Patient-controlled analgesia with lornoxicam vs. dipyrone for acute postoperative pain relief after septorhinoplasty

Abstract

Lornoxicam has better tolerability and is a more effective analgesic than dipyrone when administered by patient-controlled analgesia for postoperative analgesia after septorhinoplasty.

Postoperative pain assessment after septorhinoplasty

“…Although it is well known that rhinosurgery is much more painful than septoplasty, and in a broader sense any kind of surgery on the external nose and nasal skeleton could be signiWcantly painful, there is lack of prospective studies assessing early postoperative pain following rhinoplasty or septorhinoplasty [6,12,13]. The present prospective investigation conWrmed moderate, but therapy-relevant postoperative, pain on the Wrst day after septorhinoplasty, as a mean NRS value of 3.77 for maximal pain was estimated.…”

Effect of Preoperative Pregabalin on Induced Hypotension and Postoperative Analgesia with Functional Endoscopic Sinus Surgery

“…Patients often had early pain after FESS which is aggravated by the existence of nasal tampons [9][10][11]. Neuropathic pain is one component of postoperative pain [12].…”

Preoperative lornoxicam for pain prevention after tonsillectomy in adults

“…It exerts its analgesic effect not only via inhibition of cyclooxygenase (COX) I and II, but also by leading to a release of endogenous dynorphin and beta-endorphin [13]. It has a better tolerability profile and longer duration of effect than other NSAIDs [10,14]. Due to these properties and its availability as a parenteral form, lornoxicam may be favorable for acute perioperative pain management, particularly in patients for whom perioperative oral administration is undesirable [15].…”

“…Due to these properties and its availability as a parenteral form, lornoxicam may be favorable for acute perioperative pain management, particularly in patients for whom perioperative oral administration is undesirable [15]. The selected dose of IV lornoxicam (16 mg) was based on several previous studies [14,[16][17][18], while other clinical trials found that a preoperative dose of 8 mg was efficient for postoperative analgesia [6][7][8][9][10][11]. Although the lower dose provided effective pain relief, lornoxicam 16 mg may produce more potent analgesia and of longer duration [14,17,18].…”

“…It is rapidly eliminated and has a short plasma elimination half-life of three to 5 hours [5]. Preoperative intravenous (IV) administration of lornoxicam reduces postoperative pain after various types of surgery, and it reduces the need for postoperative rescue pain medication [6][7][8][9][10][11]. We hypothesized that preoperative administration of IV lornoxicam 16 mg would provide postoperative analgesia without increasing perioperative blood loss after tonsillectomy in adults.…”