Development and Validation of Analytical Method for Pectolinarin and Pectolinarigenin in Fermented Cirsium setidens Nakai by Bioconversion

Oh, Joosung; Lee, Jin Ha; Cho, MyoungLae; Kim, Jae-Min; Choi, Sun‐Il; Jung, Tae‐Dong; Kim, Younghyun; Lee, Sang-Jong; Lee, Bong Jin; Park, Seon Ju; Lee, Ok‐Hwan

doi:10.3746/jkfn.2015.44.10.1504

Cited by 10 publications

(7 citation statements)

References 22 publications

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“…Food consumption for the previous year was assessed with a food frequency questionnaire (FFQ), which included 114 food items and has been validated elsewhere 23. Dietary intakes of nutrients and food groups were analyzed using CAN-pro 3.0 software (The Korean Nutrition Society, Seoul, Korea).…”

Section: Methodsmentioning

confidence: 99%

Relationship between Milk and Calcium Intake and Lipid Metabolism in Female Patients with Type 2 Diabetes

et al. 2013

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PurposeThis study was conducted to determine the association between intake of milk and dairy products as well as calcium and biomarkers related to lipid metabolism in Korean female patients with type 2 diabetes.Materials and MethodsA cohort of 509 female subjects (mean age: 59.0 years; range: 35-80 years) was recruited from Huh's Diabetes Clinic in Seoul between 2005 and 2010. Dietary intake was assessed using a validated food-frequency questionnaire. Subjects were divided into three groups on the basis of their daily intake of milk and dairy products [<50 g/day (0<50 g/day), 50-200 g/day, and >200 g/day (>200-1201 g/day)] and then further divided into two groups according to their daily calcium intake: below and above the estimated average requirement (EAR).ResultsAfter adjustment for age, body mass index, energy intake, exercise, use of nutritional supplements and cholesterol medication, the level of serum high-density lipoprotein (HDL)-cholesterol was significantly higher in subjects with milk and dairy products consumption of >200 g/day than in subjects in the other two groups. Those subjects with a milk and dairy products consumption of >200 g/day had significantly higher levels of apolipoprotein A-1 and a significantly lower atherogenic index than the other two groups. Patients with a calcium intake above the EAR exhibited a significantly greater serum HDL-cholesterol level than those with a calcium intake below the EAR.ConclusionMilk and dairy products, good sources of calcium, play a positive role in lipid profiles in female patients with type 2 diabetes.

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Section: Methodsmentioning

confidence: 99%

Relationship between Milk and Calcium Intake and Lipid Metabolism in Female Patients with Type 2 Diabetes

et al. 2013

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“…Besides the effects Cirsium setidens Nakai has on anti-oxidant, anti-inflammation, anti-cancer, and anti-adipogenesis [18,21,22,23], it has been supported that Cirsium setidens Nakai contains potential as a natural edible plant against obesity. Moreover through this study, we showed that the fermentation improved the quantity of bioactive compound in Cirsium setidens Nakai [24], which might stimulate the protective mechanisms against abnormalities in obesity. However, the detailed mechanism of how…”

Section: Introductionmentioning

confidence: 65%

“…Extracts were filtered and evaporated under vacuum, dried at -70°C. FCSN was standardized by HPLC (Waters 2695, Waters Co., Milford, MA, USA) [24].…”

Section: Methodsmentioning

confidence: 99%

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Optimized <i>Cirsium setidens</i> Nakai Fermented by <i>Lentinula edodes</i> Attenuates Lipid Accumulation by Regulating Fatty Acid Oxidation-mediated Lipolysis in 3T3-L1 Cells and High Calorie Diet-induced Obese Zebrafish

Kim¹,

Lee²,

Lee³

et al. 2017

JFNR

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Cirsium setidens Nakai is an edible herb. Previously we found that fermented Cirsium setidens Nakai (FCSN) has a large amount of major bioactive compound compared to Cirsium setidens Nakai. In this study, we aimed to examine the anti-obesity effect of FCSN using 3T3-L1 cells in vitro and high calorie diet-induced obese (HDIO) zebrafish model in vivo. Our results demonstrated that FCSN significantly inhibited intracellular lipid accumulation in 3T3-L1 cells. FCSN was shown to reduce the expressions of crucial adipocyte differentiation markers, including PPARγ and aP2. FCSN also decreased the production of ROS due to the up-regulated expressions of SOD1, SOD2, GPx, and catalase. Furthermore, we observed that FCSN also altered the levels of energy metabolism and β-oxidation-associated genes such as AMPK, ACC, and CPT-1. In addition, ATGL, a key lipolysis enzyme, was stimulated while the differentiation of 3T3-L1 was suppressed by FCSN. Strikingly, we found that FCSN dramatically increased both the energy metabolism and β-oxidation associated genes and subsequently prevented the increase of body fat accumulation in high calorie diet-induced obese zebrafish. Taken together, this is the first study that demonstrates that FCSN has the beneficial activity to suppress adipogenesis in 3T3-L1 cells and ameliorate an obese-associated health condition in vivo.

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“…This questionnaire has been validated previously and also includes questions about whether the child has eaten 113 food items during the preceding year. The amount of each food item that was eaten is measured by using nine non-overlapping intake frequencies (ranging from “rarely eaten” to “eaten more than three times per day”) together with three portion sizes (small, average, and large) [35]. The food and dietary intake is assessed by using a computerized nutrient-intake assessment software program (CAN-Pro 3.0; Korean Nutrition Society, Seoul, Korea) [36].…”

Section: Methodsmentioning

confidence: 99%

The Cohort for Childhood Origin of Asthma and allergic diseases (COCOA) study: design, rationale and methods

et al. 2014

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BackgroundThis paper describes the background, aim, and design of a prospective birth-cohort study in Korea called the COhort for Childhood Origin of Asthma and allergic diseases (COCOA). COCOA objectives are to investigate the individual and interactive effects of genetics, perinatal environment, maternal lifestyle, and psychosocial stress of mother and child on pediatric susceptibility to allergic diseases.Methods/DesignThe participants in COCOA represents a Korean inner-city population. Recruitment started on 19 November, 2007 and will continue until 31 December, 2015. Recruitment is performed at five medical centers and eight public-health centers for antenatal care located in Seoul. Participating mother-baby pairs are followed from before birth to adolescents. COCOA investigates whether the following five environmental variables contribute causally to the development and natural course of allergic diseases: (1) perinatal indoor factors (i.e. house-dust mite, bacterial endotoxin, tobacco smoking, and particulate matters 2.5 and 10), (2) perinatal outdoor pollutants, (3) maternal prenatal psychosocial stress and the child’s neurodevelopment, (4) perinatal nutrition, and (5) perinatal microbiome. Cord blood and blood samples from the child are used to assess whether the child’s genes and epigenetic changes influence allergic-disease susceptibility. Thus, COCOA aims to investigate the contributions of genetics, epigenetics, and various environmental factors in early life to allergic-disease susceptibility in later life. How these variables interact to shape allergic-disease susceptibility is also a key aim.The COCOA data collection schedule includes 11 routine standardized follow-up assessments of all children at 6 months and every year until 10 years of age, regardless of allergic-disease development. The mothers will complete multiple questionnaires to assess the baseline characteristics, the child’s exposure to environmental factors, maternal pre- and post-natal psychological stress, and the child’s neurodevelopment, nutritional status, and development of allergic and respiratory illnesses. The child’s microbiome, genes, epigenetics, plasma cytokine levels, and neuropsychological status, the microbiome of the residence, and the levels of indoor and outdoor pollutants are measured by standard procedures.DiscussionThe COCOA study will improve our understanding of how individual genetic or environmental risk factors influence susceptibility to allergic disease and how these variables interact to shape the phenotype of allergic diseases.

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Development and Validation of Analytical Method for Pectolinarin and Pectolinarigenin in Fermented Cirsium setidens Nakai by Bioconversion

Cited by 10 publications

References 22 publications

Relationship between Milk and Calcium Intake and Lipid Metabolism in Female Patients with Type 2 Diabetes

Relationship between Milk and Calcium Intake and Lipid Metabolism in Female Patients with Type 2 Diabetes

Optimized <i>Cirsium setidens</i> Nakai Fermented by <i>Lentinula edodes</i> Attenuates Lipid Accumulation by Regulating Fatty Acid Oxidation-mediated Lipolysis in 3T3-L1 Cells and High Calorie Diet-induced Obese Zebrafish

The Cohort for Childhood Origin of Asthma and allergic diseases (COCOA) study: design, rationale and methods

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