Patterns of Peptides and Protein-Associated-Peptide Complexes in Psychiatric Disorders

Abstract

Peptidic neurones may be considered as multisignal intergrators and transducers. When formation or release of peptide outstrips genetically determined breakdown capacity, overflow of peptides to the body fluids and urine may be expected. In this paper, pathological urinary chromatographic patterns of peptides are shown for genetic, functional and mixed disorders. Part symptoms of the disorders may be induced with the biologically isolated and purified peptides as well as with chemically synthesized peptides.

Potential biochemical markers for infantile autism

“…Of the 10 autistic subjects, the fractions eluting from Sephadex G-25 showed only one peptide pattern, whereas Trygstad et al (1980) reported two types of peptidic patterns; A (similar to our finding) and B. Since the peptidic pattern, particularly fraction V, of autistic subjects is distinct from that of controls, it is possible that the distribution found may be useful in the differential diagnosis of the syndrome.…”

“…Although the process resembles schizophrenia in emotional withdrawal, endogenous initiation of activity independent of external inputs, and tendency to repeat the same behavior and mannerisms (Trygstad et al, 1980), autism is clearly distinct from other mental disorders (Rutter, 1974). The failure to form normal social relationships seems central to the syndrome (Kanner, 1958).…”

“…In recent years, two lines of research, one on the mechanism of action of endorphins and the other on the neurophysiology underlying mental diseases, seem to have arrived at the same conclusion, namely, that small peptides are intimately involved in both normal and abnormal behaviors (Trygstad et al, 1980) and that excess amounts generated may spill into urine. Thus, it should be possible to isolate the peptides from urine specimens.…”

“…Since it has been reported by Trygstad et al (1980) that the unique patterns of urinary peptides obtained in autism were of diagnostic value, we developed a chromatographic method for isolating a purified preparation of peptides based, in part, on the method of Reeve et al (1982).…”

Urinary compounds in autism

“…A Scandinavian laboratory technique claimed to identify autism (Trygstad et al. 1980; Gillberg et al.…”