PEDOT Decorated with PtIr Nanoclusters on Carbon Fiber Paper toward Electrocatalytic Reduction of a Hypertensive Drug Olmesartan Medoxomil

Abstract

A facile electrochemical sensor was developed by electrochemical deposition of PtIr nanoparticles on poly(3,4ethylenedioxythiophene) (PEDOT) modified carbon fiber paper electrode (CFP). The modified electrodes were characterized by Field emission scanning electron microscopy (FESEM) with energy-dispersive X-ray spectroscopy (EDS), X-ray diffraction (XRD), RAMAN spectroscopy, Fourier transform infrared spectroscopy (FTIR) and electroanalytical techniques. PtIr-PEDOT modified CFP electrode was used successfully in the determination of an anti-hypertensive prodrug Olmesartan medoxomil (OM) at femtomolar (fM) level for the first time. Under optimal conditions, the prepared electrochemical sensor has shown broad linear range between 0.001 pM and 0.220 pM and superior detection limit of 3.42 fM was observed based on Differential pulse voltammetric (DPV) study. In addition, the designed electrochemical sensor was successfully demonstrated as a novel platform in the electrochemical determination of OM in human urine and pharmaceutical samples.

A facile and economic electrochemical sensor for methylmalonic acid: a potential biomarker for vitamin B12 deficiency

“…This XRD pattern has been compared to that of the bare PGE and PEDOT/PGE as reported in the literature. 21 The PEDOT/PGE XRD patterns show characteristic peaks at 28.5° and 54.8°, which correspond to the interchain planar ring stacking distance of PEDOT. Ag–PEDOT/PGE showed characteristic peaks at 35.3°, 38.7°, 46.9°, and 64.1° corresponding to the (100), (101), and (110) crystal planes (JCPDS File No.…”

“…In addition, the current investigation was validated by making use of the standard addition method and was exposed to linear regression analysis for validating the current investigation. 21 The linear regression eqn (6) is provided below. I p (A) = 2.9895 × 10 −5 [MMA] − 0.0017 ( R 2 = 0.9972)…”

“…20 Polyaniline (PANI), polythiophene (PTh), polyparaphenylene (PPh), polyacetylene (PA), polypyrrole (PPy), and poly(3,4-ethylenedioxythiophene) (PEDOT) are various types of conducting polymers that are extensively used as supporting catalyst materials and electrode modifiers. 21 PEDOT is found to be an interesting conducting polymer and therefore was utilised for electrochemically modifying the bare PGE due to its defect-free network forming ability as a polymer. 22 Deepa et al developed a novel electrochemical sensor (GO/AuNP- g -ATMS- co -AEMA/AA) for the detection of MMA in human blood samples.…”

MnO2 Nanoclusters Decorated on GrapheneModified Pencil Graphite Electrode for Non‐Enzymatic Determination of Cholesterol

“…The electrode surface area of the redox couple was determined using cyclic voltammetry. Graph of peak current (anodic) against square root of scan rate was plotted along with the determination of the respective slopes (Figure S1, Figure S2, Figure S3) . The electrode surface area was calculated by Randles‐Sevciequation (Equation 1) using the slopes, concentration and diffusion coefficient . …”

An aqueous phase TEMPO mediated electrooxidation of 2-thiophenemethanol using MnO2–Pi dispersed nanocarbon spheres on a carbon fiber paper electrode

“…In this regard, various materials are being used to modify the bare electrodes, like conducting polymers, metal nanoparticles, carbon nanomaterials, metal oxides, and semiconductors. [13][14][15] Presently, carbon-based materials such as charcoal, activated carbon, carbon nanotubes, carbon nanobers, fullerenes, graphene, and porous nanocarbons are receiving signicance due to low density, large surface area, good exibility, high mechanical strength, and stability. 16 Among carbon-based materials, the nanocarbon spheres (NCS) exhibit distinguishing advantages, like simple preparation methods, uniform particle size, consistent surface morphology, larger porosity, and specic surface area, good dispersity, higher chemical and thermal stability, excellent biocompatibility, larger ionic and electronic conductivities and higher packing density, when compared to the other forms of carbons.…”