Annual Report 2000 Macromolecular Structure and Dynamics

Abstract

Cover Photo: A molecular model of a single-stranded DNA 9-mer (ball and stick chain) bound to XPA-MBD oriented in the 3′ → 5′ direction that illustrates how the elements of secondary structure are organized in relation to the DNA. The XPA-DNA interactions were characterized by NMR spectroscopy.Other post-genomic-era research activities within the Macromolecular Structure and Dynamics Program include structural genomics, DNA recognition and repair, protein dynamics/interactions, and proteomics. The molecular level understanding of biological processes and the impacts of anthropogenic activities on these processes provide fundamental new insights into the intricacies of complex biological machinery.