Peculiarities of Ganglioside-CA2+-Interactions

Probst, Wolfgang; Rahmann, H.

doi:10.1007/978-3-642-71932-5_9

Cited by 13 publications

(2 citation statements)

References 32 publications

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“…It is also well known that a correct intra-axonal concentration of some ions, such as Ca 2+ and Mg 2+ , is required to maintain axoplasmic transport (45) and to regulate cytoskeletal dynamics (46); in fact, these ions are involved in the enzymatic activities (ATPases) of both membrane-and microtubuleassociated proteins. Therefore, exogenous GA, once inserted into the neuronal plasma membrane, might exert an indirect effect on the axonal transport by modulating the mechanisms that control intra-axonal ionic concentration (47).…”

Section: Discussionmentioning

confidence: 99%

Experimental Diabetic Neuropathy: Effect of Ganglioside Treatment on Axonal Transport of Cytoskeletal Proteins

Figliomeni

Bacci²,

Panozzo³

et al. 1992

Diabetes

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Abnormalities in axonal transport of proteins are thought to play an important role in the pathogenesis of diabetic neuropathy. Gangliosides exert a positive action on numerous alterations in biochemistry and physiology of diabetic nerves. This study was undertaken to assess the effects of exogenous gangliosides on the axonal transport of structural proteins such as actin and tubulin in the sensory fibers of short-term (9-wk) and long-term (6-mo) diabetic rats. Adult Sprague-Dawley rats were made diabetic with a single injection of 70 mg/kg streptozocin i.p. Subgroups were injected daily with either highly purified ganglioside mixture (10 mg/kg i.p.) or saline for 1 mo, beginning either 2 or 17 wk after streptozocin injection. Age-matched rats were used as controls. Axonal transport was studied by the pulse-labeling technique. Three weeks after labeling, sciatic nerves were dissected out and processed for sodium dodecyl sulfate-polyacrylamide gel electrophoresis and fluorography. In diabetic rats of both experimental designs, the transport rate of tubulin and actin was decreased by approximately 30% compared with control rats. Ganglioside treatment counteracted such alterations in both 9-wk and 6-mo diabetic rats. These data suggest a pharmacological effect that could be correlated with molecular interactions between integral membrane glycolipids and cytoskeletal elements.

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Section: Discussionmentioning

confidence: 99%

Experimental Diabetic Neuropathy: Effect of Ganglioside Treatment on Axonal Transport of Cytoskeletal Proteins

Figliomeni

Bacci²,

Panozzo³

et al. 1992

Diabetes

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show abstract

“…The effect of gangliosides on functional membrane proteins has been intensively investigated [3], but their direct relation to membrane properties still remains open. With regard to synaptic transmission, calcium-ganglioside complexes may act as neuromodulators, in particular, under different environmental conditions [4][5][6].…”

Section: Introductionmentioning

confidence: 99%

Effect of calcium and temperature on mixed lipid‐valinomycin monolayers A comparison of glycosphingolipids (ganglioside GT1b, sulphatides) and phosphatidylcholine

et al. 1988

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The influence of calcium and temperature on pure lipid (bovine brain PC, sulphatides, ganglioside GTIb), valinomycin and mixed lipid-valinomycin monolayers at the air/water interface was studied. In mixed films, evidence was found that the two components were miscible. On the other hand, at higher surface pressures, phase separation occurs in the cases of PC and sulphatides. Measuring the area requirement and the collapse pressure the stability of both lipid and the peptide was increased in particular due to ganglioside-valinomycin interaction. The addition of 10 -5 M calcium into the subphase at 20 and 37°C and surface pressures of 10 and 20 mN/m led to a condensing effect in ganglioside mixtures, with formation of aggregates as indicated also by the nearly ideal behaviour of two component monolayers.

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Calcium-Ganglioside Interactions and Modulation of Neuronal Functions

Rahmann

1992

Current Aspects of the Neurosciences

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Peculiarities of Ganglioside-CA2+-Interactions

Cited by 13 publications

References 32 publications

Experimental Diabetic Neuropathy: Effect of Ganglioside Treatment on Axonal Transport of Cytoskeletal Proteins

Experimental Diabetic Neuropathy: Effect of Ganglioside Treatment on Axonal Transport of Cytoskeletal Proteins

Effect of calcium and temperature on mixed lipid‐valinomycin monolayers A comparison of glycosphingolipids (ganglioside GT1b, sulphatides) and phosphatidylcholine

Calcium-Ganglioside Interactions and Modulation of Neuronal Functions

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