&lt;p&gt;Novel Drug Delivery Systems for Loading of Natural Plant Extracts and Their Biomedical Applications&lt;/p&gt;

Rahman, Heshu Sulaiman; Othman, Hemn Hassan; Hammadi, Nahidah Ibrahim; Yeap, Swee Keong; Amin, Kawa; Samad, Nozlena Abdul; Alitheen, Noorjahan Banu

doi:10.2147/ijn.s227805

Cited by 128 publications

(67 citation statements)

References 321 publications

(307 reference statements)

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“…The absorption was found to increase to 3–17% when quercetin was consumed in a glycosidic bond compared to its aglycone form ( 53 ). Different delivery systems using nanotechnology have since been developed to further improve its water solubility and bioavailability, for example, by binding it to solid lipid carriers or nanosized polymeric micelles ( 54 ). A pharmacokinetic study in beagle dogs showed that quercetin encapsulated in polymeric micelles induces a 2.19-fold longer half-life and a relative oral bioavailability increased by 286% as compared to free quercetin ( 55 ).…”

Section: Quercetinmentioning

confidence: 99%

Therapeutic Potential of Quercetin to Alleviate Endothelial Dysfunction in Age-Related Cardiovascular Diseases

Dagher

Mury

Thorin‐Trescases

et al. 2021

Front. Cardiovasc. Med.

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The vascular endothelium occupies a catalog of functions that contribute to the homeostasis of the cardiovascular system. It is a physically active barrier between circulating blood and tissue, a regulator of the vascular tone, a biochemical processor and a modulator of coagulation, inflammation, and immunity. Given these essential roles, it comes to no surprise that endothelial dysfunction is prodromal to chronic age-related diseases of the heart and arteries, globally termed cardiovascular diseases (CVD). An example would be ischemic heart disease (IHD), which is the main cause of death from CVD. We have made phenomenal advances in treating CVD, but the aging endothelium, as it senesces, always seems to out-run the benefits of medical and surgical therapies. Remarkably, many epidemiological studies have detected a correlation between a flavonoid-rich diet and a lower incidence of mortality from CVD. Quercetin, a member of the flavonoid class, is a natural compound ubiquitously found in various food sources such as fruits, vegetables, seeds, nuts, and wine. It has been reported to have a wide range of health promoting effects and has gained significant attention over the years. A growing body of evidence suggests quercetin could lower the risk of IHD by mitigating endothelial dysfunction and its risk factors, such as hypertension, atherosclerosis, accumulation of senescent endothelial cells, and endothelial-mesenchymal transition (EndoMT). In this review, we will explore these pathophysiological cascades and their interrelation with endothelial dysfunction. We will then present the scientific evidence to quercetin's anti-atherosclerotic, anti-hypertensive, senolytic, and anti-EndoMT effects. Finally, we will discuss the prospect for its clinical use in alleviating myocardial ischemic injuries in IHD.

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Section: Quercetinmentioning

confidence: 99%

Therapeutic Potential of Quercetin to Alleviate Endothelial Dysfunction in Age-Related Cardiovascular Diseases

Dagher

Mury

Thorin‐Trescases

et al. 2021

Front. Cardiovasc. Med.

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“…Some photochemicals obtained through plant extract also exhibit low solubility. This brings difficult challenges for the development of drug delivery systems [ 164 ]. On the other hand, only a few new drugs are considered as class I or III, that is, when the maximum clinical dose is dissolved in 250 mL of water in a pH range from 1.2 to 6.8 [ 165 ].…”

Section: Bioengineered Thermo-responsive Scaffoldsmentioning

confidence: 99%

Exploration of Bioengineered Scaffolds Composed of Thermo-Responsive Polymers for Drug Delivery in Wound Healing

Henríquez

Castro-Alpízar

Lopretti-Correa

et al. 2021

IJMS

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Innate and adaptive immune responses lead to wound healing by regulating a complex series of events promoting cellular cross-talk. An inflammatory response is presented with its characteristic clinical symptoms: heat, pain, redness, and swelling. Some smart thermo-responsive polymers like chitosan, polyvinylpyrrolidone, alginate, and poly(ε-caprolactone) can be used to create biocompatible and biodegradable scaffolds. These processed thermo-responsive biomaterials possess 3D architectures similar to human structures, providing physical support for cell growth and tissue regeneration. Furthermore, these structures are used as novel drug delivery systems. Locally heated tumors above the polymer lower the critical solution temperature and can induce its conversion into a hydrophobic form by an entropy-driven process, enhancing drug release. When the thermal stimulus is gone, drug release is reduced due to the swelling of the material. As a result, these systems can contribute to the wound healing process in accelerating tissue healing, avoiding large scar tissue, regulating the inflammatory response, and protecting from bacterial infections. This paper integrates the relevant reported contributions of bioengineered scaffolds composed of smart thermo-responsive polymers for drug delivery applications in wound healing. Therefore, we present a comprehensive review that aims to demonstrate these systems’ capacity to provide spatially and temporally controlled release strategies for one or more drugs used in wound healing. In this sense, the novel manufacturing techniques of 3D printing and electrospinning are explored for the tuning of their physicochemical properties to adjust therapies according to patient convenience and reduce drug toxicity and side effects.

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“…Currently, many nanomedicines that are used for cancer therapy and approved by the U.S. Food and Drug Administration (FDA), are extracted from natural compounds, such as Doxorubicin, Paclitaxel, Vincristin, Kaempferol, Silamarin, Resveratrol and Curcumin [ 23 , 168 , 169 , 170 , 171 ].…”

Section: Fda Approved Nanodevicesmentioning

confidence: 99%

Drug Delivery Systems of Natural Products in Oncology

Colone¹,

Calcabrini²,

Stringaro³

2020

Molecules

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In recent decades, increasing interest in the use of natural products in anticancer therapy field has been observed, mainly due to unsolved drug-resistance problems. The antitumoral effect of natural compounds involving different signaling pathways and cellular mechanisms has been largely demonstrated in in vitro and in vivo studies. The encapsulation of natural products into different delivery systems may lead to a significant enhancement of their anticancer efficacy by increasing in vivo stability and bioavailability, reducing side adverse effects and improving target-specific activity. This review will focus on research studies related to nanostructured systems containing natural compounds for new drug delivery tools in anticancer therapies.

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<p>Novel Drug Delivery Systems for Loading of Natural Plant Extracts and Their Biomedical Applications</p>

Cited by 128 publications

References 321 publications

Therapeutic Potential of Quercetin to Alleviate Endothelial Dysfunction in Age-Related Cardiovascular Diseases

Therapeutic Potential of Quercetin to Alleviate Endothelial Dysfunction in Age-Related Cardiovascular Diseases

Exploration of Bioengineered Scaffolds Composed of Thermo-Responsive Polymers for Drug Delivery in Wound Healing

Drug Delivery Systems of Natural Products in Oncology

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