Exercise and Stem Cells

Boppart, Marni D.; Lisio, Michael De; Witkowski, Sarah

doi:10.1016/bs.pmbts.2015.07.005

Cited by 36 publications

(31 citation statements)

References 149 publications

(172 reference statements)

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“…2013). Much of the work examining the effects of exercise on CPCs has focused on acute exercise bouts, and the consensus from these studies is that acute exercise transiently increases CPCs in the peripheral blood in an intensity‐dependent manner (De Lisio & Parise, ; Boppart et al . 2015; Baker et al .…”

Section: Introductionmentioning

confidence: 99%

“…In obese adults, endurance exercise training (EET) contributes to improved body composition, metabolism and inflammatory profiles (You et al 2013). Much of the work examining the effects of exercise on CPCs has focused on acute exercise bouts, and the consensus from these studies is that acute exercise transiently increases CPCs in the peripheral blood in an intensity-dependent manner (De Lisio & Parise, 2013;Boppart et al 2015;Baker et al 2017;Niemiro et al 2017). However, the effects of EET or training status on CPC content are equivocal (Rakobowchuk et al 2012;Emmons et al 2017).…”

Section: Introductionmentioning

confidence: 99%

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Effects of endurance exercise training on inflammatory circulating progenitor cell content in lean and obese adults

Niemiro

Allen

Mailing

et al. 2018

The Journal of Physiology

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Circulating progenitor cells (CPCs) and subpopulations are normally found in the bone marrow, but can migrate to peripheral tissues to participate in local inflammation and/or remodelling. The purpose of this study was to compare the CPC response, particularly the inflammatory-primed haematopoietic stem and progenitor (HSPC) subpopulation, to a 6 week endurance exercise training (EET) intervention between lean and obese adults. Seventeen healthy weight (age: 23.9 ± 5.4 years, body mass index (BMI): 22.0 ± 2.6 kg m ) and 10 obese (age: 29.0 ± 8.0 years, BMI: 33.1 ± 6.0 kg m ) previously sedentary adults participated in an EET. Blood was collected before and after EET for quantification of CPCs and subpopulations via flow cytometry, colony forming unit assays and plasma concentrations of C-X-C motif chemokine 12 (CXCL12), granulocyte-colony stimulating factor (G-CSF), and chemokine (C-C motif) ligand 2 (CCL2). Exercise training reduced the number of circulating HSPCs and adipose tissue-derived mesenchymal stem cells (AT-MSCs). EET increased the colony forming potential of granulocytes and macrophages irrespective of BMI. EET reduced the number of HSPCs expressing the chemokine receptor CCR2 and the pro-inflammatory marker TLR4. EET-induced changes in adipose tissue-derived MSCs and bone marrow-derived MSCs were negatively related to changes in absolute fitness. Our results indicate that EET, regardless of BMI status, decreases CPCs and subpopulations, particularly those primed for contribution to tissue inflammation.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Effects of endurance exercise training on inflammatory circulating progenitor cell content in lean and obese adults

Niemiro

Allen

Mailing

et al. 2018

The Journal of Physiology

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“…A growing body of evidence supports the notion that exercise, a form of physiological stress, can mobilize HSPCs into circulation [ 16 ]. These data demonstrate that acute exercise-induced HSPC mobilization is transient, while the effects of exercise training on HSPC quantity remain to be fully elucidated [ 17 ]. These data combined with recent studies demonstrating the safety of performing exercise in patients undergoing HSCT support the notion that exercise may be a potential adjuvant therapy to enhance HSPC mobilization and improve HSPC collection from mPB.…”

Section: Introductionmentioning

confidence: 99%

Exercise as an Adjuvant Therapy for Hematopoietic Stem Cell Mobilization

Emmons

Niemiro

Lisio

2016

Stem Cells International

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Hematopoietic stem cell transplant (HSCT) using mobilized peripheral blood hematopoietic stem cells (HSPCs) is the only curative strategy for many patients suffering from hematological malignancies. HSPC collection protocols rely on pharmacological agents to mobilize HSPCs to peripheral blood. Limitations including variable donor responses and long dosing protocols merit further investigations into adjuvant therapies to enhance the efficiency of HSPCs collection. Exercise, a safe and feasible intervention in patients undergoing HSCT, has been previously shown to robustly stimulate HSPC mobilization from the bone marrow. Exercise-induced HSPC mobilization is transient limiting its current clinical potential. Thus, a deeper investigation of the mechanisms responsible for exercise-induced HSPC mobilization and the factors responsible for removal of HSPCs from circulation following exercise is warranted. The present review will describe current research on exercise and HSPC mobilization, outline the potential mechanisms responsible for exercise-induced HSPC mobilization, and highlight potential sites for HSPC homing following exercise. We also outline current barriers to the implementation of exercise as an adjuvant therapy for HSPC mobilization and suggest potential strategies to overcome these barriers.

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“…Exercise itself is a form of physiological stress known to induce an adaptation response (Mooren & Krüger 2015). Specifically, different factors, including growth factors, mechanical strain, hypoxia, inflammation and extracellular matrix composition, are altered by exercise and strongly influence the cell niches and behaviour of mesenchymal stem cells (MSCs) (Boppart et al, 2015;Diaz et al, 2017).…”

Section: Introductionmentioning

confidence: 99%

“…Besides the traditional approach of studying stem cells in the context of embryonic development, stem cells are known to play an essential role in regeneration of skeletal muscle following exercise-induced muscle damage by responding to tissue microenvironment specific signals (Boppart et al, 2015). This fact suggests multipotent MSCs as possible powerful therapeutic agents in tissue regeneration.…”

Section: Introductionmentioning

confidence: 99%

Platelet-poor plasma of athletes is a potent inducer of myogenic differentiation of C2C12 myoblasts

et al. 2020

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Introduction. Blood products, i.e. platelet rich plasma (PRP), leukocyte-poor plasma (PRP) and platelet poor plasma (PPP), have previously been used to improve muscle regeneration. In this study, six months? frozen-stored PPP of individuals who practiced different types of physical exercise was analysed; it could steer mouse C2C12 myoblast cells towards proliferation, migration and myogenic differentiation, and it could affect the morphology/shape of myotubes. Materials and Methods. PPP of male Olympic weightlifters, football players and professional folk dancers, aged 15-19, was collected 12 h post-training and stored for 6 months at -20?C. C2C12 cell proliferation was assessed by MTT test, motility by scratch assay, myogenic differentiation by myotube formation and gelatinase activity by gel-zymography. Results and Conclusions. PPP induced proliferation and migration of C2C12 cells. Proliferative capacity was as follows: weightlifters > dancers > football players; mean migratory capacity was: weightlifters = dancers > football players. PPP induced formation of myotubes; significant inter-individual variations were detected: PPP from weightlifters induced formation of round myotubes, and PPP from football players and dancers induced formation of elongated myotubes. The mean myotube area was as follows: football players > dancers > weightlifters. PPP gelatinolytic activity was observed; it was negatively correlated with C2C12 myoblast proliferation. These results provide general but distinct evidence that PPP of individuals practicing certain types of exercise can specifically modify myoblast morphology/function. This is significant for explaining physiological responses and adaptations to exercise. In conclusion, long-term, frozen-stored PPP preserves its potential to modify myoblast morphology and function. [Project of the Serbian Ministry of Education, Science and Technological Development, Grant no. 175062]

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Exercise and Stem Cells

Cited by 36 publications

References 149 publications

Effects of endurance exercise training on inflammatory circulating progenitor cell content in lean and obese adults

Effects of endurance exercise training on inflammatory circulating progenitor cell content in lean and obese adults

Exercise as an Adjuvant Therapy for Hematopoietic Stem Cell Mobilization

Platelet-poor plasma of athletes is a potent inducer of myogenic differentiation of C2C12 myoblasts

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