Patterns of brain atrophy in frontotemporal dementia and semantic dementia

Rosen, Howard J.; Gorno‐Tempini, Maria Luisa; Goldman, William P.; Perry, Richard J.; Schuff, Norbert; Weiner, Michael W.; Feiwell, Robert; Kramer, Joel H.; Miller, Bruce L.

doi:10.1212/wnl.58.2.198

Cited by 791 publications

(624 citation statements)

References 47 publications

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“…Some studies have shown atrophy in other brain regions, notably the frontal lobes [39,49,64,69] and the amygdala [4,7,22,39,49,64,78]. It is worth noting that, with the evolution of the disease, SD patients develop executive dysfunction and behavioural symptoms [18], in accordance with the role of the frontal lobes in behaviour regulation.…”

Section: Introductionmentioning

confidence: 87%

“…In sum, only a few studies have applied the VBM procedure in SD [4,25,26,29,48,49,64]. Moreover, two of these studies investigated a small group of patients ([48] N = 4;…”

Section: Introductionmentioning

confidence: 99%

“…[49] N = 6), while Rosen et al [64] compared SD patients with a mixed group of healthy subjects and patients with frontal variant of frontotemporal dementia. Finally, only one study has used the optimized VBM procedure [25] to examine 10 SD patients and the authors showed bilateral atrophy in the inferior, middle and superior temporal lobe, the amygdala, hippocampus and entorhinal cortex with a left hemispheric predominance.…”

Section: Introductionmentioning

confidence: 99%

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Anatomical and functional alterations in semantic dementia: A voxel-based MRI and PET study

Desgranges

Matuszewski

Piolino

et al. 2007

Neurobiology of Aging

138

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Rare studies have used MRI and voxel based morphometry (VBM) to assess atrophy, and only two PET studies used SPM to examine functional changes in semantic dementia (SD). Our aim was to highlight both morphological and functional abnormalities in a same group of 10 SD patients, in the entire brain, using a "state of the art" methodology (optimized VBM procedure, PET data corrected for partial volume effects and voxel based analyses). We also used an extensive neuropsychological battery. We showed that main alterations concerned the left temporal lobe, in accordance with the striking impairment of semantic memory in SD patients, as well as the hippocampal region, which may partly explain their moderate episodic memory deficits. Hypometabolism was more extensive than grey matter loss in both temporal lobes, and specifically concerned the orbitofrontal areas, consistent with the moderate impairment of executive functions and behavioural changes. While PET is more sensitive than MRI, there is striking concordance between morphological and functional abnormalities, which contrast with the discordance observed in Alzheimer"s disease and might be a typical feature of SD.3

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Section: Introductionmentioning

confidence: 87%

“…In sum, only a few studies have applied the VBM procedure in SD [4,25,26,29,48,49,64]. Moreover, two of these studies investigated a small group of patients ([48] N = 4;…”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Anatomical and functional alterations in semantic dementia: A voxel-based MRI and PET study

Desgranges

Matuszewski

Piolino

et al. 2007

Neurobiology of Aging

138

View full text Add to dashboard Cite

show abstract

“…However, a number of recent automated image analysis techniques have been applied to study patterns of cerebral atrophy on MRI. One such technique that has been used extensively in various neurodegenerative disorders [9,45], is voxel-based morphometry (VBM). This technique uses unbiased statistics to assess patterns of cerebral atrophy throughout the whole brain in groups of subjects.…”

Section: Introductionmentioning

confidence: 99%

Imaging correlates of posterior cortical atrophy

Whitwell

Jack

Kantarci

et al. 2007

Neurobiology of Aging

184

143

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The aim of this study was to compare patterns of cerebral atrophy on MRI, and neurochemistry on magnetic resonance spectroscopy (MRS), in subjects with posterior cortical atrophy (PCA) and typical Alzheimer's disease (AD). Voxel-based morphometry was used to assess grey matter atrophy in 38 subjects with PCA, 38 subjects with typical AD, and 38 controls. Clinical data was assessed in all PCA subjects. Single-voxel 1 H MRS located in the posterior cingulate was analyzed in a subset of subjects with PCA, typical AD, and control subjects. PCA showed a pattern of atrophy affecting occipital, parietal and posterior temporal lobes, compared to controls. The pattern was bilateral, but more severe on the right. Subjects with PCA showed greater atrophy in the right visual association cortex than subjects with typical AD, whereas those with AD showed greater atrophy in the left hippocampus than those with PCA. 1 H MRS suggested loss of neuronal integrity and glial activation in subjects with PCA and AD. The differing patterns of atrophy on MRI suggest that PCA should be considered a distinct entity from typical AD.

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“…FTLD is both pathologically and clinically heterogeneous [2][3][4][5][6]. Diseases in the FTLD spectrum involve cortical areas that have been implicated in olfactory processing in functional imaging studies of healthy subjects [7][8][9][10][11][12][13][14] and in human lesion studies [15][16][17][18].…”

Section: Introductionmentioning

confidence: 99%

Odour identification in frontotemporal lobar degeneration

et al. 2007

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Little information is available concerning olfactory processing in frontotemporal lobar degeneration (FTLD). We undertook a case-control study of olfactory processing in three male patients fulfilling clinical criteria for FTLD. Odour identification (semantic analysis) and odour discrimination (perceptual analysis) were investigated using tests adapted from the University of Pennsylvania Smell Identification Test. General neuropsychometry and structural volumetric brain magnetic resonance imaging (MRI) were also performed. The three patients with FTLD exhibited a disorder of olfactory processing with the characteristics of a predominantly semantic (odour identification) deficit. This olfactory deficit was more prominent in patients with greater involvement of the temporal lobes on MRI. Central deficits of odour identification may be more common in FTLD than previously recognised, and these deficits may assist in clinical characterisation.

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Patterns of brain atrophy in frontotemporal dementia and semantic dementia

Cited by 791 publications

References 47 publications

Anatomical and functional alterations in semantic dementia: A voxel-based MRI and PET study

Anatomical and functional alterations in semantic dementia: A voxel-based MRI and PET study

Imaging correlates of posterior cortical atrophy

Odour identification in frontotemporal lobar degeneration

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