Molecular Targets of Natural Compounds with Anti-Cancer Properties

Kubczak, Małgorzata; Szustka, Aleksandra; Rogalińska, Małgorzata

doi:10.3390/ijms222413659

Cited by 50 publications

(26 citation statements)

References 227 publications

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“…Interestingly, they found that RES restored DOX-induced deficiency of compensated hypertrophic response to the late-onset hypertension, as indicated by the alleviated CMA and increased heart wall thickness (25). Of note, some polyphenolic compounds have shown the effectiveness against cancer cells both in vivo and in vitro (158).…”

Section: Polyphenolic Compoundsmentioning

confidence: 99%

Cardiomyocyte Atrophy, an Underestimated Contributor in Doxorubicin-Induced Cardiotoxicity

Chen

Yan

Yang

2022

Front. Cardiovasc. Med.

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Left ventricular (LV) mass loss is prevalent in doxorubicin (DOX)-induced cardiotoxicity and is responsible for the progressive decline of cardiac function. Comparing with the well-studied role of cell death, the part of cardiomyocyte atrophy (CMA) playing in the LV mass loss is underestimated and the knowledge of the underlying mechanism is still limited. In this review, we summarized the recent advances in the DOX-induced CMA. We found that the CMA caused by DOX is associated with the upregulation of FOXOs and “atrogenes,” the activation of transient receptor potential canonical 3-NADPH oxidase 2 (TRPC3-Nox2) axis, and the suppression of IGF-1-PI3K signaling pathway. The imbalance of anabolic and catabolic process may be the common final pathway of these mechanisms. At last, we provided some strategies that have been demonstrated to alleviate the DOX-induced CMA in animal models.

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Section: Polyphenolic Compoundsmentioning

confidence: 99%

Cardiomyocyte Atrophy, an Underestimated Contributor in Doxorubicin-Induced Cardiotoxicity

Chen

Yan

Yang

2022

Front. Cardiovasc. Med.

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“…In addition, some of them can cross the BBB and this property is one of the main considerations for the development of therapies for the CNS [ 43 ]. The antioxidant nature and chemopreventive potential against cancer has been recognized for a wide range of natural compounds, including curcumin, epigallocatechin (EGCG), and resveratrol (RES) [ 44 ]. The main focus of our review work is to discuss the effect of these natural compounds in the prevention and treatment of glioblastoma.…”

Section: Natural Compounds In the Therapy Of Gliomamentioning

confidence: 99%

Natural Compounds as Promising Adjuvant Agents in The Treatment of Gliomas

Persano

Gigli

Leporatti

2022

IJMS

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In humans, glioblastoma is the most prevalent primary malignant brain tumor. Usually, glioblastoma has specific characteristics, such as aggressive cell proliferation and rapid invasion of surrounding brain tissue, leading to a poor patient prognosis. The current therapy—which provides a multidisciplinary approach with surgery followed by radiotherapy and chemotherapy with temozolomide—is not very efficient since it faces clinical challenges such as tumor heterogeneity, invasiveness, and chemoresistance. In this respect, natural substances in the diet, integral components in the lifestyle medicine approach, can be seen as potential chemotherapeutics. There are several epidemiological studies that have shown the chemopreventive role of natural dietary compounds in cancer progression and development. These heterogeneous compounds can produce anti-glioblastoma effects through upregulation of apoptosis and autophagy; allowing the promotion of cell cycle arrest; interfering with tumor metabolism; and permitting proliferation, neuroinflammation, chemoresistance, angiogenesis, and metastasis inhibition. Although these beneficial effects are promising, the efficacy of natural compounds in glioblastoma is limited due to their bioavailability and blood–brain barrier permeability. Thereby, further clinical trials are necessary to confirm the in vitro and in vivo anticancer properties of natural compounds. In this article, we overview the role of several natural substances in the treatment of glioblastoma by considering the challenges to be overcome and future prospects.

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“…The anti-oxidant capabilities of polyphenols have a knock-on effect of regulating micro-environments by scavenging ROS and reduce oxidative stress, resulting in reductions in inflammation, or cancer cell proliferation and the effects of other metabolic diseases ( Section 4.2 ), while further being capable of directly interacting with proteins, enzymes, and other metabolites within immunological and metabolic pathways. The relationships between epigenetic effects of polyphenols and immune responses, anti-cancer effects, and other diseases have been reviewed extensively [ 158 , 159 , 169 , 177 ]). Despite this, the effects of various polyphenols in vivo are not as well tested outside of murine models, although there has been an increased focus on how supplementation of farm animals such as pigs with dietary polyphenols can result in increases in anti-oxidant activity, reductions in inflammatory biomarkers, and changes in microbiome species populations ( Section 3.4 ).…”

Section: Health Effects Of Dietary Polyphenols In Pigs and Other Animalsmentioning

confidence: 99%

Polyphenols: Bioavailability, Microbiome Interactions and Cellular Effects on Health in Humans and Animals

2022

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Polyphenolic compounds have a variety of functions in plants including protecting them from a range of abiotic and biotic stresses such as pathogenic infections, ionising radiation and as signalling molecules. They are common constituents of human and animal diets, undergoing extensive metabolism by gut microbiota in many cases prior to entering circulation. They are linked to a range of positive health effects, including anti-oxidant, anti-inflammatory, antibiotic and disease-specific activities but the relationships between polyphenol bio-transformation products and their interactions in vivo are less well understood. Here we review the state of knowledge in this area, specifically what happens to dietary polyphenols after ingestion and how this is linked to health effects in humans and animals; paying particular attention to farm animals and pigs. We focus on the chemical transformation of polyphenols after ingestion, through microbial transformation, conjugation, absorption, entry into circulation and uptake by cells and tissues, focusing on recent findings in relation to bone. We review what is known about how these processes affect polyphenol bioactivity, highlighting gaps in knowledge. The implications of extending the use of polyphenols to treat specific pathogenic infections and other illnesses is explored.

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Molecular Targets of Natural Compounds with Anti-Cancer Properties

Cited by 50 publications

References 227 publications

Cardiomyocyte Atrophy, an Underestimated Contributor in Doxorubicin-Induced Cardiotoxicity

Cardiomyocyte Atrophy, an Underestimated Contributor in Doxorubicin-Induced Cardiotoxicity

Natural Compounds as Promising Adjuvant Agents in The Treatment of Gliomas

Polyphenols: Bioavailability, Microbiome Interactions and Cellular Effects on Health in Humans and Animals

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