A facile and economic electrochemical sensor for methylmalonic acid: a potential biomarker for vitamin B12 deficiency

Abstract

A facile and cost-effective method based on a modified pencil graphite electrode (PGE) has been developed for the sensing of methylmalonic acid (MMA). The electrode (Ag-PEDOT/PGE) was designed by the...

Electrochemical sensing of B-complex vitamins: current challenges and future prospects with microfluidic integration

“…86 The performance of a sensor depends on the choice of material, which should possess excellent electrocatalytic properties, a high surface area, and stability. Researchers have investigated various materials, such as carbon-based materials, 87,88 metal nanoparticles and composites, 89,90 and conducting polymers, [91][92][93] to enhance the sensitivity and selectivity of sensors. However, nding an ideal electrode material that provides both stability and sensitivity to different vitamins remains an ongoing challenge.…”

Recent Advances in Dietary Sources, Health Benefits, Emerging Encapsulation Methods, Food Fortification, and New Sensor-Based Monitoring of Vitamin B12: A Critical Review

“…Table 3 provides an overview of the latest advancements in electrochemical sensors designed for the detection of VB 12 , including details on electrode composition and modification, sensing methodology, and sensitivity [172][173][174][175][176][177][178][179][180][181][182][183]. Also, the LOD and linear range of VB 12 recognized by some electrochemical sensors are given in Figure 8.…”

“…Moreover, CV curves at different scan rates demonstrate rising redox peak currents and shifts in anodic and cathodic peak potentials, indicating a surface-controlled electrode process on the GCE(ea)/PTH surface (Figure 9). Table 3 shows that most researchers utilized the differential pulse voltammetry (DPV) technique using various electrodes and their modification methods to analyze VB12 [173,175,178,180,181]. Moreover, Singh et al introduced a novel three-dimensional biomimetic imprinted polymer tailored for the selective detection of VB12 using the technique of differential pulse anodic voltammetry (DPAV).…”

Biogenic-magnesium oxide nanoparticles from Bauhinia variegata (Kachnar) flower extract: a sustainable electrochemical approach for vitamin-B12 determination in real fruit juice and milk

“…30 Rajeev et al fabricated a Ag-PEDOT/PGE (Silver-poly(3,4-ethylenedioxythiophene)/pencil graphite electrode) for the facile and economic electrochemical detection of methylmalonic acid. 31 A PdAu-PPy tailored carbon fiber-based paper electrode was fabricated successfully to perform an electrochemical study of methylmalonic acid (MMA) as a biomarker of Vit-B 12 deficiency. The fabricated heavy metal-based PdAu-PPy electrochemical biosensor of MMA is facile, sensitive, and non-enzymatic, but it is hazardous and toxic.…”