Pathology of the Hemostatic System

Литвицкий, Петр Францевич

doi:10.15690/vsp.v13i2.974

Cited by 2 publications

(1 citation statement)

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“…Additionally, the condition of the blood coagulation system is considered essential for development of disseminated intravascular coagulation (DIC). DIC leads to development of multiple organ failure syndromes with a mortality rate higher than 50 % [6][7][8][9].…”

Section: T He Liver Plays a Fundamental Role In Direct And Indirect Rmentioning

confidence: 99%

Morphofunctional changes in the liver and the state of the rat blood coagulation system in development of reperfusion syndrome

Arkadevich¹,

Vasilievna²,

Ivanovna³

et al. 2019

Medical news of the North Caucasus

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1 медицинская академия им. С. И. Георгиевского Крымского федерального университета им. В. И. Вернадского, Симферополь, Российская Федерация 2 Институт медико-биологических проблем РАН, москва, Российская Федерация Disseminated intravascular coagulation leads to the development of multiple organ failure syndromes with a mortality rate higher than 50 %. We examined the pathogenetic mechanisms of formation of systemic reperfusion syndrome in a rat model of reperfusion syndrome for 6, 12, and 24 hours. A total of 60 white Wistar rats, with a weight of 180-200 g, were studied. We found that morphological changes in the liver were manifested by formation of triggers for hepatocyte damage, including activation of apoptosis and initiation of pro-inflammatory damage pathways. These changes did not lead to severe alterations in functional activity of the liver. Disturbances in the blood coagulation system that developed with reperfusion syndrome with a potential threat of developing DIC were associated with increased consumption of coagulation factors. These disturbances in the blood coagulation system were also associated with inhibition of synthetic function of the liver to a lesser extent.

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Section: T He Liver Plays a Fundamental Role In Direct And Indirect Rmentioning

confidence: 99%

Morphofunctional changes in the liver and the state of the rat blood coagulation system in development of reperfusion syndrome

Arkadevich¹,

Vasilievna²,

Ivanovna³

et al. 2019

Medical news of the North Caucasus

View full text Add to dashboard Cite

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Significance of integral hematological indexes for predicting postoperative wound healing in the experiment

Супильников¹,

Shabalin²

2018

ZHurnal «Patologicheskaia Fiziologiia I Eksperimental`naia Terapiia»

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Цель исследования - оценка возможности использования интегральных гематологических индексов для выбора оптимальной модели ушивания послеоперационных ран в эксперименте. Методика. Исследование проводили на 297 белых беспородных крысах-самцах массой 190-210 г, которые были разделены на 3 группы, по 99 крыс в каждой. Одна группа являлась контрольной, у второй группы крыс был смоделирован раневой процесс с натяжением брюшной стенки; у третьей группы животных - модель раневого процесса с применением трансплантата нанокомпозитного материала. Определяли следующие интегральные гематологические индексы: индекс Кребса; коэффициент Бредекка; лейкоцитарный индекс; индекс соотношения нейтрофилов и моноцитов; индекс соотношения лимфоцитов и моноцитов; индекс соотношения лимфоцитов и эозинофилов; коэффициент отношения альбуминов к глобулинам; оксипролиновый коэффициент. Результаты. Установлены статистически значимые колебания показателей интегральных гематологических индексов в динамике заживления послеоперационной раны у крыс. Заключение. На основе полученных результатов был сделан вывод, что особенности динамики интегральных гематологических индексов, выявленные на различных моделях раневого процесса, отражают неспецифические и специфические защитные реакции организма в целом, позволяют делать прогноз дальнейшего течения и исхода раневого процесса, а также обеспечивают возможность выбора оптимальной модели ушивания послеоперационной раны. The article presents results of predicting the wound healing process using integral hematological indexes. The aim of the study was to describe the dynamics of integral hematological indexes of wound healing process in rats to predict its outcome. The study included 297 white mongrel male rats weighing 190-210 g, which were divided into three groups, 99 rats in each. One group was a control group; in the second group, a wound healing process with abdominal wall tension was modeled; in the third group, a wound healing process with a graft was modeled. The following integrated hematological indexes were determined: Krebs index; Bredeck index; leukocyte index; neutrophil/monocyte ratio; lymphocyte/monocyte ratio; lymphocyte/eosinophil ratio; albumin/globulin ratio; and oxyproline coefficient. The study showed that changes in values of integral hematological indexes were mostly statistically and clinically significant. We concluded that changes in integral hematological indexes in different models of wound healing reflect nonspecific and specific protective responses of the body as a whole and allow to predict further course and outcome of the wound healing process.

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Pathology of the Hemostatic System

Cited by 2 publications

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Morphofunctional changes in the liver and the state of the rat blood coagulation system in development of reperfusion syndrome

Morphofunctional changes in the liver and the state of the rat blood coagulation system in development of reperfusion syndrome

Significance of integral hematological indexes for predicting postoperative wound healing in the experiment

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