Tween®:β-Glu solutions was the same as free enzyme, but the enzyme remained active longer in solution. These results highlight the importance of stabilizers during NP formulation and how optimizing their use to stabilize an enzyme can help researchers design more efficient and effective enzyme loaded NPs.

show abstract

“…There are several known curcumin derivatives (e.g., demethoxycurcumin, tetrahydrocurcumin, hexahydrocurcumin, octahydrocurcumin) that were designed for improved curcumin absorption, reducing its hydrophobicity and leading to increased membrane permeability [19,35]. For better curcumin mobility, molecules were combined with nanoparticles, micelles (e.g., liposomes) attached with phospholipid complexes [24,[32][33][34][35][36][37]. Interestingly, in leukemic cells, the nanoparticles were able to increase the half-life of curcumin, as well as inhibit cell proliferation and induce apoptosis.…”

Section: Curcuminmentioning

confidence: 99%

Molecular Targets of Natural Compounds with Anti-Cancer Properties

Kubczak

Szustka

Rogalińska

2021

IJMS

View full text Add to dashboard Cite

Cancer is the second leading cause of death in humans. Despite rapid developments in diagnostic methods and therapies, metastasis and resistance to administrated drugs are the main obstacles to successful treatment. Therefore, the main challenge should be the diagnosis and design of optimal therapeutic strategies for patients to increase their chances of responding positively to treatment and increase their life expectancy. In many types of cancer, a deregulation of multiple pathways has been found. This includes disturbances in cellular metabolism, cell cycle, apoptosis, angiogenesis, or epigenetic modifications. Additionally, signals received from the microenvironment may significantly contribute to cancer development. Chemical agents obtained from natural sources seem to be very attractive alternatives to synthetic compounds. They can exhibit similar anti-cancer potential, usually with reduced side effects. It was reported that natural compounds obtained from fruits and vegetables, e.g., polyphenols, flavonoids, stilbenes, carotenoids and acetogenins, might be effective against cancer cells in vitro and in vivo. Several published results indicate the activity of natural compounds on protein expression by its influence on transcription factors. They could also be involved in alterations in cellular response, cell signaling and epigenetic modifications. Such natural components could be used in our diet for anti-cancer protection. In this review, the activities of natural compounds, including anti-cancer properties, are described. The influence of natural agents on cancer cell metabolism, proliferation, signal transduction and epigenetic modifications is highlighted.

show abstract

Efficacy of Polymer-Based Nanocarriers for Co-Delivery of Curcumin and Selected Anticancer Drugs

Cited by 26 publications

References 115 publications

Polychemotherapy with Curcumin and Doxorubicin via Biological Nanoplatforms: Enhancing Antitumor Activity

Polychemotherapy with Curcumin and Doxorubicin via Biological Nanoplatforms: Enhancing Antitumor Activity

Tween® Preserves Enzyme Activity and Stability in PLGA Nanoparticles

Molecular Targets of Natural Compounds with Anti-Cancer Properties

Contact Info

Product

Resources

About