Peer Reviewed: Charge-Transfer Devices in Analytical Instrumentation

Hanley, Quentin S.; Earle, Colin W.; Pennebaker, Frank M.; Madden, Sean; Denton, M. Bonner

doi:10.1021/ac9621229

Cited by 48 publications

(18 citation statements)

References 24 publications

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“…The charge-coupled device (CCD) is a new class of multi-channel solid-state detectors (Hanley et al, 1996). It has been used as a sensitive detector in CE (Xiong et al, 1996a).…”

Section: à18mentioning

confidence: 99%

Capillary electrophoresis of catecholamines with laser‐induced fluorescence intensified charge‐coupled device detection

Xiong

Han

Zhao

et al. 2001

Biomedical Chromatography

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A capillary electrophoresis-laser-induced fluorescence-intensified charge-coupled device system was used for the separation and determination of catecholamines. Optimization of derivatization and separation conditions was investigated in order to reach a high separation efficiency and sensitivity. All fluorecein isothiocyanate derivatives of catecholamines were satisfactorily separated within 12 min. The detection limits were in attomole ranges. This method allows determination of catecholamines with high separation efficiencies and sensitivity.

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“…The charge-coupled device (CCD) is a new class of multi-channel solid-state detectors (Hanley et al, 1996). It has been used as a sensitive detector in CE (Xiong et al, 1996a).…”

Section: à18mentioning

confidence: 99%

Capillary electrophoresis of catecholamines with laser‐induced fluorescence intensified charge‐coupled device detection

Xiong

Han

Zhao

et al. 2001

Biomedical Chromatography

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“…However, a suitable array detection system must either possess many parallel counting channels or, if multiplexed, must operate on an extremely fast time scale. Alternatively, an array detector that accumulates and integrates the signal for an extended period of time (0.01-100 seconds) before reading data to storage, in a manner analogous to charge-transfer devices used in emission spectrometry [26], would be desirable. Figure 2 shows non-ratioed signal precision (% RSD) for three different isotope pairs, 107,109 Ag, 20,22 Ne, and 12,13 C, as a function of accumulated counts.…”

Section: Duty Cyclementioning

confidence: 99%

Simultaneous or scanning data acquisition? A theoretical comparison relevant to inductively coupled plasma sector-field mass spectrometers

Solyom

Hieftje

2003

J. Am. Soc. Mass Spectrom.

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The benefits of simultaneous multichannel detection over single-channel scanning detection are well established in analytical chemistry. Multichannel detection increases duty cycle, which leads to enhanced sensitivity, detection limits, and reduced analysis time. Also, multichannel detection used with either isotope-ratio or internal-standard techniques provides a mechanism to reduce the effect of multiplicative or flicker noise prevalent in plasma sources. An additional benefit of simultaneous detection is superior analysis of short-lived transient signals. Presented here is a theoretical comparison between simultaneous/continuous multichannel acquisition and single-channel scanning acquisition. To conduct this comparison, reported sensitivity, single-channel precision, and background values for commercial inductively coupled plasma sector-field mass spectrometers (ICP-SFMS) are used to generate theoretical figures of merit for both acquisition methods. Among the figures of merit that will be considered are detection limits, precision, and analysis time, particularly for multi-element or multi-isotope analysis. (J Am Soc Mass Spectrom 2003, 14, 227-235)

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“…The emission spectroscopy market is a case in point virtually all ICP emission spectrometers today employ CTD devices as detectors. The group has also developed CTD technology for other optical techniques, including fluorescence, Raman, and x-ray diffraction spectroscopy (Hanley et al 1996). The Denton group thus brings invaluable experience and contacts to the proposed research effort.…”

Section: Detection Efficiencymentioning

confidence: 99%

Annual Report 2000 Macromolecular Structure and Dynamics

Koppenaal¹,

Ellis²,

Smith³

2001

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Cover Photo: A molecular model of a single-stranded DNA 9-mer (ball and stick chain) bound to XPA-MBD oriented in the 3′ → 5′ direction that illustrates how the elements of secondary structure are organized in relation to the DNA. The XPA-DNA interactions were characterized by NMR spectroscopy.Other post-genomic-era research activities within the Macromolecular Structure and Dynamics Program include structural genomics, DNA recognition and repair, protein dynamics/interactions, and proteomics. The molecular level understanding of biological processes and the impacts of anthropogenic activities on these processes provide fundamental new insights into the intricacies of complex biological machinery.

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Peer Reviewed: Charge-Transfer Devices in Analytical Instrumentation

Cited by 48 publications

References 24 publications

Capillary electrophoresis of catecholamines with laser‐induced fluorescence intensified charge‐coupled device detection

Capillary electrophoresis of catecholamines with laser‐induced fluorescence intensified charge‐coupled device detection

Simultaneous or scanning data acquisition? A theoretical comparison relevant to inductively coupled plasma sector-field mass spectrometers

Annual Report 2000 Macromolecular Structure and Dynamics

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