Peculiarity of Leukemia and Cancer Viruses Based on Our Recent Investigations Utilizing Ultra‐thin Sections by Electronmicrography

Abstract

I. PREFACEFowl leukosis was introduced primarily by ELLERMANN and BANG (1908), while chicken myxosarcoma by FUJINAMI (1909) and successively by Rous (1910) as diseases elicited by filtrable agents. Proliferating modes of these viruses, however, remain yet unclarified, except the only suggestive description of GAYLORD (1955) referring to Rous sarcoma.In respect to the viral tumor in mammals, on the other hand, C3Hmammary cancer called general interest, and especially, electron micrographical studies made by DMOCHOWSKI (1955), BERNHARD (1955), SUZUKI (1957) revealed the attitude of the cancer virus in the host cells, though these findings are thought to be the only exceptional case in mammalian cancer. However, GROSS (1951, 1954, 1957) reported his interesting works concerning leukemia in AK mice to explain the viral origin of this disease by way of his varied experimental procedures, though the proliferating modus of the causative virus is not yet demonstrated in the cytoplasm of leukemic cells by electron micrograph of ultra-thin sections (AMANO,

Comparative Biology: Animal Models of Human Hematologic Disease: A Review

“…The viruses of erythroblastosis and myeloblastosis were later isolated and characterized by BEARD et al [8,9]. These viruses have been visualized under the electronmicroscope and some of their physical characteristics have been determined [2,13]. Although certain specific strains of virus have been reported to produce one type of leukosis, that is, lymphomatosis, erythroblastosis, or myeloblastosis, BEARD [10] has presented evidence that certain homogeneous laboratory virus types have caused each of the pathological entities characteristic of the leukosis complex.…”