PDA-coated CPT@MIL-53(Fe)-based theranostic nanoplatform for pH-responsive and MRI-guided chemotherapy

Abstract

Theranostic nanoplatform for multimodal diagnosis and treatment of tumors is a currently research hotspot in the field of nanomedicine. MOF-based theranostic nanoplatforms of integrating drug delivery with magnetic resonance imaging...

Current status of Fe-based MOFs in biomedical applications

“…The result is a multifunctional therapeutic platform that overcomes weak dispersion and colloidal stability of MIL-53(Fe) and improves biocompatibility. 120…”

“…The result is a multifunctional therapeutic platform that overcomes weak dispersion and colloidal stability of MIL-53(Fe) and improves biocompatibility. 120 Besides, poly(lactic acid) (PLA) and poly(ethylene glycol) (PEG) are also good surface modifiers to obtain excellent controlled drug release and good biocompatibility to reduce side effects on normal cells. Wang et al designed a small metal-organic backbone MIL-loaded with the chemotherapeutic drug dihydroartemisinin (DHA) and MB photosensitizer to prepare MIL-101(Fe) as an intelligent delivery system.…”

Temozolomide and chloroquine co-loaded mesoporous silica nanoparticles are effective against glioma

“…For the vast majority of drug carriers and ligands, PDA can be easily functionalized with a surface to have an anchoring point effect and further bind with ligand molecules [ 9 ]. Additionally, PDA is stable under alkaline conditions but decomposes under acidic conditions; these features can be exploited to achieve pH-responsive release in tumor tissues and intratumoral lysosomes [ 10 , 11 ].…”

pH-Responsive Metal–Organic Framework Thin Film for Drug Delivery

“…More importantly, selective MOFs and their composites exhibit stimuli-responsive behaviors toward endogenous and exogenous stimuli when being applied as drug delivery systems. , For instance, zeolitic imidazolate framework-8 (ZIF-8), composed of Zn 2+ and 2-methylimidazole (a pH-sensitive group), was used for intracellular delivery of DNA polymerase and nucleic acid probes when the pH drops below 6 . Another type of MOF-based material, polydopamine-functionalized MIL-53­(Fe), was reported to be loaded with an antitumor drug, camptothecin, with pH-sensitive drug release profiles …”

“… 23 Another type of MOF-based material, polydopamine-functionalized MIL-53(Fe), was reported to be loaded with an antitumor drug, camptothecin, with pH-sensitive drug release profiles. 24 …”