Preoperative lornoxicam for pain prevention after tonsillectomy in adults

Mowafi, Hany A.; Telmessani, Laila; Ismail, Salah A.; Naguib, Maged B.

doi:10.1016/j.jclinane.2010.07.002

Cited by 14 publications

(23 citation statements)

References 26 publications

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“…Furthermore, the plasma concentrations after 0.5 h (1.5 ± 0.61 μg mL −1 ) and 1 h (3.03 ± 0.3 μg mL −1 ) and the C max achieved from 1.5 mg dose LOR mini‐tablets are much higher in comparison to a 4‐mg dose from conventional tablets . LOR 8 mg twice daily is currently considered an effective and tolerable alternative NSAID for use as a sole agent or as part of multimodal analgesia in adults with some formulations providing pain relief after 30 min, whereas preoperative 16 mg LOR provides potent pain relief and prevents the need for post‐operative rescue analgesia . However, the increased absorption achieved from the lower dose mini‐tablets in the present study could provide more dose flexibility and improved therapy for patients.…”

Section: Resultsmentioning

confidence: 99%

Dissolution Enhancement and Formulation of Rapid-Release Lornoxicam Mini-Tablets

Tawfeek

Saleem

Roberts

2014

Journal of Pharmaceutical Sciences

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The aim was to enhance the dissolution of lornoxicam and to produce mini-tablets with an optimised system to provide a rapid release multiparticulate formulation. Lornoxicam systems were prepared through co-evaporation with either PEG or Pluronic® F-68 and adsorption onto Neusilin® US2 alone or co-adsorption in the presence of different amounts of polysorbate 80. All systems were characterised by FT-IR, DSC, XRD, flowability and dissolution techniques. Mini-tablets were prepared using the system with the optimum dissolution profile and flowability. Tensile strengths, content uniformity and dissolution profiles of the mini-tablets were evaluated. The effects of different excipients and storage conditions on mini-tablet properties were also studied. The optimised rapid release lornoxicam mini-tablets were further evaluated for their in-vivo pharmacokinetic profile.The co-evaporate of lornoxicam with Pluronic® F-68 showed significantly faster dissolution and superior flowability and was evaluated together with three directly compressible excipients (Cellactose® 80, StarLac® and Emcompress®) for mini-tablet formulation. The formulation with StarLac® provided the optimum results in terms of tensile strength, content uniformity and rapid drug release following a 3 month stability study and was

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Section: Resultsmentioning

confidence: 99%

Dissolution Enhancement and Formulation of Rapid-Release Lornoxicam Mini-Tablets

Tawfeek

Saleem

Roberts

2014

Journal of Pharmaceutical Sciences

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“…A total of three RCTs yielded three comparisons, in which the oxicams class of NSAIDs were administered preoperatively, were incorporated in the metaanalyses, studying 172 adult patients (85 received oxicams, 87 received placebo; Table 1; Table 2, notes 13,14) (Akca et al, 2004;Gramke et al, 2006;Mowafi et al, 2011). The meta-analysed oxicams were lornoxicam (1 study, medium dose; Mowafi et al, 2011), piroxicam (1 study, high dose; Gramke et al, 2006) and tenoxicam (1 study, medium dose; Akca et al, 2004).…”

Section: Oxicamsmentioning

confidence: 99%

“…The meta-analysed oxicams were lornoxicam (1 study, medium dose; Mowafi et al, 2011), piroxicam (1 study, high dose; Gramke et al, 2006) and tenoxicam (1 study, medium dose; Akca et al, 2004).…”

Section: Oxicamsmentioning

confidence: 99%

“…Juhlin-Dannfelt et al, 1995;Liukkonen et al, 2002;Reiter et al, 2003;Wilder-Smith et al, 2003;Pozos-Guillen et al, 2007), non-steroidal antiinflammatory drugs (NSAIDs) (e.g. Takada et al, 2009;Kesimci et al, 2011;Mowafi et al, 2011), neuromodulatory agents (e.g. Al-Mujadi et al, 2006;Agarwal et al, 2008;Grover et al, 2009;Kinney et al, 2012) and clonidine (e.g.…”

Section: Introductionmentioning

confidence: 99%

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Preoperative preemptive drug administration for acute postoperative pain: A systematic review and meta‐analysis

Nir

Nahman‐Averbuch

Moont

et al. 2016

European Journal of Pain

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Preoperative administration of pharmacological substances, such as nonsteroidal anti-inflammatory drugs or opioids, has been gaining acclaim as a preemptive measure to minimize postoperative pain. This systematic review and meta-analysis aimed at evaluating the effectiveness of this approach in adults undergoing surgical procedures. MEDLINE, EMBASE and the Cochrane Central Register were searched from inception through January 2015. Data from randomized placebo-controlled trials were screened, extracted and assessed for risk of bias according to The Cochrane Collaboration's Tool by two independent authors. The primary outcome measure was reduction in postoperative analgesic consumption during 24 h post surgery; effects were described as mean differences between the drug and placebo arms with corresponding 95% confidence intervals (CIs) and were pooled using random-effects models. Potential publication bias was tested using funnel plots and Egger's regression test for funnel plot asymmetry. Screened were 511 records, of which 39 were included in the final synthesis with data from 3172 patients. A significant reduction in postoperative analgesic consumption was observed using preoperative administration of nonsteroidal anti-inflammatory drugs (NSAIDs; 95% CI, À0.61 to À0.14; 31 comparisons), chiefly by the COX-2 inhibitors class (95% CI, À0.95 to À0.33; 13 comparisons). Significant reduction was also observed for gabapentin (95% CI, À1.60 to À0.38; 6 comparisons). No significant effects were observed using opioids, propionic acids or oxicam derivatives. What does this review add?: Current analyses endorse the effectiveness of COX-2 inhibitors and gabapentin in reducing acute postoperative pain when administered preemptively presurgery. Such corroboration is not found for opioids and other NSAID classes.

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“…Lornoxicam and diclofenac had shown similar efficacy in postoperative pain relief in various surgical procedures [16][17][18][19]. Lornoxicam is used as analgesic in post lumbar puncture, tooth extraction and postoperatively following gynecological and orthopedic surgery.…”

Section: Commentsmentioning

confidence: 99%

Efficacy and safety of lornoxicam vs ibuprofen in primary dysmenorrhea: a randomized, double-blind, double dummy, active-controlled, cross over study

Patel

Patel²,

Acharya

et al. 2015

European Journal of Obstetrics & Gynecology and Reproductiv

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Preoperative lornoxicam for pain prevention after tonsillectomy in adults

Cited by 14 publications

References 26 publications

Dissolution Enhancement and Formulation of Rapid-Release Lornoxicam Mini-Tablets

Dissolution Enhancement and Formulation of Rapid-Release Lornoxicam Mini-Tablets

Preoperative preemptive drug administration for acute postoperative pain: A systematic review and meta‐analysis

Efficacy and safety of lornoxicam vs ibuprofen in primary dysmenorrhea: a randomized, double-blind, double dummy, active-controlled, cross over study

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