Pediatric Osteosarcoma: A Single Institution’s Experience

Vijayakumar, Vani; Lowery, Rachel; Zhang, Xu; Hicks, Chindo; Rezeanu, Luminita; Barr, Jennifer; Giles, Henry; Vijayakumar, Srinivasan; Megason, Gail

doi:10.14423/smj.0000000000000187

Cited by 8 publications

(5 citation statements)

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“…It was reported that the incidence of osteosarcoma is approximately 1-3/1000,000 individuals per year worldwide (1,2). Although combined therapy including surgical methods and multi-chemotherapy have achieved great progress, the overall five-year survival rate of osteosarcoma patients remains low (3,4). Therefore, discovering new targets is urgent for clinical and basic research.…”

Section: Introductionmentioning

confidence: 99%

miR-141-3p suppresses proliferation and promotes apoptosis by targeting GLI2 in osteosarcoma cells

Wang

Liu

et al. 2017

Oncol Rep

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MicroRNAs (miRNAs) have been reported as key regulators in numerous diseases including osteosarcoma. The function of microRNA-141-3p (miR-141-3p) and whether this function is achieved by regulation of GLI family zinc finger 2 (GLI2) in osteosarcoma remain unclear. In the present study, we found decreased expression of miR-141-3p, but increased expression of GLI2 in osteosarcoma tissues and cell lines. In addition, we demonstrated a negative correlation between miR-141-3p and GLI2. Furthermore, we revealed that elevation of miR-141-3p resulted in a marked inhibition of proliferation and promotion of apoptosis as well as an obviously decrease in GLI2 in osteosarcoma cell lines. Furthermore, we determined that GLI2 is a target of miR-141-3p by a constructed luciferase assay. In addition, we showed that miR-141-3p could negatively regulate GLI2 and its downstream parathyroid hormone-related protein 1 (PTHRP1). Finally, through a series of antisense experiments we confirmed that the effect of miR-141-3p on proliferation and apoptosis was achieved through the GLI2 pathway in osteosarcoma cells. The findings of the present study may provide a new target for treating osteosarcoma.

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Section: Introductionmentioning

confidence: 99%

miR-141-3p suppresses proliferation and promotes apoptosis by targeting GLI2 in osteosarcoma cells

Wang

Liu

et al. 2017

Oncol Rep

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“…Pulmonary metastasis occurs in early stages of osteosarcoma, causing high mortality. Osteosarcoma originates from the mesenchymal tissue, and is characterized by spindle stromal cells and osteoid tissue (Vijayakumar et al, 2014;Trosman and Krakovitz, 2015). No obvious clinical symptoms occur in the early phase of osteosarcoma.…”

Section: Introductionmentioning

confidence: 99%

Regulatory role of microRNA184 in osteosarcoma cells

Gr¹,

Wang²,

Xb³

et al. 2015

Genet. Mol. Res.

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“…Most previous studies reported a much lower 5-year OS both in children with Osteosarcoma (31.7%-72.6%) and EWS (19%-70%). 2,[15][16][17][18][19][20][21][22][23] Approximately 30% of our patients with MBT experienced metastasis. More than 60% of metastases occurred in the first 3 months from diagnosis and were associated with higher mortality.…”

Section: Discussionmentioning

confidence: 99%

The Outcome of Children With Malignant Bone Tumors: A Single-Center Experience

Bordbar

Sarfaraz

Haghpanah

et al. 2021

Global Pediatric Health

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Malignant bone tumors (MBT) account for 3% to 5% of cancers in children younger than 15 years. We aimed to report the outcome of children with MBT in 10 years in Southern Iran. During the study period, 100 patients (57 Osteosarcoma, 43 Ewing sarcoma) with an M/F ratio of 1.56 and a median age of 13.8 years (3.8-17.9) were diagnosed. Metastasis occurred in 27% of patients, mostly in the first 3 months of diagnosis. The mean survival time of MBT altogether was 94.1 months (95% CI: 86.5-101.7). The 5-year overall survival and event-free survivals were 85.2% (95% CI: 74%-91.8%) and 69.2% (95% CI: 56%-79%), respectively. Metastasis was the only independent risk factor of death in our study cohort (Hazard ratio 36.7, 95% CI: 4.8-282.6, P = .001) MBT in children mostly occur in adolescent boys. About one-third of them become metastatic, which is significantly associated with poor outcomes.

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Pediatric Osteosarcoma: A Single Institution’s Experience

Cited by 8 publications

References 1 publication

miR-141-3p suppresses proliferation and promotes apoptosis by targeting GLI2 in osteosarcoma cells

miR-141-3p suppresses proliferation and promotes apoptosis by targeting GLI2 in osteosarcoma cells

Regulatory role of microRNA184 in osteosarcoma cells

The Outcome of Children With Malignant Bone Tumors: A Single-Center Experience

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