Pectolinarin and Pectolinarigenin of Cirsium setidens Prevent the Hepatic Injury in Rats Caused by D-Galactosamine via an Antioxidant Mechanism

Yoo, Yeong‐Min; Nam, Jung‐Hwan; Kim, Minyoung; Choi, Jongwon; Park, Hee-Juhn

doi:10.1248/bpb.31.760

Cited by 97 publications

(54 citation statements)

References 23 publications

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“…Pectolinarin isolated of the leaves of Cirsium setidens (Compositae), demonstrated hepatoprotective efficacy in a rat model of hepatic injury caused by D-galactosamine. It was suggested that the activity occurs mainly via SOd (superoxide dismutase) antioxidant mechanism (Yoo et al 2008).…”

Section: Leandro R Simões Et Almentioning

confidence: 99%

Chemical constituents of Distictella elongata (Vahl) Urb. (Bignoniaceae)

Simoes

Maciel

Brandão

et al. 2013

An. Acad. Bras. Ciênc.

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Pectolinarin, a flavone heteroside, was isolated from Distictella elongata (Vahl) Urb. leaves ethanol extract, along with a mixture of ursolic, pomolic and oleanolic acids, besides β-sitosterol. Their structures were established on the basis of spectral analysis ( 1 H and 13 C NMR, 1 D and 2 D) and they were compared with literature. This is the first report on the occurrence of this flavonoid in a species of the Bignoniaceae family.

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Section: Leandro R Simões Et Almentioning

confidence: 99%

Chemical constituents of Distictella elongata (Vahl) Urb. (Bignoniaceae)

Simoes

Maciel

Brandão

et al. 2013

An. Acad. Bras. Ciênc.

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“…Cirsium spp. is also bioactive and has antimicrobial, anti-diabetic, anti-oxidant, hepatoprotective, antiinflammatory, vasorelaxant, and anti-cancer properties (Perez et al 2001;Park et al 2004;Nazaruk and Jakoniuk 2005;Liu et al 2007;Jeong et al 2008;Kim et al 2008;Ku et al 2008;Lim et al 2008;Yoo et al 2008).…”

Section: Introductionmentioning

confidence: 99%

“…Among bioactive phytochemicals, pectolinarin has been isolated as a primary compound in C. setidens (Yoo et al 2008). Pectolinarin has anti-tumor, hepatoprotective, and anti-inflammatory activities (Lim et al 2008;Yoo et al 2008).…”

Section: Introductionmentioning

confidence: 99%

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Determination of pectolinarin inCirsiumspp. using HPLC/UV analysis

Cho

Lee

et al. 2016

JABC

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Pectolinarin was isolated from the ethyl acetate fraction of Cirsium setidens using open column chromatography and was analyzed using spectrometry. Pectolinarin content in Cirsium spp. was determined using HPLC/UV. Pectolinarin content in the aerial part of Cirsium spp. was higher than that in the root and pappus. Pectolinarin content was highest in the aerial part of C. chlorolepis (110.65 mg/g extract). Consequently, the aerial part of C. chlorolepis has potential for use in new natural medicinal products, health supplements, and beverages.

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“…고려엉겅퀴의 지표성분으로는 pectolinarin 및 이의 비배 당체 형태인 pectolinarigenin이 보고되었다 (11,12). Cirsium subcoriaceum으로부터 분리된 pectolinarin은 진통 효과 와 항염 작용이 보고되었고 (13) 는 변화가 없는 것으로 나타났다 (Table 3).…”

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Development and Validation of Analytical Method for Pectolinarin and Pectolinarigenin in Fermented Cirsium setidens Nakai by Bioconversion

Oh¹,

Lee²,

Cho

et al. 2015

Journal of the Korean Society of Food Science and Nutrition

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The aim of this study was to investigate a validation method for determination of pectolinarin and pectolinarigenin in fermented Cirsium setidens Nakai. For validation, the specificity, linearity, precision, accuracy, detection limits, and quantification limits of pectolinarin and pectolinarigenin were measured by HPLC. The results show that the detection limits of pectolinarin and pectolinarigenin were 4.25 μg/mL and 2.46 μg/mL, respectively. The recovery rates of pectolinarin and pectolinarigenin were high in the ranges of 99.7∼104.0% and 99.7∼102.4%, respectively. Inter-day and intra-day precisions of pectolinarin and pectolinarigenin in fermented Cirsium setidens Nakai were 0.9%, 0.5% and 0.5%, 0.2%, respectively. Therefore, application of pectolinarin and pectolinarigenin was validated by an analytical method as a marker compound in Cirsium setidens Nakai.

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Pectolinarin and Pectolinarigenin of Cirsium setidens Prevent the Hepatic Injury in Rats Caused by D-Galactosamine via an Antioxidant Mechanism

Cited by 97 publications

References 23 publications

Chemical constituents of Distictella elongata (Vahl) Urb. (Bignoniaceae)

Chemical constituents of Distictella elongata (Vahl) Urb. (Bignoniaceae)

Determination of pectolinarin inCirsiumspp. using HPLC/UV analysis

Development and Validation of Analytical Method for Pectolinarin and Pectolinarigenin in Fermented Cirsium setidens Nakai by Bioconversion

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