Pax7-expressing satellite cells are indispensable for adult skeletal muscle regeneration

Abstract

There was an error published in Development 138, 3647-3656.The panel labels on the left indicating genotypes were misaligned in Fig. 5A. The corrected Fig. 5 appears in full below.The authors apologise to readers for this mistake.

Endothelial juxtaposition of distinct adult stem cells activates angiogenesis signaling molecules in endothelial cells

“…Accumulating evidence from different experiments suggests that these cells are emerging as therapeutics for the augmentation of angiogenesis in some pathologies such as prolonged myocardial and muscular ischemia (Mima et al 2012;Sambasivan et al 2011;Tang et al 2009). In the coculture of rat SCs and microvascular fragments, the index of angiogenesis was greater than that of single cell culture (Rhoads et al 2009).…”

Exercise and Stem Cells

“…108 Studies that allow for the conditional ablation of the Pax7 + satellite cell have clearly delineated an important role for the satellite cell in muscle repair and regeneration in response to injury following myotoxin exposure or mechanical overload. 109,110 The satellite cell indeed exhibits limited potential for differentiation aside from myogenesis, 111 and nearly all studies to date have focused on the satellite cell in the context of muscle repair and adaptation to injury.…”

Transplantation of Myogenic Cells in Duchenne Muscular Dystrophy Patients

“…Myoblast transplantation was studied by several different teams in a wide range of animal models such as mice [9], rats [10,11], dogs [12,13], monkeys [14], rabbits [15,16], and pigs [17]. The selective removal of satellite cells in mice makes myofiber regeneration impossible [18][19][20], demonstrating the pivotal and seemingly exclusive role of satellite cells and their progeny, myoblasts, in myofiber regeneration. In spite of that, it should be mentioned that other cells were reported to have some myogenic capacities under some experimental conditions.…”

“…It is intriguing that in transplantation experiments, these "heterodox" myogenic cells were reported to be as efficient or more efficient than myoblasts to participate in myofiber regeneration, while, in situ, they cannot regenerate myofibers by themselves [18][19][20]. Therefore, the participation of other cells in myofiber regeneration, if it really exists, is irrelevant from a physiological point of view.…”