Peer Reviewed: Numerical Simulation of Aerosol Transport in Atomic Spectrometry

Optimisation of a laser ablation cell for detection of hetero-elements in proteins blotted onto membranes by use of inductively coupled plasma mass spectrometry

“…The strong change in the temporal signal shape in the second part of the cylindrical cell with the insertion present suggests an abrupt change of the gas flow conditions in the middle of the cell, which could be confirmed (not shown here) by modelling of the gas flow characteristics with a computational fluid dynamics programme. 34 Unfortunately, the peak area shows a similar drop comparable to the CC, which hints at aerosol losses and was also observed by Bleiner and Guenther, previously. 25 As mentioned above, the FC type has some additional dead volume around the rotating cylinder, which is not in the direct flow-path of the gas, but can attribute to some additional dead volume effects.…”

Review of the applications of laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS) to the analysis of biological samples

“…However, signicant changes in the aerosol transport efficiency were not observed for ablation cells with different volumes as well as for different lengths of the transfer lines. 42 The cell design and simulations of the aerosol behavior and its transport were investigated, 41,[43][44][45][46][47] with the purpose of predicting the dispersion of the aerosol and nding the parameters that affect its loss in the ablation cell. The inuence of the sample characteristics must also be considered and the manufacturers of LA systems in general provide cells to accommodate samples of different size.…”

“…The isotopes 43 Ca or 44 Ca were used to normalize the analyte signal in teeth layers [86][87][88] and bone, [89][90][91] but it has been claimed that Ca varies signicantly within the tooth. 92 Sulphur is a keratin matrix element and the isotopes 34 S and 32 S have been effectively used as the IS in the analysis of hair, 93,94 33 S in tortoise shells 95 and 32 S in nails.…”

A model for the generation of small particles in laser ablation ICP-MS

“…Obviously, the atomized material cannot be transported over longer distances as is commonly done in LA-ICP measurements. 2,3 In addition, clear evidence has been produced that the material evaporated in the interaction zone of the laser is converted into an aerosol. [3][4][5][6][7][8][9][10][11][12][13][14] A recent review article summarizes the state of current research and theoretical knowledge.…”