E<scp>lectron</scp> M<scp>icroscopical</scp> A<scp>spects of</scp> D<scp>eveloping</scp> M<scp>odes of the</scp> C<scp>ancer</scp> V<scp>irus and the</scp> P<scp>roblem of</scp>“P<scp>seudovirus</scp> P<scp>articles</scp>”

Amano, Shigeyasu; Ichikawa, Yasuo

doi:10.1111/j.1440-1827.1959.tb00325.x

Cited by 2 publications

(1 citation statement)

References 21 publications

(2 reference statements)

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“…Rous sarcoma virus (23), and an agent associated with mammary tumors of mice (24)(25)(26)(27)(28). It is of interest that ejection of virus from vacuoles or extrusion of virus at the surface is encountered in cells which, on morphologic grounds at least, appear to be viable.…”

Section: Viralmentioning

confidence: 99%

Structure and Development of Viruses as Observed in the Electron Microscope

Morgan

Howe

Rose

1961

The Journal of Experimental Medicine

171

105

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Western equine encephalomyelitis (WEE) virus is 40 to 55 m/z in diameter (1) and apparently contains nucleic acid of the ribose type (2, 3). Although electron microscopic examination of whole mounts of tissue cultures infected with a closely related agent (Eastern equine encephalomyelitis virus) has shown viral particles both within and on the surface of cells (4,5), no studies employing thin sections have been previously reported. The purpose of this communication is to illustrate and describe the manner in which WEE virus appears to differentiate within, and gain egress from, infected tissue culture cells as revealed in thin sections by the electron microscope. Similarities in development or release among WEE virus, influenza virus, herpes simplex virus, the virus associated with erythroblastosis of chickens, Rous sarcoma virus and a mouse mammary tumor agent will be discussed. Stable human amnionic cells:A stable line of human anauionic epithelium was kindly supplied by Dr. Katherine Sprnnt. Replicate cultures were prepared in Leighton tubes without coverslip% using Eagle's basal medium with 10 per cent horse serum. The cultures were inocu-* These studies were aided

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Section: Viralmentioning

confidence: 99%

Structure and Development of Viruses as Observed in the Electron Microscope

Morgan

Howe

Rose

1961

The Journal of Experimental Medicine

171

105

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Electron microscopic study of virus particles in reproductive organs of mice inoculated with leukemia virus (Moloney)

Chopra

Durr

1968

Intl Journal of Cancer

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Ultra‐thin sections of various reproductive organs of BALB/c mice inoculated with Moloney leukemia virus were examined in the electron microscope. Various tissues such as testis, seminal vesicles, prostate, vas deferens, vas efferens, epididymis and ovary revealed the presence of a considerable number of virus particles similar in appearance to those observed in spleen, thymus and bone marrow of leukemic mice. A large number of virus particles were seen budding into the ducts of vas deferens and vas efferens. These morphological studies may point to the possibility that virus produced by infected cells of the male reproductive organs is released into the semen and under suitable circumstances may be transmitted to normal females at coitus through seminal fluid.

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Electron Microscopical Aspects of Developing Modes of the Cancer Virus and the Problem of“Pseudovirus Particles”

Cited by 2 publications

References 21 publications

Structure and Development of Viruses as Observed in the Electron Microscope

Structure and Development of Viruses as Observed in the Electron Microscope

Electron microscopic study of virus particles in reproductive organs of mice inoculated with leukemia virus (Moloney)

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